Nav: Home

Stroke journal features women's studies on how gender influences stroke risk, treatment and outcomes

February 08, 2018

DALLAS, Feb. 8, 2018 -- Many aspects of strokes affect women and men differently, and four articles in the American Heart Association's journal Stroke highlight recent research and identify future research needs.

"Gender influences all aspects of stroke, from risk factors, treatments and outcomes," said Marc Fisher, M.D editor in chief of the Stroke journal and professor of neurology at Harvard Medical School in Boston, Massachusetts. "Highlighting these studies, all led by female researchers, in February, a month when the American Heart Association/American Stroke Association focuses on women's health with Go Red For Women, is important. For too long, gender influences were not adequately studied."

The studies include:

Stroke risk factors unique to women

Stroke is the third leading cause of death in women in the United States and is a leading cause of disability. Each year 55,000 more women than men have a stroke, a discrepancy largely driven by longer life expectancy in women.

This review highlights stroke risk factors specific to women, including fluctuations in naturally occurring hormone levels over women's lives; adverse effects of supplemental hormones used as contraception or to treat menopausal symptoms; and pregnancy and pregnancy-related complications. The authors suggest that future research is needed to determine whether stroke risk prediction models should include risk factors specific to women such as supplemental hormones and pregnancy.

* After Feb. 8, view the manuscript online.

Preeclampsia: Association with posterior reversible encephalopathy syndrome and stroke

Preeclampsia is a complication of pregnancy characterized by high blood pressure which can cause damage to the brain, kidneys and liver. Preeclampsia can advance to eclampsia, which is characterized by seizures. Both of these conditions are associated with an increased risk of maternal death, ischemic stroke and hemorrhagic stroke. Preeclampsia is a treatable and possibly preventable condition which complicates up to 5 percent of pregnancies. The treatment for preeclampsia/eclampsia includes anti-hypertensives and magnesium.

According to this review, the risk of future ischemic stroke is approximately 80 percent greater in women with a history of preeclampsia than in those without the condition. Women whose pregnancy is complicated by preeclampsia or eclampsia should be counseled on the signs and symptoms of stroke and monitored closely in the postpartum period.

* After Feb. 8, view the manuscript online.

A focused update of sex differences in patient reported outcome measures (PROMs) after stroke

This study is an updated review of sex differences in patient reported outcome measures less than 12 months after stroke, using data from studies published since 2007.

The review confirms that after stroke women suffer more activity limitations, worse health related quality of life and more post stroke depression than men, but do not have worse cognitive impairment or challenges in dealing with everyday life compared to men. The authors note that there is a pressing need for high-quality population-based studies of sex differences in patient reported outcome measures after stroke. Studies exploring potential modifiable contributors to these differences are needed so effective interventions to reduce sex disparities in outcomes can be designed.

* After Feb. 8, view the manuscript online.

Impact of Conventional Stroke Risk Factors on Stroke in Women: An Update

Due to increasing stroke risk with age and a longer life expectancy, women experience more strokes and more death from stroke over their lifetime and have worse functional outcomes following stroke. This study reviews current literature (2013 to present) on ischemic strokes, the most common type of stroke caused by narrowing or blockages in the arteries leading to the brain, and the degree to which conventional risk factors affect men and women differently.

It concludes that risk factors -- including diabetes, metabolic syndrome, atrial fibrillation and migraine -- carry greater ischemic stroke risk for women compared with men. Metabolic syndrome is a cluster of risk factors that significantly raises the risk of heart disease and stroke; atrial fibrillation is a heart rhythm disorder. The association between elevated cholesterol and stroke may be slightly higher among men, and the role of high blood pressure is complicated, with varying effects based on age/race/ethnicity and gender.

The authors also note that treatment disparities between men and women leading to suboptimal stroke prevention in women need to be addressed.

* After Feb. 8, view the manuscript online.

Editorial: Stroke in Women

In this edition of Stroke, the papers by McDermott, Demel, Madsen, Gall/Lisabeth and colleagues argue for further recognition of the factors causing stroke in women as well as for systematic intensification of treatments. Sex differences in stroke burden are most influenced by differences in cardiovascular risk factor burden; thus, the greatest gains in stroke prevention will come from increased screening and treatment of these primary risk factors in women early in life, especially in the obese, women in pregnancy, and those from high-risk ethnoracial groups.

