Gold nanoclusters: new frontier for developing medication for treatment of Alzheimer's disease

February 14, 2020

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) fibrillation and plaque formation. While more than 50 millions of people are devastated by AD, no treatment is available. Recently, anti-Aβ antibody-based immunotherapy has failed in clinical trials, partially due to the increased cytotoxicity of soluble Aβ oligomers. Therefore, developing a medication for AD treatment becomes an even more grave challenge.

In a new research article published in the Beijing-based National Science Review, scientists at the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology in China explored the possibility of treating with gold nanoclusters.

As illustrated in Figure 1, Au23(CR)14, a novel gold nanocluster modified with Cys-Arg (CR) dipeptide, functions in multiple stages of the progression from Aβ monomer to Aβ plaques: inhibiting the misfolding and fibrillation of amyloid-β (Aβ), fully dissolving the preformed/mature Aβ fibrils and restoring the conformation of Aβ peptides from misfolded β-sheets into unfolded monomer state with abolished cytotoxicity, and more importantly, completely dissolving endogenous Aβ plaques in the brain slices from transgenic AD model mice. Furthermore, Au23(CR)14 has good biocompatibility and infiltration ability across the blood brain barrier (BBB).

This article not only presents a compelling nanotherapeutic candidate for AD treatment, but also opens a new frontier for developing nanomaterial-based medications for AD treatment. Undoubtedly, more researches studying the basic mechanisms by which gold nanoclusters dissolve Aβ plaques will spur the development of new medications for AD treatment.
-end-
This research received funding from the National Natural Science Foundation of China (21975191, 21805218, 51873168, 81803515, 51533007 and 51521001) and the Natural Science Foundation of Hubei Province (2018CFA002 and 2018CFB348).

See the article:

Wenkang Zhang, Guanbin Gao*, Zhongjie Ma, Zhuoying Luo, Meng He, and Taolei Sun*
Au23(CR)14 Nanocluster Restores Fibril Aβ's Unfolded State with Abolished Cytotoxicity and Dissolves Endogenous Aβ Plaques
Natl Sci Rev Doi:10.1093/nsr/nwz215
https://doi.org/10.1093/nsr/nwz215

The National Science Review is the first comprehensive scholarly journal released in English in China that is aimed at linking the country's rapidly advancing community of scientists with the global frontiers of science and technology. The journal also aims to shine a worldwide spotlight on scientific research advances across China.

Science China Press

Related Medication Articles from Brightsurf:

New medication may treat underlying causes of hypertrophic cardiomyopathy
Mavacamten, a new investigational cardiac medication, may improve heart function for people with thickened heart muscle leading to obstructed blood flow through the heart, a condition known as obstructive hypertrophic cardiomyopathy.

Therapy plus medication better than medication alone in bipolar disorder
A review of 39 randomized clinical trials by scientists from UCLA and their colleagues from other institutions has found that combining the use medication with psychoeducational therapy is more effective at preventing a recurrence of illness in people with bipolar disorder than medication alone.

Kids diagnosed with ADHD often don't take medication regularly
Children diagnosed with ADHD inconsistently take their prescribed medication, going without treatment 40 per cent of the time, a new study has found.

Long-term medication for schizophrenia is safe
Researchers at Karolinska Institutet in Sweden and their colleagues in Germany, the USA and Finland have studied the safety of very long-term antipsychotic therapy for schizophrenia.

Which is more effective for treating PTSD: Medication, or psychotherapy?
A systematic review and meta-analysis led by Jeffrey Sonis, MD, MPH, of the University of North Carolina School of Medicine, finds there is insufficient evidence at present to answer that question.

ADHD medication: How much is too much for a hyperactive child?
When children with ADHD don't respond well to Methylphenidate (MPH, also known as Ritalin) doctors often increase the dose.

Pain medication use by children after common surgeries
About 400 caregivers reported pain medication use by children after common surgeries such as hernia, elbow fracture, appendectomy or adenoid removal in this study.

Bringing cancer medication safely to its destination
Treating cancer more selectively and more effectively -- this could be achieved with an innovative technology developed by teams of researchers at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Ludwig-Maximilians-Universität München (LMU).

Bullying linked to student's pain medication use
In a school-based survey study of all students in grades 6, 8, and 10 in Iceland, the use of pain medications was significantly higher among bullied students even when controlling for the amount of pain they felt, as well as age, gender, and socioeconomic status.

New medication gives mice bigger muscles
Researchers from Aarhus University, Denmark, have studied a new group of medicinal products which increase the muscle- and bone mass of mice over a few weeks.

Read More: Medication News and Medication Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.