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New study compares bone-inducing properties of 3-D-printed mineralized scaffolds

February 13, 2017

New Rochelle, NY, February 13, 2017--A new study of bone formation from stem cells seeded on 3D-printed bioactive scaffolds combined with different mineral additives showed that some of the scaffold mineral composites induced bone-forming activity better than others. The properties and potential to use these bioactive scaffolds in bone regeneration applications are discussed in an article published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineering website until March 13, 2017.

Ethan Nyberg, Alexandra Rindone, Amir Dorafshar, and Warren Grayson, Johns Hopkins University School of Medicine and Johns Hopkins University, Baltimore, MD, examined the print quality of several different composite 3D-printed bone scaffolds. In the article entitled "Comparison of 3D-Printed Poly-ε-caprolactone Scaffolds Functionalized with Tricalcium Phosphate, Hydroxyapatite, Bio-Oss, or Decellularized Bone Matrix," they report on the mechanical and structural properties of the various porous scaffolds, to which they added adipose-derived stem cells. The researchers then assessed the bone-inducing properties of each hybrid scaffold, measuring osteoblast formation, calcium content, and collagen expression.

"In the continuum of materials used to regenerate bone, harnessing the power of both biomaterial scaffolds and known crystalline bone regeneration materials provides maximal flexibility in therapy," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.
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About the Journal


Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website.

About the Publisher


Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

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