Children's National urologist receives NIH R01 grant

February 10, 2017

WASHINGTON - Children's National Health System Urologist Michael Hsieh, M.D., was awarded a National Institutes of Health (NIH) grant to optimize a set of parasite proteins that could alleviate pain in multiple types of bladder inflammation.

The $1 million R01 grant will fund a five-year study to exploit a parasite-derived protein, IPSE, as a candidate therapeutic. Dr. Hsieh hypothesizes that IPSE may have the ability to modulate host immune and non-immune responses to bladder injury. IPSE could be optimized for therapeutic potential, while minimizing toxicity, by generating forms that have the ability to modulate host responses via three distinct mechanisms: IL-4-binding, chemokine-binding and nuclear localization.

"Painful bladder syndromes affect up to 40 percent of patients and effective therapies do not exist for many of these patients," says Dr. Hsieh. "In the past, our research focused on understanding pathogens and their interaction with other agents. Now, we are turning the biology on its head and using them to eliminate pain."

Using what is already known about the sequence and structure of IPSE, Dr. Hsieh and his research team will use targeted and random methods to generate mutant forms of IPSE, and test their ability to alleviate bladder pain. The team will also screen these mutants for low toxicity in various tests. The long-term goal is to develop IPSE as a possible alternative to opioids for treating pain in general, which would greatly expand its therapeutic potential.

Dr. Hsieh joins a very small group of seven pediatric urologists in the country who received the R01, the oldest grant mechanism used by NIH. Dr. Hsieh and his team will collaborate with Theodore Jardetzky, professor of structural biology at Stanford University, and Franco Falcone, associate professor in allergy and infectious diseases, Faculty of Science at University of Nottingham in the U.K.

Children's National Health System

Related Biology Articles from Brightsurf:

Experimental Biology press materials available now
Though the Experimental Biology (EB) 2020 meeting was canceled in response to the COVID-19 outbreak, EB research abstracts are being published in the April 2020 issue of The FASEB Journal.

Structural biology: Special delivery
Bulky globular proteins require specialized transport systems for insertion into membranes.

Cell biology: All in a flash!
Scientists of Ludwig-Maximilians-Universitaet (LMU) in Munich have developed a tool to eliminate essential proteins from cells with a flash of light.

A biology boost
Assistance during the first years of a biology major leads to higher retention of first-generation students.

Cell biology: Compartments and complexity
Ludwig-Maximilians-Universitaet (LMU) in Munich biologists have taken a closer look at the subcellular distribution of proteins and metabolic intermediates in a model plant.

Cell biology: The complexity of division by two
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have identified a novel protein that plays a crucial role in the formation of the mitotic spindle, which is essential for correct segregation of a full set of chromosomes to each daughter cell during cell division.

Cell biology: Dynamics of microtubules
Filamentous polymers called microtubules play vital roles in chromosome segregation and molecular transport.

The biology of color
Scientists are on a threshold of a new era of color science with regard to animals, according to a comprehensive review of the field by a multidisciplinary team of researchers led by professor Tim Caro at UC Davis.

Kinky biology
How and why proteins fold is a problem that has implications for protein design and therapeutics.

A new tool to decipher evolutionary biology
A new bioinformatics tool to compare genome data has been developed by teams from the Max F.

Read More: Biology News and Biology Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to