Nav: Home

High-risk sexually transmitted HPV virus associated with increased CVD risk

February 07, 2019

DALLAS, February 7, 2019 - Infection with high-risk strains of the human papillomavirus (HPV), which have been linked to cancer, might increase the risk of heart and blood vessel or cardiovascular disease, especially among women with obesity or other cardiovascular risk factors, according to new research in Circulation Research, an American Heart Association journal.

While cardiovascular disease has known risk factors -- such as cigarette smoking; high cholesterol, high blood pressure, physical inactivity, poor diet, obesity and diabetes -- to prevent cardiovascular disease, it is important to uncover other potential contributors.

One potential contributor is the most common sexually transmitted disease worldwide - the human papillomavirus or HPV. Certain strains of HPV are considered high risk because they can increase the risk of certain kinds of cancer, especially cervical, but also vaginal, vulvar, penile as well as mouth and throat. A Pap test can detect abnormal cells in the cervix, but HPV infection often has no symptoms until cancerous cells develop. Previous research among U.S. women linked high-risk HPV infection to self-reported diagnoses of past heart attack and stroke.

In this study, investigators looked at the relationship between high-risk HPV and cardiovascular disease diagnosed during the course of the study. After adjusting for other factors -- such as body mass index or BMI, a weight-to-height ratio, smoking, alcohol use, exercise, education level and family history of cardiovascular disease -- women with high-risk HPV were 22 percent more likely than uninfected women to develop cardiovascular disease.

The likelihood of cardiovascular disease rose even more when high-risk HPV occurred in conjunction with obesity or metabolic syndrome. Comparing high-risk positive to high-risk HPV negative women, women with obesity were nearly two-thirds more likely to develop cardiovascular disease, and those with metabolic syndrome and high-risk HPV were nearly twice as likely to develop cardiovascular disease.

Factors associated with a greater likelihood of high-risk HPV included current smoking and alcohol consumption. Interestingly, women who reported being physically active also were more likely to have high-risk HPV. In contrast, higher education, defined as a college degree or more, was associated with a decreased likelihood of having high-risk HPV.

"A better understanding of high-risk HPV as a risk factor for cardiovascular disease and possible combined effects of high-risk HPV, obesity and metabolic syndrome in increasing cardiovascular disease risk may help improve preventive strategies and patient outcomes," said Seungho Ryu, M.D., Ph.D., senior coauthor of the study and professor at Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, in Seoul, South Korea. "Further studies are required to identify specific high-risk HPV genotypes that may contribute to cardiovascular disease and to examine whether vaccine strategies to reduce high-risk HPV infection for cancer prevention may also help reduce cardiovascular disease."

From 2011 to 2016, 63,411 Korean women aged 30 or older without cardiovascular disease joined the study. Their average age was 40, and their average BMI was 22. Slightly more than 7 percent of the women had high-risk HPV infections.

All participants received a standard Pap test with DNA testing for 13 strains of high-risk HPV, as part of a comprehensive medical exam for the large Kangbuk Samsung Health Study in Seoul and Suwon, South Korea. Participants also provided informed consent to participate in the Insurance Review & Assessment Service once a year or once every two years for approximately four years. The Insurance Review & Assessment Service is a large database of healthcare costs, including those related to cardiovascular disease.

Several limitations could have affected the study's results, including the possibility that HPV status might have changed during the course of the study, since infections sometimes go away on their own. Additionally, the study could not determine the length of HPV infections, and information about high-risk HPV was lacking for more than one-third of participants.
-end-
Co-authors are Eun-Jeong Joo, M.D., Ph.D.; Yoosoo Chang, M.D., Ph.D..; Min-Jung Kwon, M.D., Ph.D.; Ara Cho, B.S.; and Hae Suk Cheong, M.D. Author disclosures are on the manuscript.

The Basic Science Research Program, through the Ministry of Education's National Research Foundation of Korea, funded the study.

Additional Resources:

Available multimedia located on the right column of the release link: https://newsroom.heart.org/news/high-risk-sexually-transmitted-hpv-virus-associated-with-increased-cardiovascular-disease-risk?preview=91464358f46fbf04faef0b5cc54fed6d
After February 7, view the manuscript online.
Follow AHA/ASA news on Twitter @HeartNews

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at https://www.heart.org/en/about-us/aha-financial-information.

