Picture this: FSU professor's research could lead to vastly improved medical imaging

February 13, 2007

TALLAHASSEE, Fla. -- Magnetic resonance imaging, or MRI, has revolutionized health care, providing doctors with a highly accurate, non-invasive tool for diagnosing cancer, injuries and other maladies within the human body. Now, a Florida State University researcher has collaborated in a research project that could lead to ways of producing even sharper medical images.

Naresh Dalal, the Dirac Professor of Chemistry and Biochemistry at FSU, recently conducted experiments with other researchers from FSU, the University of Colorado and the National Institute of Standards and Technology that uncovered unique properties in a molecular magnet -- properties that could significantly increase the resolution of MRIs. Their paper, "Efficacy of the Single-Molecule Magnet Fe8 for Magnetic Resonance Imaging Contrast Agent Over a Broad Range of Concentration," was published in the current issue of Polyhedron, a rigorously peer-reviewed science journal.

"There are continual efforts to enhance the level of image clarity found in today's MRI devices," Dalal said. "MRIs utilize injectable dyes, but those in current use, while easy to manufacture, offer a relatively low contrast. Our experiments show that a class of materials known as single-molecule magnets might produce greater contrast in medical imaging, meaning MRIs would be much more accurate."

Working at FSU and the National High Magnetic Field Laboratory, Dalal and another FSU researcher, chemistry graduate teaching assistant Vasanth Ramachandran, were able to synthesize a substance known as Fe8 that is one of the strongest magnets known.

"Fe8 is a molecule made up of eight iron ions that form a tight molecular bond," Dalal said. "It has a powerful magnetic field, which is obviously important in generating a very clear image with an MRI device. What's more, Fe8 is non-toxic and water-soluble, making it safe for injection into the body."

Molecular magnets such as Fe8 hold great potential for other applications as well, he said.

"Computer memories and other high-tech storage devices utilize magnetic compounds," Dalal said. "Consider the compact disc. Using current technologies, the magnetic coating on a disc's surface is about 1 micron -- one-millionth of a meter -- in depth. But if a CD instead was coated with Fe8, the Fe8 film would be only about a nanometer -- one-billionth of a meter -- deep. This could increase our ability to store data in smaller and smaller spaces." It also could lead to significant breakthroughs in the area of quantum computing, which has the potential to create computers that are exponentially faster and more powerful than the ones in use today, he said.

Despite the promising results suggested by the team's research, Dalal admitted that there still are some hurdles to overcome before Fe8 becomes a viable MRI option.

"These compounds are not very stable," he said. "They break down in water within a few hours. We're now looking at ways to increase their stability so that they can be stored for long periods of time and transported easily."
Additional information about the researchers' findings is available at www.nist.gov/public_affairs/techbeat/tb2007_0201.htm#magnets.

In addition to Dalal and Ramachandran, another researcher on the project has FSU ties. Brant Cage of the National Institute of Standards and Technology is a former student of Dalal's who received his doctorate in chemistry at FSU in 2001.

Dalal's research is supported by an eight-year, $600,000 National Science Foundation grant. The grant is in its sixth year.

Florida State University

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