Nav: Home

'Watch-and-Wait' strategy could safely replace surgery in more than 20% of rectal cancers

February 06, 2020

A team of doctors and scientists from the Champalimaud Clinical Centre in Lisbon, Portugal, and the Netherlands Cancer Institute in Amsterdam, has shown that patients with "low" rectal cancer (that is, very close to the anus) who show no sign of their tumors after a course of radio- and chemotherapy can safely choose to postpone invasive and complication-prone surgical procedures. These results have been published in the journal Annals of Surgery.

Agreeing instead to submit to a very close and strict surveillance of their condition during a period of at least two years, in a "Watch-and-Wait" strategy, they might even totally evade surgery without any negative impact on their health outcome, since the majority (around two-thirds) of these patients does not show any regrowth of the tumour after the first two years of "Watch-and-Wait".

What's most important, according to the scientists, is that of the remaining patients (around one-third), whose tumor does regrow within those first years and who undergo exactly the same surgical procedure as was initially planned for them, 97% show the same outcome as if the surgery had been performed immediately after radio-chemotherapy. In other words, no precious time will have been wasted by waiting and watching the patient.

Surgery still is, today, the frontline classical treatment protocol for rectal cancer cases - which represent about 30% of all colorectal cancers, or about six million new cases per year worldwide, according to 2018 estimates. But the fact is that, for certain particularly complicated locations of the tumor in the rectum, a previous course of radio-chemotherapy before surgery is required. Why? Because in these cases, it is necessary to reduce the size of the tumor that might already be invading the pelvic wall structures or even other organs.

This pre-operative treatment comes with its own side effects, increasing the probability of urinary and sexual dysfunction, worse bowel function or even deficient healing process. These could, in turn, have devastating post-operatory consequences, such as suture defects leading to peritonitis.

"For rectal tumors located less than seven centimeters from the anus, the patient is often submitted to radiochemotherapy during five weeks, having a subsequent recovery period of another eight to ten weeks before the surgical intervention", explains Nuno Figueiredo, head of the Champalimaud Surgical Centre and a colorectal surgeon at the Digestive Cancer Unit of the Champalimaud Clinical Centre, who is one of the co-authors of the new study together with his colleagues Marit Van der Sande and Geerard Beets, from the Netherlands Cancer Institute.

Moreover, in more than half of these low rectal cancer cases - which represent 30% to 40% of all rectal cancers, that is, around two million new cases per year worldwide, according to the same 2018 estimates -, the surgery may require removal of the rectum and surrounding tissue (abdominoperineal amputation), a condition that implies permanently redirecting the colon towards an incision made in the abdomen (colostomy). In these cases, the patient is fitted for life with a "bag" to collect stools directly through that artificial orifice.

For all the above reasons, surgery is potentially a very invasive procedure in low rectal cancer. But what if there was a non-invasive option to surgery that did not put eligible patients' lives at risk? The new study shows that this may actually be the case.

Unnecessary surgery?

The Watch-and-Wait strategy for rectal cancer was pioneered by surgeon Angelita Habr-Gama at the University of São Paulo, Brazil, some 20 years ago. Habr-Gama observed that, when patients with low rectal cancer were irradiated to prepare them for surgery due to the proximity of the tumor to the anus, histology results (biopsy) of the tissue harvested during the surgery often showed absolutely no trace of cancer cells. And she wondered whether the surgery, with its cohort of potential complications and life-long impact on patients' quality of life, had actually been necessary in those cases.

In the mid-2000's, surgeons in the Netherlands started proposing the alternative protocol to eligible patients. And in 2013, the Champalimaud Clinical Center and the University of Manchester in the UK were some of the first institutions in the world to follow suit. "Today, 53 centers around the world are using the same Watch-and-Wait protocol", says Figueiredo. "And in 2013, we created the International Watch-and-Wait Database to collect all the data generated by these centers."