About the American Heart Association

The American Heart Association is a leading force for a world of longer, healthier lives. With nearly a century of lifesaving work, the Dallas-based association is dedicated to ensuring equitable health for all. We are a trustworthy source empowering people to improve their heart health, brain health and well-being. We collaborate with numerous organizations and millions of volunteers to fund innovative research, advocate for stronger public health policies, and share lifesaving resources and information. Connect with us on heart.org, Facebook, Twitter or by calling 1-800-AHA-USA1.

American Heart Association

Related Obesity Articles:

Changing the debate around obesity
The UK's National Health Service (NHS) needs to do more to address the ingrained stigma and discrimination faced by people with obesity, says a leading health psychologist.
Study links longer exposure to obesity and earlier development of obesity to increased risk of type 2 diabetes
Cumulative exposure to obesity could be at least as important as actually being obese in terms of risk of developing type 2 diabetes (T2D), concludes new research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).
How much do obesity and addictions overlap?
A large analysis of personality studies has found that people with obesity behave somewhat like people with addictions to alcohol or drugs.
Should obesity be recognized as a disease?
With obesity now affecting almost a third (29%) of the population in England, and expected to rise to 35% by 2030, should we now recognize it as a disease?
Is obesity associated with risk of pediatric MS?
A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.
Women with obesity prior to conception are more likely to have children with obesity
A systematic review and meta-analysis identified significantly increased odds of child obesity when mothers have obesity before conception, according to a study published June 11, 2019 in the open-access journal PLOS Medicine by Nicola Heslehurst of Newcastle University in the UK, and colleagues.
Obesity medicine association announces major updates to its adult obesity algorithm
The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity.
Systematic review shows risk of a child developing overweight or obesity is more than trebled by maternal obesity prior to pregnancy
New research presented at this year's European Congress on Obesity (ECO) in Glasgow, Scotland (April 28- May 1) reveals that the risk of a child becoming overweight or obese is more than trebled by maternal obesity prior to getting pregnant.
Eating later in the day may be associated with obesity
Eating later in the day may contribute to weight gain, according to a new study to be presented Saturday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.
How obesity affects vitamin D metabolism
A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.
More Obesity News and Obesity Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Teaching For Better Humans 2.0
More than test scores or good grades–what do kids need for the future? This hour, TED speakers explore how to help children grow into better humans, both during and after this time of crisis. Guests include educators Richard Culatta and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Dispatch 3: Shared Immunity
More than a million people have caught Covid-19, and tens of thousands have died. But thousands more have survived and recovered. A week or so ago (aka, what feels like ten years in corona time) producer Molly Webster learned that many of those survivors possess a kind of superpower: antibodies trained to fight the virus. Not only that, they might be able to pass this power on to the people who are sick with corona, and still in the fight. Today we have the story of an experimental treatment that's popping up all over the country: convalescent plasma transfusion, a century-old procedure that some say may become one of our best weapons against this devastating, new disease.   If you have recovered from Covid-19 and want to donate plasma, national and local donation registries are gearing up to collect blood.  To sign up with the American Red Cross, a national organization that works in local communities, head here.  To find out more about the The National COVID-19 Convalescent Plasma Project, which we spoke about in our episode, including information on clinical trials or plasma donation projects in your community, go here.  And if you are in the greater New York City area, and want to donate convalescent plasma, head over to the New York Blood Center to sign up. Or, register with specific NYC hospitals here.   If you are sick with Covid-19, and are interested in participating in a clinical trial, or are looking for a plasma donor match, check in with your local hospital, university, or blood center for more; you can also find more information on trials at The National COVID-19 Convalescent Plasma Project. And lastly, Tatiana Prowell's tweet that tipped us off is here. This episode was reported by Molly Webster and produced by Pat Walters. Special thanks to Drs. Evan Bloch and Tim Byun, as well as the Albert Einstein College of Medicine.  Support Radiolab today at Radiolab.org/donate.