Findings of study comparing analgesics in acute post-trauma pain

February 08, 2021

DES PLAINES, IL -- The combination of a high?dose NSAID with paracetamol does not increase the analgesic effect compared to paracetamol alone. Researchers also found that paracetamol alone is superior to high?dose NSAID alone for posttraumatic extremity pain. These are the findings of a study titled Acetaminophen, or nonsteroidal anti-inflammatory drugs, or combination of both analgesics in acute post-trauma pain: a randomized controlled trial, to be published in the February 2021 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).

According to the study, taking into account its superior efficacy and tolerability, paracetamol appears to be the most suitable first-line therapy for managing mild to moderate post-traumatic extremity pain after discharge from the emergency department.

The lead author of the study is Mohamed Amine Msolli, MD, from the emergency department, Fattouma Bourguiba University Hospital, Monastir, Tunisia.

Commenting on the study is Andrew Chang, MD, MS, vice chair of research and academic affairs and professor of emergency medicine at Albany Medical Center in Albany, New York:

"This study of 1500 Tunisian adults, nearly 50% of whom had extremity fractures, provides evidence that paracetamol (acetaminophen) can be used as a first line analgesic, either alone or in combination with an NSAID, in the treatment of acute extremity injuries after emergency department (ED) discharge. Although this was not their primary hypothesis, the surprising efficacy of paracetamol over an NSAID, as shown by a 6.4% lower need for additional oral analgesics, may impact prescribing practices. For example, many ED patients who have a contraindication to NSAIDS but require analgesics upon ED discharge might be prescribed an opioid. Given the ongoing opioid epidemic, this study lends evidence to support the use of acetaminophen alone in such patients."

Academic Emergency Medicine, the monthly journal of Society for Academic Emergency Medicine, features the best in peer-reviewed, cutting-edge original research relevant to the practice and investigation of emergency care. The above study is published open access and can be downloaded by following the DOI link: 10.1111/acem.14169. Journalists wishing to interview the authors may contact Tami Craig at


SAEM is a 501(c)(3) not-for-profit organization dedicated to the improvement of care of the acutely ill and injured patient by leading the advancement of academic emergency medicine through education and research, advocacy, and professional development. To learn more, visit

Society for Academic Emergency Medicine

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