The protocol consists in performing, eight to ten weeks after the chemoradiotherapy course, a series of diagnostic tests before deciding if surgery is warranted. "We use clinical and radiological observations to decide whether surgery is needed or not", says Figueiredo. "We perform three exams: digital rectal examination, endoscopy and magnetic resonance imaging." And if the patient's clinical response is "complete" - that is, if the tumor does not show up in any of these exams -, the patient is then told that they can enter the Watch-and-Wait (W&W) protocol. "One hundred percent of our patients at the Champalimaud Center choose this option", Figueiredo points out.

Before they make their decision, the patients are told that if, at any time during the following 24 months, any sign of tumor reappearance (or "regrowth") were to emerge, that would necessarily mean undergoing immediate surgery to remove the tumor in the exact way as initially programmed.

But if the cancer does not regrow during those first 24 months, the patient will then go on to be examined, at least every six months, for three additional years. After that, if it still doesn't reappear, the exams will continue at a rate of once a year.

Is it wise to wait?

Criticism of this protocol has focused, in particular, on the possibility of wasting precious time, during which the tumor could become, if not metastatic, possibly uncontrollable and impossible to remove surgically. It is this deferment of the surgery that the team has now shown to be safe in 97% of cases of tumor regrowth.

The new study involved 385 patients from both centers (83 from the Champalimaud) that were diagnosed between 2005 and 2018 and found to have a complete clinical response following chemoradiotherapy. Of those 385 patients, 89 (23 from Champalimaud) - or around 25% - had tumor regrowth during the first 24 months. And of the patients who experienced regrowth, "97% were rescued, which means operated on as initially programmed", says Figueiredo.

In other words, the W&W period did not compromise the outcome for those patients. The final result was the same they would have obtained if the surgery had been performed immediately.

There were also some patients included in W&W (3%) who were either too frail or too old to sustain a major abdominal operation - or who, experiencing a regrowth after the W&W period, refused to have surgery. These patients were then given the best possible palliative care.

Another line of criticism has to do with the possibility that waiting to see what happens could increase the risk of developing distant metastases, that is, of the initial tumor spreading to other parts of the body, in particular to the liver and lungs. Figueiredo points out that this study was not designed to answer this question.

However, what these researchers have effectively observed is that, compared to historical rectal series in the literature, for which 25% of the patients with rectal cancer go on to develop metastases, this only happened to 8.2% of the patients submitted to the W&W protocol. According to Figueiredo, this could simply reflect the fact that eligible patients for the alternative protocol have a much better prognosis than the general population of rectal cancer patients - and start out with a reduced risk of metastases.

Two next steps, he adds, are already ongoing, namely at the Champalimaud. One is to intensify radiation oncology protocols in order to increase the number of rectal cancer patients who reach a clinical complete response and become eligible for W&W - that is, to contemplate radio and chemotherapy as a standard standalone treatment for these tumours and not just a precursory step for surgery. The other is to improve the diagnostic accuracy of MRI and endoscopy exams in order to reduce the number of "false negatives" - that is, the number of apparently complete responses in which the tumor is actually still there after chemoradiotherapy but fails to be detected.
-end-


Champalimaud Centre for the Unknown

Related Cancer Articles:

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.
Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.
Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.
Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.
More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.
New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.
American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.
Oncotarget: Cancer pioneer employs physics to approach cancer in last research article
In the cover article of Tuesday's issue of Oncotarget, James Frost, MD, PhD, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer.
Health indicators for newborns of breast cancer survivors may vary by cancer type
In a study published in the International Journal of Cancer, researchers from the UNC Lineberger Comprehensive Cancer Center analyzed health indicators for children born to young breast cancer survivors in North Carolina.
Few women with history of breast cancer and ovarian cancer take a recommended genetic test
More than 80 percent of women living with a history of breast or ovarian cancer at high-risk of having a gene mutation have never taken the test that can detect it.
More Cancer News and Cancer Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.