Findings of study comparing analgesics in acute post-trauma pain

February 08, 2021

DES PLAINES, IL -- The combination of a high?dose NSAID with paracetamol does not increase the analgesic effect compared to paracetamol alone. Researchers also found that paracetamol alone is superior to high?dose NSAID alone for posttraumatic extremity pain. These are the findings of a study titled Acetaminophen, or nonsteroidal anti-inflammatory drugs, or combination of both analgesics in acute post-trauma pain: a randomized controlled trial, to be published in the February 2021 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).

According to the study, taking into account its superior efficacy and tolerability, paracetamol appears to be the most suitable first-line therapy for managing mild to moderate post-traumatic extremity pain after discharge from the emergency department.

The lead author of the study is Mohamed Amine Msolli, MD, from the emergency department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

Commenting on the study is Andrew Chang, MD, MS, vice chair of research and academic affairs and professor of emergency medicine at Albany Medical Center in Albany, New York:

"This study of 1500 Tunisian adults, nearly 50% of whom had extremity fractures, provides evidence that paracetamol (acetaminophen) can be used as a first line analgesic, either alone or in combination with an NSAID, in the treatment of acute extremity injuries after emergency department (ED) discharge. Although this was not their primary hypothesis, the surprising efficacy of paracetamol over an NSAID, as shown by a 6.4% lower need for additional oral analgesics, may impact prescribing practices. For example, many ED patients who have a contraindication to NSAIDS but require analgesics upon ED discharge might be prescribed an opioid. Given the ongoing opioid epidemic, this study lends evidence to support the use of acetaminophen alone in such patients."
-end-
ABOUT ACADEMIC EMERGENCY MEDICINE

Academic Emergency Medicine, the monthly journal of Society for Academic Emergency Medicine, features the best in peer-reviewed, cutting-edge original research relevant to the practice and investigation of emergency care. The above study is published open access and can be downloaded by following the DOI link: 10.1111/acem.14169. Journalists wishing to interview the authors may contact Tami Craig at tcraig@saem.org.

ABOUT THE SOCIETY FOR ACADEMIC EMERGENCY MEDICINE

SAEM is a 501(c)(3) not-for-profit organization dedicated to the improvement of care of the acutely ill and injured patient by leading the advancement of academic emergency medicine through education and research, advocacy, and professional development. To learn more, visit saem.org.

Society for Academic Emergency Medicine

Related Acetaminophen Articles from Brightsurf:

A pain reliever that alters perceptions of risk
While acetaminophen is helping you deal with your headache, it may also be making you more willing to take risks, a new study suggests.

Research shows ibuprofen does not hinder bone fracture healing in children
Doctors have traditionally avoided prescribing nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen to patients with fractures.

Le Bonheur Children's Hospital trial: Intravenous indomethacin more effective for hsPDAs
Le Bonheur and the University of Tennessee Health Science Center neonatologists, led by Jennifer M.

A prescription for the pain of rejection: Acetaminophen and forgiveness
A study, published recently in the Annals of Behavioral Medicine may have found an antidote to heartbreak -- forgiveness combined with acetaminophen, the active ingredient in Tylenol.

UTHealth's Cynthia Ju awarded NIH grants for liver injury research
Tiny solutions are being sought for big liver problems by a scientist at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).

Study examines fetal exposure to acetaminophen, risk of childhood ADHD, ASD
Umbilical cord blood samples were used to examine an association between fetal exposure to acetaminophen and risk of childhood attention-deficit/hyperactivity disorder, autism spectrum disorder and other developmental disabilities in a group of nearly 1,000 mother-child pairs.

NIH-funded study suggests acetaminophen in pregnancy linked to higher risk of ADHD, autism
Exposure to acetaminophen in the womb may increase a child's risk for attention deficit/hyperactivity disorder and autism spectrum disorder, suggests a study funded by the National Institutes of Health and the Agency for Health Care Research and Quality.

OHIO study: Acetaminophen can reduce positive empathy for others
A new study by an Ohio University faculty member showed that acetaminophen limited positive empathy a person has for others while taking it.

Scientists find new therapy target for drug-induced liver failure
Acetaminophen -- a commonly used pain reliever and fever reducer -- is the leading cause of quickly developing, or acute, liver failure in the U.S.

Acetaminophen may increase stroke risk for those with diabetes
Surprisingly, we are only now coming to understand how acetaminophen works -- and recent research shows that we may need to develop a better understanding of the need for caution when using acetaminophen, especially when it comes to avoiding some of the risks associated with its use.

Read More: Acetaminophen News and Acetaminophen Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.