A new strategy to destroy cancer cells using magnetic nanoparticles and fields

February 11, 2021

Scientists from Scientific and Educational Center «Smart Materials and Biomedical Applications» under the leadership of Kateryna Levada together with colleagues from Center for Immunology and Cellular Biotechnology of the Immanuel Kant Baltic Federal University conducted a joint interdisciplinary study on the development of a new method for treating leukemia using nanomaterials. The scientists analyzed how magnetic nanoparticles can be manipulated in in vitro conditions to achieve a selective antitumor effect. The method is based on the combined action of nanoparticles and permanent magnetic fields on human tumor cells.

Leukemia (lymphoblastic leukemia) is the most common type of blood cancer in children and adolescents. This cancer affects the bone marrow and leads to the degradation of the human immune system. It accounts for 75-80% of acute leukemias, which also affect adults. Current methods of treating leukemia are based on chemotherapy. But chemotherapy is expensive and toxic not only for cancer cells, but also for the entire body. To overcome these limitations, new approaches using nanomaterials are needed. In their work, the researchers used magnetic nanoparticles and constant magnetic fields.

For the study, the scientists used magnetic iron oxide nanoparticles, as they are a promising basis for the development of biomedical applications. Such materials are biocompatible and can be modified in the future, for example, with fluorescent labels (for microscopic methods), as well as covered with various shells. The development of targeted antitumor drugs requires studying the effect of the material used not only on cancers, but also on healthy cells of the body. The first cell line - mononuclear cells of human blood, served as a model of healthy cells. The second is human lymphoblastic leukemia cells, a cell line under the special name "Jurkat". Thus, the scientists simultaneously studied the effects of magnetic fields and nanoparticles on healthy and cancerous human cells. Permanent magnets, which were fixed in a stationary position in culture plates, were used as sources of the magnetic field. They supported the magnets to prevent any displacement during experiments. After placing all the necessary components, the plates with the cells were placed on top of the plates - this ensured a uniform distribution of magnetic fields on the surface of the plates containing the wells with the cells.

The results of the study showed that the combined effect of nanoparticles and magnetic fields after 24 h treatment affected the Jurkat cells - their viability was decreased. Iron oxides have been found to penetrate cancer cells and cause the release of reactive oxygen species, disrupting cellular processes. Scientists were particularly interested in the fact that healthy cells (human blood mononuclear cells) were not in any way suppressed by this "therapy".

"Thus, the use of nanoparticles based on iron oxides with optimized characteristics (shape, size, chemical composition) will allow in the future to achieve a therapeutic effect by generating reactive oxygen species in cancer cells. The difference in the susceptibility of healthy body cells and tumor cells to the effects of nanoparticles will provide a selective therapeutic effect and, therefore, minimize side effects," says Larisa Litvinova, MD, Director of Center for Immunology and Cellular Biotechnology IKBFU.

"The interdisciplinary approach in this study, namely, the joint work of scientists from various scientific fields, allowed us to demonstrate the interaction of these nanomaterials with cell cultures and, thus, to reveal the potential application significance of our developments. We also express our deep gratitude to our collaborators - Center for Immunology and Cellular Biotechnology IKBFU, under the leadership of Larisa Litvinova, for a joint interesting and productive scientific project," commented Kateryna Levada, PhD, Head of the Laboratory of Biomedical Applications of the Scientific and Educational Center "Smart Materials and Biomedical Applications".

Immanuel Kant Baltic Federal University

Related Cancer Cells Articles from Brightsurf:

Cancer researchers train white blood cells to attacks tumor cells
Scientists at the National Center for Tumor Diseases Dresden (NCT/UCC) and Dresden University Medicine, together with an international team of researchers, were able to demonstrate that certain white blood cells, so-called neutrophil granulocytes, can potentially - after completing a special training program -- be utilized for the treatment of tumors.

New way to target some rapidly dividing cancer cells, leaving healthy cells unharmed
Scientists at Johns Hopkins Medicine and the University of Oxford say they have found a new way to kill some multiplying human breast cancer cells by selectively attacking the core of their cell division machinery.

Breast cancer cells use message-carrying vesicles to send oncogenic stimuli to normal cells
According to a Wistar study, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells.

Breast cancer cells turn killer immune cells into allies
Researchers at Johns Hopkins University School of Medicine have discovered that breast cancer cells can alter the function of immune cells known as Natural killer (NK) cells so that instead of killing the cancer cells, they facilitate their spread to other parts of the body.

Breast cancer cells can reprogram immune cells to assist in metastasis
Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body.

Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells
CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia.

Drug that keeps surface receptors on cancer cells makes them more visible to immune cells
A drug that is already clinically available for the treatment of nausea and psychosis, called prochlorperazine (PCZ), inhibits the internalization of receptors on the surface of tumor cells, thereby increasing the ability of anticancer antibodies to bind to the receptors and mount more effective immune responses.

Engineered bone marrow cells slow growth of prostate and pancreatic cancer cells
In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response.

First phase i clinical trial of CRISPR-edited cells for cancer shows cells safe and durable
Following the first US test of CRISPR gene editing in patients with advanced cancer, researchers report these patients experienced no negative side effects and that the engineered T cells persisted in their bodies -- for months.

Zika virus' key into brain cells ID'd, leveraged to block infection and kill cancer cells
Two different UC San Diego research teams identified the same molecule -- αvβ5 integrin -- as Zika virus' key to brain cell entry.

Read More: Cancer Cells News and Cancer Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.