Encouraging results reported for new breast cancer therapy

February 07, 2000

ROCHESTER, MINN. -- Mayo Clinic researchers report "encouraging" results with a new treatment for women with metastatic breast cancer. The researchers tested a combination of two drugs -- paclitaxel and carboplatin -- on 53 women. They reported a response rate (that is, evidence of tumor shrinkage) in 62 percent of the women and a projected one-year survival rate of 72 percent -- after follow-up ranging from 12 to 21 months.

Edith Perez, M.D., an oncologist at Mayo Clinic in Jacksonville, Fla., who led the multi-center study, said this is one of the highest response rates of any treatment for advanced breast cancer ever tested at Mayo Clinic.

She said this drug combination has been widely used in the treatment of ovarian and lung cancer but never before tried in breast cancer in the United States. "It's too early to know the long-term success of this treatment," she says. "But these early results are encouraging enough to serve as the basis for a number of new initiatives with this drug combination, both at Mayo Clinic and elsewhere."

One of the advantages of the new treatment, according to Dr. Perez, is that it is compatible with prior treatment with anthracycline, a drug commonly given to many women in the past for recurrent breast cancer. "This new combination is an additional therapy that adds additional benefits for these women," she says. The report appeared in a recent issue of the journal Cancer.

About 185,000 women are diagnosed with breast cancer every year. About ten percent have metastatic disease at the time of diagnosis, and about 40-50 percent of the others eventually develop metastatic disease, according to Dr. Perez.

Mayo Clinic

Related Breast Cancer Articles from Brightsurf:

Oncotarget: IGF2 expression in breast cancer tumors and in breast cancer cells
The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

Breast cancer: AI predicts which pre-malignant breast lesions will progress to advanced cancer
New research at Case Western Reserve University in Cleveland, Ohio, could help better determine which patients diagnosed with the pre-malignant breast cancer commonly as stage 0 are likely to progress to invasive breast cancer and therefore might benefit from additional therapy over and above surgery alone.

Partial breast irradiation effective treatment option for low-risk breast cancer
Partial breast irradiation produces similar long-term survival rates and risk for recurrence compared with whole breast irradiation for many women with low-risk, early stage breast cancer, according to new clinical data from a national clinical trial involving researchers from The Ohio State University Comprehensive Cancer Center - Arthur G.

Breast screening linked to 60 per cent lower risk of breast cancer death in first 10 years
Women who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women.

More clues revealed in link between normal breast changes and invasive breast cancer
A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

Breast tissue tumor suppressor PTEN: A potential Achilles heel for breast cancer cells
A highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report in Nature Communications that they have identified a novel pathway for connective tissue PTEN in breast cancer cell response to radiotherapy.

Computers equal radiologists in assessing breast density and associated breast cancer risk
Automated breast-density evaluation was just as accurate in predicting women's risk of breast cancer, found and not found by mammography, as subjective evaluation done by radiologists, in a study led by researchers at UC San Francisco and Mayo Clinic.

Blood test can effectively rule out breast cancer, regardless of breast density
A new study published in PLOS ONE demonstrates that Videssa® Breast, a multi-protein biomarker blood test for breast cancer, is unaffected by breast density and can reliably rule out breast cancer in women with both dense and non-dense breast tissue.

Study shows influence of surgeons on likelihood of removal of healthy breast after breast cancer dia
Attending surgeons can have a strong influence on whether a patient undergoes contralateral prophylactic mastectomy after a diagnosis of breast cancer, according to a study published by JAMA Surgery.

Young breast cancer patients undergoing breast conserving surgery see improved prognosis
A new analysis indicates that breast cancer prognoses have improved over time in young women treated with breast conserving surgery.

Read More: Breast Cancer News and Breast Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.