Minimally-invasive hydrogen therapy of cancer based on in-vivo electrochemistry

February 07, 2020

Up to now, cancer is still one of the major diseases that threaten the survival of mankind, and it is difficult to cure clinically. In addition to single or combined surgery, chemotherapy and radiotherapy, which are commonly used clinically, a number of promising therapeutic strategies have been recently put forward including immunotherapy and gene therapy, photothermal therapy (PTT), photodynamic therapy, and so on. However, these techniques usually rely on chemical and genetic drugs or exotic nanomaterials to actualize treatments, making them quite difficult or debatable for practical clinical applications in near future due to the uncertainties of potential biotoxicity and biohazards, and related genetic and ethical issues; and immunotherapy and gene therapy are complex and expensive. Therefore, the popularization of these techniques in clinical practice is restricted. Consequently, developing simple, green, efficient and cheap treatment method is an urgent need to combat cancer.

Hydrogen, owing to its small molecular size and physiological inertness, resistance to oxidation, and good gas diffusivity in-vivo, is considered as a kind of green and endogenous gas. It performs the eminent physiological/pathological regulation functions, which is widely used for the treatment many diseases, such as, Alzheimer's disease, arthritis, diabetes and especially cancer. As early as 1975, researchers have applied the antioxidation of H2 to treat skin squamous cell carcinoma, but it requires using diving medical equipment to provide high pressure H2 which is restricted for clinic tumor therapy applications, how to produce H2 non-invasively and sufficiently without using nanomaterials and how to realize H2 releasing on demand in vivo are two huge challenges facing for the H2 therapy of cancers.

Acupuncture is a traditional and unique minimally-invasive method to treat diseases in China. It is quite effective to treat systemic diseases, especially for arthritis, cervical spondylopathy, psoatic strain and so on. But applying it to the treatment of major diseases, such as cancers is still a great challenge.

In a new research article published in the Beijing-based National Science Review, scientists at the State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China, and at School of Public Health, Jilin University, Changchun, China present the latest advances a green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry. Co-authors Guo-Hua Qi, Bo Wang, Xiangfu Song, Haijuan Li and Yong-dong Jin report the hydrogen cancer therapy in vivo with electrochemical. They have summarized the development of hydrogen in the treatment of cancer and the key problems limiting its development of clinical application.

These scientists have developed a simple and precise cancer therapy approach based on selective electrochemical generation of H2 in tumor region, termed in-vivo H2 generation electrochemotherapy (H2-ECT) by innovative combined use of traditional Chinese acupuncture Fe needle (electrode) and in-vivo electrochemistry. The H2-ECT method enables large-scale tumor therapy by applying gas diffusion effect, avoiding the shortcoming of limited effective area for classic electrochemical reactions. Moreover, due to the puncture positioning and acidic tumor microenvironment (compared to normal tissue), the method provides ideal selectivity and targeting to precisely kill tumors with minimal damage to normal tissue, which is very promising for potential clinic applications. The effectiveness of the method has been demonstrated by successful and fast treatment of glioma and breast cancers in mice in this study. The cost of cancer therapy is very low and less than 1 $ for each treatment.

Scientifically, a green and conceptually new in-vivo H2 generation electrochemotherapy (H2-ECT) of tumor has been developed. Prof. Yongdong Jin said that in a broader perspective, the H2-ECT provides a reliable method for the treatment of cancer and solves the heavy economic burden of cancer therapy bring to the family by high cost, so that it is easily popularized in poor country.
-end-
This research was supported by the National Key Research and Development Program of China, the National Natural Science Foundation of China, and the Instrument Developing Project of the Chinese Academy of Sciences.

See the article:

Guohua Qi, Bo Wang, Xiangfu Song, Haijuan Li and Yongdong Jin

A green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry

Natl Sci Rev, doi: 10.1093/nsr/nwz199

https://doi.org/10.1093/nsr/nwz199

The National Science Review is the first comprehensive scholarly journal released in English in China that is aimed at linking the country's rapidly advancing community of scientists with the global frontiers of science and technology. The journal also aims to shine a worldwide spotlight on scientific research advances across China.

Science China Press

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.