A new tool for improving uterine transplant surgery

February 12, 2018

Future Science Group (FSG) today announced the publication of an article in Future Science OA demonstrating the first use of multispectral imaging in gynecology, in a uterine transplant setting.

Uterine transplantation aims to remedy absolute uterine factor infertility, or the absence of a womb, allowing pregnancy. The first reported successful pregnancy following uterine transplantation was in 2014.

Currently, there is an absence of real-time, functional and molecular data during, pre- and post-surgery. This is particularly apparent in uterine transplants where there is a need to assess the level of ischemia and reperfusion injury during and post-transplantation, and prior to any potential pregnancy.

"We wanted to explore avenues that may potentially be better at evaluating tissue and organ perfusion than existing methods," commented Srdjan Saso (Imperial College London, UK). "Multi-spectral imaging (MSI), an example of biomedical photonics, proved effective at giving us a real-time, spatial picture of graft perfusion and therefore tissue viability."

Biomedical photonics is able to process data concerning hemoglobin concentration and oxygen saturation in a noninvasive manner in real time. The study compared two photonic applications using animal models: pulse oximetry and MSI. MSI was able to map oxygen saturation over the entire graft, demonstrating advantages over pulse oximetry and showing promise for use in humans.

"The ability to obtain such results using MSI will allow the surgical team to act appropriately during pelvic surgery and most importantly intra-operatively in order to rectify any issues," explained Saso. MSI therefore has the potential to become an effective tool in transplant surgery.

"[Our] next goal is to evaluate the effect of hypo-oxygenation on long-term organ function. We will evaluate uterine viability with various functional long-term variables to confirm the utility of MSI," he concluded.

The full research article is open access and available here: https://www.future-science.com/doi/10.4155/fsoa-2017-0129
-end-
About Future Science OA

Launched in March 2015, Future Science OA is a gold open access, biomedical journal from the Future Science Group. It publishes articles covering the latest research of application to human health, and utilizes a CC-BY license. Future Science OA embraces the importance of publishing all good-quality research with the potential to further the progress of medical science. Both negative and early-phase research is considered. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis.

About Future Science Group

Founded in 2001, Future Science Group (FSG) is a progressive publisher focused on breakthrough medical, biotechnological, and scientific research. FSG's portfolio includes two imprints, Future Science and Future Medicine. Both publish eBooks and journals. In addition to this core publishing business FSG develops specialist eCommunities. Key titles and sites include Bioanalysis Zone, Epigenomics, Nanomedicine and the award-winning Regenerative Medicine.

The aim of FSG is to service the advancement of clinical practice and drug research by enhancing the efficiency of communications among clinicians, researchers and decision-makers, and by providing innovative solutions to their information needs. This is achieved through a customer-centric approach, use of new technologies, products that deliver value-for-money and uncompromisingly high standards. http://www.futuresciencegroup.com

Future Science Group

Related Transplantation Articles from Brightsurf:

A revolutionary new treatment alternative to corneal transplantation
A new approach in ophthalmology that offers a revolutionary alternative to corneal transplantation has just been developed by researchers and clinicians in North America, Europe, and Oceania.

Fewer complications after organ transplantation
A large international study coordinated by University Hospital Regensburg and Charité - Universitätsmedizin Berlin has demonstrated the safety of new cell therapy approaches for use in kidney transplant recipients.

Elderly patients also benefit from kidney transplantation
So far, kidney transplantation has generally not been offered to elderly patients (>75 years) because of the perioperative risks.

New material will allow abandoning bone marrow transplantation
Scientists from the National University of Science and Technology 'MISIS' developed nanomaterial, which will be able to restore the internal structure of bones damaged due to osteoporosis and osteomyelitis.

Fewer medical tests -- timely listing for transplantation
Younger patients would benefit greatly from kidney transplantation. Their expected remaining lifetime may even be doubled by having a transplant.

Uterus transplantation -- ethically just as problematic as altruistic surrogacy
In 2014, the first child to have been gestated in a donated uterus was born.

Advancing transplantation: Hepatitis C-infected organs safe for transplantation when followed by antiviral treatment
Twenty patients at Penn Medicine have been cured of the hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease, according to a study published today in Annals of Internal Medicine.

Transplantation followed by antiviral therapy cured hepatitis C
Twenty patients who received kidneys transplanted from hepatitis C virus (HCV)-infected donors experienced HCV cure, good quality of life, and excellent renal function at one year.

The Journal of Heart and Lung Transplantation: 50 years of heart transplantation progress
This month marks the 50th anniversary of the world's first human heart transplant performed at Groote Schuur Hospital in Cape Town by South African surgeon, Christiaan Barnard.

Older donor lungs should be considered for transplantation
With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery.

Read More: Transplantation News and Transplantation Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.