Nav: Home

Monoclonal antibody given to preterm babies may reduce wheeze later

February 03, 2017

Feb. 3, 2017 -- Preterm babies given the monoclonal antibody palivizumab to prevent respiratory syncytial virus (RSV) also appear less likely to develop recurrent wheeze, at least until the age of six, according to new research published online, ahead of print in the American Thoracic Society's American Journal of Respiratory and Critical Medicine.

In "Palivizumab Prophylaxis in Preterm Infants and Subsequent Recurrent Wheezing: 6 Year Follow-up Study," researchers report on multicenter case-control study of 444 Japanese infants born at 33-35 weeks gestation. The primary goal of the study was to determine if palivizumab prophylaxis would prevent the onset of atopic asthma. The drug did not, but it did significantly reduce physician-diagnosed recurrent wheezing up to six years of age.

"Our findings suggests two independent phenotypes of recurrent wheezing in young children: one that is dependent and one that is independent of RSV lower respiratory infection," said lead study author Hiroyuki Mochizuki, MD, PhD, professor and chairman of pediatrics at Tokai University in Japan.

The researchers found that infants who received at least three doses of palivizumab according to standard medical practice had about half the incidence of physician-diagnosed wheeze by age 6, compared to those who did not receive the drug (15.3 percent vs. 31.6 percent).

A strength of the study was that it was long-term prospective study in 52 centers with a high follow-up rate. The latter was achieved using an innovative method involving QR codes on mobile phones for photographing physician documentation of wheezing during outpatient and inpatient visits.

Study limitations include potential bias due to nonrandomized design. The authors noted that there were only minimal differences in family history of asthma, birth weight and gestational age among those who were treated and those who were not. Children in the untreated group, however, were more likely to live in a home with a smoker and have a family member with a history of allergy -- factors that would increase wheezing.

"These results suggest that atopic asthma in children up to age six is probably not due to RSV, but a significant proportion of recurrent wheeze is," Dr. Mochizuki said.

"Long-term observation of these subjects is planned to consider the impact of RSV infection on lung function in later life."
-end-
Share via Twitter

"#Preterm babies may develop less wheeze later in life if given monoclonal antibody palivizumab at birth."

Follow Us


ATS - @atscommunity
AJRCCM - @ATSBlueEditor

About the American Journal of Respiratory and Critical Care Medicine (AJRCCM):

The AJRCCM is a peer-reviewed journal published by the American Thoracic Society. The Journal takes pride in publishing the most innovative science and the highest quality reviews, practice guidelines and statements in pulmonary, critical care and sleep medicine. With an impact factor of 12.996, it is the highest ranked journal in pulmonology. Editor: Jadwiga Wedzicha, MD, professor of respiratory medicine at the National Heart and Lung Institute (Royal Brompton Campus), Imperial College London, UK.

About the American Thoracic Society:

Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy. The ATS publishes three journals, the American Journal of Respiratory and Critical Care Medicine, the American Journal of Respiratory Cell and Molecular Biology and the Annals of the American Thoracic Society.

The ATS will hold its 2017 International Conference, May 19-24, in Washington, DC, where world-renowned experts will share the latest scientific research and clinical advances in pulmonary, critical care and sleep medicine.

American Thoracic Society

Related Asthma Articles:

Physics vs. asthma
A research team from the MIPT Center for Molecular Mechanisms of Aging and Age-Related Diseases has collaborated with colleagues from the U.S., Canada, France, and Germany to determine the spatial structure of the CysLT1 receptor.
New knowledge on the development of asthma
Researchers at Karolinska Institutet in Sweden have studied which genes are expressed in overactive immune cells in mice with asthma-like inflammation of the airways.
Eating fish may help prevent asthma
A scientist from James Cook University in Australia says an innovative study has revealed new evidence that eating fish can help prevent asthma.
Academic performance of urban children with asthma worse than peers without asthma
A new study published in Annals of Allergy, Asthma and Immunology shows urban children with poorly controlled asthma, particularly those who are ethnic minorities, also suffer academically.
Asthma Controller Step Down Yardstick -- treatment guidance for when asthma improves
The focus for asthma treatment is often stepping up treatment, but clinicians need to know how to step down therapy when symptoms improve.
More Asthma News and Asthma Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...