Nav: Home

The FASEB Journal: Magnetic fields enhance bone remodeling

February 14, 2019

Since the creation of 3D-printed (3DP) porous titanium scaffolds in 2016, the scientific community has been exploring ways to improve their ability to stimulate osteogenesis, or bone remodeling. A recent study published in The FASEB Journal revealed the osteogenic potential of Static Magnetic Field (SMF) treatment for human bone-derived mesenchymal stem cells (hBMSCs) using 3DP scaffolds in vitro and in vivo.

"The reconstruction of large bone defects resulting from trauma, tumors, and infections remains a significant challenge for orthopedic surgeons," stated Hai Wang, PhD, a researcher within the Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences. "When it comes to enhancing new bone formation, SMF presents a more feasible alternative to both bone grafts and pulsed electromagnetic fields."

A group of researchers used both hBMSCs and animal models to conduct the experiment. After seeding hBMSCs onto the surfaces of 3DP scaffolds, they divided the cells into four groups, designating the first as the control. They then exposed the remaining groups to magnetic field strengths of 50, 100, and 150 milliTesla (mT), respectively, and observed these cell cultures for 14 days. In this time, bone formation potential was significantly stronger among the SMF-treated cells than the control cells. Furthermore, the groups exposed to moderate levels of SMF (100 and 150 mT) demonstrated better osteogenic markers than the group exposed to 50 mT.

For the animal experiment, researchers used a rat model with a bone defect. After separating the rats into two groups, with the first as the control, the researchers exposed the second group to a moderate level (100 mT) of SMF. After 12 weeks, the researchers observed more new bone formation in the SMF-exposed rats than the control group.

"The long-known impact of magnetic fields in bone remodeling now receives this elegant advance, providing deep insights that may translate to major clinical advances," said Thoru Pederson, PhD, Editor-in-Chief of The FASEB Journal.
-end-
This research was supported by the Fundamental Research Funds for Central Public Welfare Research Institutes, Chinese Academy of Medical Sciences; the National High-Tech R&D Program of China; Youth Foundation of Peking Union Medical College Hospital; and Science and Technology Innovation Project of Medicine and Health, Chinese Academy of Medical Sciences.

The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). The world's most cited biology journal according to the Institute for Scientific Information, it has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century. Receive monthly highlights for The FASEB Journal; subscribe at http://www.faseb.org/fjupdate.aspx.

FASEB is composed of 29 societies with more than 130,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to our societies and their members.

Federation of American Societies for Experimental Biology

Related Magnetic Fields Articles:

Visualizing strong magnetic fields with neutrons
Researchers at the Paul Scherrer Institute PSI have developed a new method with which strong magnetic fields can be precisely measured.
Scientists deepen understanding of magnetic fields surrounding Earth and other planets
Now, a team of scientists has completed research into waves that travel through the magnetosphere, deepening understanding of the region and its interaction with our own planet, and opening up new ways to study other planets across the galaxy.
Technique pulls interstellar magnetic fields within easy reach
A new, more accessible and much cheaper approach to surveying the topology and strength of interstellar magnetic fields -- which weave through space in our galaxy and beyond, representing one of the most potent forces in nature -- has been developed by researchers at the University of Wisconsin-Madison.
A bubbly new way to detect the magnetic fields of nanometer-scale particles
The method provides manufacturers with a practical way to measure and improve their control of the properties of magnetic nanoparticles for a host of medical and environmental applications.
Quantum sensing method measures minuscule magnetic fields
A new technique developed at MIT uses quantum sensors to enable precise measurements of magnetic fields in different directions.
More Magnetic Fields News and Magnetic Fields Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...