This graph depicts group differences in network efficiency. Specifically, patients with psychosis showed significantly reduced global efficiency in the frontoparietal and subcortical networks, in comparison to healthy controls.
"The premature 'aging' or degeneration of cortical networks has been increasingly documented in association with schizophrenia. However, we have very little insight into the underlying mechanisms. Linking these imaging findings to mechanism is a critical step to understanding the progression of schizophrenia so that we may disrupt it," said John Krystal, MD, Editor of Biological Psychiatry.
The finding that the decline in network efficiency appeared to begin after illness onset is particularly important for the potential to disrupt this progression. "With advances in cognitive remediation and the positive impact of exercise on connectivity of these networks, our findings provide hope that young adults with recent onset psychosis will benefit from interventions bolstering connectivity within these networks, potentially slowing down or normalizing the rate of decline in efficiency and, therefore, cognitive function," said Dr. Sheffield.
The findings of the new study help researchers understand how brain networks change over the course of psychotic disorders, and suggest that targeting these networks could disrupt the accelerated rate of normal aging in people with early stages of psychosis.
Notes for editors The article is "Accelerated aging of functional brain networks supporting cognitive function in psychotic disorders," by Julia M. Sheffield, Baxter P. Rogers, Jennifer U. Blackford, Stephan Heckers, and Neil D. Woodward (https://doi.org/10.1016/j.biopsych.2018.12.016). It appears in Biological Psychiatry, published by Elsevier.
Copies of this paper are available to credentialed journalists upon request; please contact Rhiannon Bugno at Biol.Psych@sobp.org or +1 214 648 0880. Journalists wishing to interview the authors may contact Julia M. Sheffield, PhD, at firstname.lastname@example.org or +1 615 875 9434.
The authors' affiliations and disclosures of financial and conflicts of interests are available in the article.
John H. Krystal, MD, is Chairman of the Department of Psychiatry at the Yale University School of Medicine, Chief of Psychiatry at Yale-New Haven Hospital, and a research psychiatrist at the VA Connecticut Healthcare System. His disclosures of financial and conflicts of interests are available here.
AboutBiological Psychiatry Biological Psychiatry is the official journal of the Society of Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders.
The journal publishes novel results of original research which represent an important new lead or significant impact on the field, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Reviews and commentaries that focus on topics of current research and interest are also encouraged.
Biological Psychiatry is one of the most selective and highly cited journals in the field of psychiatric neuroscience. It is ranked 6th out of 142 Psychiatry titles and 9th out of 261 Neurosciences titles in the Journal Citations Reports® published by Clarivate Analytics. The 2017 Impact Factor score for Biological Psychiatry is 11.982. http://www.sobp.org/journal
About ElsevierElsevier is a global information analytics business that helps institutions and professionals advance healthcare, open science and improve performance for the benefit of humanity. Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support and professional education, including ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, more than 38,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX Group, a global provider of information and analytics for professionals and business customers across industries. http://www.elsevier.com
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