Ketone drink could help diabetics by lowering blood sugar

February 13, 2018

For the first time it has been shown that drinking a ketone supplement can lower blood sugar levels, presenting a potential future method to control spikes in blood sugar experienced by diabetics.

Type 2 diabetes and obesity have reached epidemic proportions in the past few decades. These conditions are associated with high blood sugar, which can damage the vessels that supply blood to vital organs and can also increase the risk of heart disease and stroke.

Although previous studies have shown that infusing ketones into the bloodstream can reduce blood sugar levels, this study, published in the Journal of Physiology, has shown that a ketone ester supplement can also lower blood sugar levels. Researchers at the University of British Columbia and University of Oxford have demonstrated that a single drink of ketone ester enables better control of blood sugar by reducing spikes in sugar levels.

Twenty healthy individuals participated in the study and on two occasions consumed the ketone monoester supplement or a placebo after a 10-hour fast. Thirty minutes later they consumed a drink containing 75 grams of sugar (i.e., a standard oral glucose tolerance test). Blood samples were collected every 15-30 minutes throughout the entire 2.5 hours protocol for analyses of glucose, lipids, and hormones. Compared to the placebo, the blood sugar spike was reduced on the day that the individuals had consumed the ketone drink.

It should be noted that this study was conducted with healthy young individuals, to reduce the confounding influence of insulin resistance, beta-cell dysfunction, and medications, so more research is required to know whether it will apply to people with prediabetes, type 2 diabetes and obesity. The physiological mechanisms that underpin the improved blood sugar control also need to be understood.

Professor Jonathan Little, from the University of British Columbia's Okanagan Campus, was part of the research team and said:

"Our study was done in healthy young participants but if the same responses were seen in people with, or at risk for, type 2 diabetes then it is possible that a ketone monoester supplement could be used to lower glucose levels and improve metabolic health. We are working on these studies at the moment.

"The ketone supplements do not taste very good and, in order to blind the participants, we had to make a control drink that also tasted distinctly bad. It made for interesting mornings seeing how the participants would respond to the taste of their drinks!"
-end-


The Physiological Society

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.