Nav: Home

Voluntary control of brainwaves in deep brain of patients with Parkinson's disease

February 06, 2019

Parkinson's disease is associated with abnormal beta wave activity in the subthalamic nucleus (STN), but a direct connection between this activity and movement difficulties has not yet been established.

A study group at Osaka University developed a neurofeedback system (Figure 1) which enables patients with Parkinson's disease to voluntarily control beta wave activity in their deep brain (STN, Figure 2) associated with symptoms of the disorder. The group demonstrated that the patients can control these beta waves voluntary; however, it remains to be determined whether such a system can provide symptom relief. The group's research results were published in eNeuro.

"In a study of eight patients undergoing a routine replacement of a pulse generator used for deep brain stimulation, we developed a method that could help scientists better understand the relationship between brain activity and disease symptoms," says senior author Haruhiko Kishima.

In this study, the patients were trained to increase the size of a black circle that changes according to the participants' real-time beta wave activity. For half of the participants, the size of the black circle was positively correlated with beta wave intensity, and for other half of the participants, the circle was negatively correlated with beta wave intensity. After the 10 minutes of training, the study demonstrated that the patients' beta waves significantly increased or decreased depending on the circle condition. Using the real-time feedback system, the patients can voluntarily control their beta waves.

Corresponding author Takufumi Yanagisawa says, "Although we did not observe an improvement in patients' symptoms, our study represents a new approach toward managing disease-related brain activity that could lead to the development of new treatments."
-end-
The article, "Real-Time Neurofeedback to Modulate β-Band Power in the Subthalamic Nucleus in Parkinson's Disease Patients" was published in eNeuro at DOI: https://doi.org/10.1523/ENEURO.0246-18.2018.

About Osaka University

Osaka University was founded in 1931 as one of the seven imperial universities of Japan and now has expanded to one of Japan's leading comprehensive universities. The University has now embarked on open research revolution from a position as Japan's most innovative university and among the most innovative institutions in the world according to Reuters 2015 Top 100 Innovative Universities and the Nature Index Innovation 2017. The university's ability to innovate from the stage of fundamental research through the creation of useful technology with economic impact stems from its broad disciplinary spectrum.

Website: https://resou.osaka-u.ac.jp/en/top

Osaka University

Related Brain Activity Articles:

More brain activity is not always better when it comes to memory and attention
Potential new ways of understanding the cause of cognitive impairments, such as problems with memory and attention, in brain disorders including schizophrenia and Alzheimer's are under the spotlight in a new research review.
Researchers to predict cognitive dissonance according to brain activity
A new study by HSE researchers has uncovered a new brain mechanism that generates cognitive dissonance -- a mental discomfort experienced by a person who simultaneously holds two or more contradictory beliefs or values, or experiences difficulties in making decisions.
Brain activity can be used to predict reading success up to 2 years in advance
By measuring brainwaves, it is possible to predict what a child's reading level will be years in advance, according to research from Binghamton University, State University of New York.
There's a close association between magnetic systems and certain states of brain activity
Scientists from the University of Granada (UGR) have proven for the first time that there is a close relationship between several emerging phenomena in magnetic systems (greatly studied by condensed matter physicists) and certain states of brain activity.
Hormone can enhance brain activity associated with love and sex
The hormone kisspeptin can enhance activity in brain regions associated with sexual arousal and romantic love, according to new research.
Manipulating brain activity to boost confidence
Is it possible to directly boost one's own confidence by directly training the brain?
Brain activity may predict risk of falls in older people
Measuring the brain activity of healthy, older adults while they walk and talk at the same time may help predict their risk of falls later, according to a study published in the Dec.
Neuro chip records brain cell activity
In order to understand how the brain controls functions, such as simple reflexes or learning and memory, we must be able to record the activity of large networks and groups of neurons.
Too much activity in certain areas of the brain is bad for memory and attention
Researchers led by Dr Tobias Bast in the School of Psychology at The University of Nottingham have found that faulty inhibitory neurotransmission and abnormally increased activity in the hippocampus impairs our memory and attention.
Brain changes after menopause may lead to lack of physical activity
Researchers from the University of Missouri have found a connection between lack of ovarian hormones and changes in the brain's pleasure center, a hotspot in the brain that processes and reinforces messages related to reward, pleasure, activity and motivation for physical exercise.

Related Brain Activity Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...