Early study points to potential therapeutic avenue for a pair of rare pediatric diseases

February 09, 2021

GRAND RAPIDS, Mich. (Feb. 9, 2021) -- Scientists have devised a new approach for detecting and potentially heading off the effects of two rare pediatric diseases before birth.

The study, performed in mouse models of the diseases and published today in Cell Reports, represents an important step toward much-needed early interventions for Beckwith-Wiedemann syndrome and Silver-Russell syndrome.

Both diseases result in growth-related symptoms in children and often lead to additional problems later in life, such as increased cancer risk from Beckwith-Wiedemann syndrome and increased metabolic disease risk from Silver-Russell syndrome.

"Both of these diseases have lifelong consequences," said Piroska Szabó, Ph.D., an associate professor at Van Andel Institute and the study's corresponding author. "Our findings provide a critical foundation for additional studies that we hope will translate into new, life-changing prenatal detection and treatment methods. Our goal is for children to be born healthy."

Fetuses with Beckwith-Wiedemann syndrome experience too much growth during development while fetuses with Silver-Russell experience too little growth. Likewise, about one-third of Beckwith-Wiedemann cases and two-thirds of Silver-Russell cases may arise from having either too much or too little of a protein called IGF2, which plays a critical role in fetal growth and development.

Using models of the diseases, Szabó and colleagues were able to detect and measure IGF2 in amniotic fluid and correlate variations in IGF2 levels with Beckwith-Wiedemann and Silver-Russell syndromes, opening up new opportunities for early detection.

The researchers also were able to correct IGF2 levels in a genetic experiment, essentially reversing the fetal growth problems associated with both disease models. They found that treatment before birth with an FDA-approved cancer medication that targets IGF2 signaling normalized fetal growth in the Beckwith-Wiedemann model.

More research and clinical studies are needed before it is known whether the findings hold true in humans, Szabó cautioned. She hopes to find a clinical collaborator with whom to partner for future studies.

"There's a big gap between an experiment in the lab and implementation in the clinic," Szabó said. "However, our results are a vital step toward finding ways to identify and treat these syndromes before birth."
-end-
Authors include Ji Liao, Ph.D., Tie-Bo Zeng, Ph.D., and Nicholas Pierce of VAI; and Diana A. Tran, Purnima Singh, M.S., Ph.D., MB, MSPH, and Jeffrey R. Mann, Ph.D., of City of Hope.

This work was supported by Van Andel Institute and the National Institute of General Medical Sciences of the National Institutes of Health under award no. R01GM064378 (Szabó). The content is solely the responsibility of the authors and does not necessarily represent the official views of the granting organization.

ABOUT VAN ANDEL INSTITUTE

Van Andel Institute (VAI) is committed to improving the health and enhancing the lives of current and future generations through cutting edge biomedical research and innovative educational offerings. Established in Grand Rapids, Michigan, in 1996 by the Van Andel family, VAI is now home to more than 400 scientists, educators and support staff, who work with a growing number of national and international collaborators to foster discovery. The Institute's scientists study the origins of cancer, Parkinson's and other diseases and translate their findings into breakthrough prevention and treatment strategies. Our educators develop inquiry-based approaches for K-12 education to help students and teachers prepare the next generation of problem-solvers, while our Graduate School offers a rigorous, research-intensive Ph.D. program in molecular and cellular biology. Learn more at vai.org.

Van Andel Research Institute

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