* After Feb. 8, view the manuscript online.

Co-authors, funding sources and author disclosures are on the manuscripts.
-end-
Additional Resources:

Follow AHA/ASA news on Twitter @HeartNews

For stroke science, follow the Stroke journal at @StrokeAHA_ASA

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at http://www.heart.org/corporatefunding.

About the American Heart Association

The American Heart Association is devoted to saving people from heart disease and stroke - the two leading causes of death in the world. We team with millions of volunteers to fund innovative research, fight for stronger public health policies, and provide lifesaving tools and information to prevent and treat these diseases. The Dallas-based association is the nation's oldest and largest voluntary organization dedicated to fighting heart disease and stroke. To learn more or to get involved, call 1-800-AHA-USA1, visit heart.org or call any of our offices around the country. Follow us on Facebook and Twitter.

About the American Stroke Association

The American Stroke Association is devoted to saving people from stroke -- the No. 2 cause of death in the world and a leading cause of serious disability. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat stroke. The Dallas-based association officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit StrokeAssociation.org. Follow us on Facebook and Twitter.

American Heart Association

Related Stroke Articles:

More stroke awareness, better eating habits may help reduce stroke risk for young adult African-Americans
Young African-Americans are experiencing higher rates of stroke because of health conditions such as high blood pressure, diabetes and obesity, yet their perception of their stroke risk is low.
How to help patients recover after a stroke
The existing approach to brain stimulation for rehabilitation after a stroke does not take into account the diversity of lesions and the individual characteristics of patients' brains.
Kids with headache after stroke might be at risk for another stroke
A new study has found a high incidence of headaches in pediatric stroke survivors and identified a possible association between post-stroke headache and stroke recurrence.
High stroke impact in low- and middle-income countries examined at 11th World Stroke Congress
Less wealthy countries struggle to meet greater need with far fewer resources.
Marijuana use might lead to higher risk of stroke, World Stroke Congress to be told
A five-year study of hospital statistics from the United States shows that the incidence of stroke has risen steadily among marijuana users even though the overall rate of stroke remained constant over the same period.
We need to talk about sexuality after stroke
Stroke survivors and their partners are not adequately supported to deal with changes to their relationships, self-identity, gender roles and intimacy following stroke, according to new research from the University of Sydney.
Standardized stroke protocol can ensure ELVO stroke patients are treated within 60 minutes
A new study shows that developing a standardized stroke protocol of having neurointerventional teams meet suspected emergent large vessel occlusion (ELVO) stroke patients upon their arrival at the hospital achieves a median door-to-recanalization time of less than 60 minutes.
Stroke affects more than just the physical
A new study looks at what problems affect people most after a stroke and it provides a broader picture than what some may usually expect to see.
Stroke journal features women's studies on how gender influences stroke risk, treatment and outcomes
Many aspects of strokes affect women and men differently, and four articles in the American Heart Association's journal Stroke highlight recent research and identify future research needs.
Too few with stroke of the eye are treated to reduce future stroke
Only one-third of 5,600 patients with retinal infarction, or stroke in the eye, underwent basic stroke work-up, and fewer than one in 10 were seen by a neurologist.
More Stroke News and Stroke Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Teaching For Better Humans 2.0
More than test scores or good grades–what do kids need for the future? This hour, TED speakers explore how to help children grow into better humans, both during and after this time of crisis. Guests include educators Richard Culatta and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Space
One of the most consistent questions we get at the show is from parents who want to know which episodes are kid-friendly and which aren't. So today, we're releasing a separate feed, Radiolab for Kids. To kick it off, we're rerunning an all-time favorite episode: Space. In the 60's, space exploration was an American obsession. This hour, we chart the path from romance to increasing cynicism. We begin with Ann Druyan, widow of Carl Sagan, with a story about the Voyager expedition, true love, and a golden record that travels through space. And astrophysicist Neil de Grasse Tyson explains the Coepernican Principle, and just how insignificant we are. Support Radiolab today at Radiolab.org/donate.