Nav: Home

Breaking up amino acids with radiation

February 05, 2020

Small organic molecules, including the amino acids that form the 'building blocks' of proteins in living cells, fragment to form ions under the impact of high-energy radiation such as electron beams. A new study published in EPJ D has now shown what happens when electrons collide with one amino acid, glutamine. The extent of the damage and the nature of the ions formed are both affected by the energy of the colliding electrons. This work arises from a collaboration between experimental physicists led by Alexander Snegursky at the Institute of Electron Physics, Uzhgorod, Ukraine and theoreticians led by Jelena Tamuliene at Vilnius University, Vilnius, Lithuania.

The damaging effect of very high-energy radiation on human tissue is well-known from disasters such as the nuclear accidents at Chernobyl and Fukushima. However, the long-term effects experienced by survivors of such disasters, including an increased risk of cancer, are partly caused by the impact of rather lower-energy radiation. The groups chose to study the effect of electron impact on amino acids because they are less widely studied in this context than DNA.

Snegursky and his colleagues used mass spectrometry to measure the mass-to-charge ratio and thus determine the nature of chemical fragments produced when one biologically important amino acid, glutamine, was bombarded with uniform electron beams with different radiation doses. Meanwhile, the theoretical team modelled the electronic and geometric structures of glutamine and its fragments using quantum mechanics. The observed fragmentation patterns differed according to the radiation dose that the molecules received, and the experimental results were largely borne out by the simulations. The study authors believe that this basic research will have implications for understanding the effect of ionising radiation on human cells, improving the selectivity of radiotherapy beams for cancer cells, and even, perhaps, understanding the origin of life.
-end-
Reference

J. Tamuliene, L. Romanova, V. Vukstich and A.Snegursky (2020) High-energy ionizing radiation influence on the fragmentation of glutamine, European Physical Journal D 74:13, DOI: 10.1140/epjd/e2019-100523-7

Springer

Related Cancer Articles:

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.
Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.
Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.
Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.
More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.
New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.
American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.
Oncotarget: Cancer pioneer employs physics to approach cancer in last research article
In the cover article of Tuesday's issue of Oncotarget, James Frost, MD, PhD, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer.
Health indicators for newborns of breast cancer survivors may vary by cancer type
In a study published in the International Journal of Cancer, researchers from the UNC Lineberger Comprehensive Cancer Center analyzed health indicators for children born to young breast cancer survivors in North Carolina.
Few women with history of breast cancer and ovarian cancer take a recommended genetic test
More than 80 percent of women living with a history of breast or ovarian cancer at high-risk of having a gene mutation have never taken the test that can detect it.
More Cancer News and Cancer Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Making Amends
What makes a true apology? What does it mean to make amends for past mistakes? This hour, TED speakers explore how repairing the wrongs of the past is the first step toward healing for the future. Guests include historian and preservationist Brent Leggs, law professor Martha Minow, librarian Dawn Wacek, and playwright V (formerly Eve Ensler).
Now Playing: Science for the People

#565 The Great Wide Indoors
We're all spending a bit more time indoors this summer than we probably figured. But did you ever stop to think about why the places we live and work as designed the way they are? And how they could be designed better? We're talking with Emily Anthes about her new book "The Great Indoors: The Surprising Science of how Buildings Shape our Behavior, Health and Happiness".
Now Playing: Radiolab

The Third. A TED Talk.
Jad gives a TED talk about his life as a journalist and how Radiolab has evolved over the years. Here's how TED described it:How do you end a story? Host of Radiolab Jad Abumrad tells how his search for an answer led him home to the mountains of Tennessee, where he met an unexpected teacher: Dolly Parton.Jad Nicholas Abumrad is a Lebanese-American radio host, composer and producer. He is the founder of the syndicated public radio program Radiolab, which is broadcast on over 600 radio stations nationwide and is downloaded more than 120 million times a year as a podcast. He also created More Perfect, a podcast that tells the stories behind the Supreme Court's most famous decisions. And most recently, Dolly Parton's America, a nine-episode podcast exploring the life and times of the iconic country music star. Abumrad has received three Peabody Awards and was named a MacArthur Fellow in 2011.