Nav: Home

Radiotherapy for invasive breast cancer increases the risk of second primary lung cancer

February 15, 2017

DENVER - East Asian female breast cancer patients receiving radiotherapy have a higher risk of developing second primary lung cancer.

Lung cancer is the leading cause of cancer deaths worldwide, causing more deaths than breast, colon and prostate cancers combined. The risk factors for developing lung cancer include tobacco smoking, age, family history, medical or occupational radiation exposure and other chronic inflammatory diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD). Further, a history of prior cancer such as lymphoma, head and neck cancer or smoking-related cancer is considered to be a risk factor for developing second primary lung cancer (SPLC). Studies have also shown that second primary cancers, specifically esophageal cancer, can develop after receiving radiation therapy for a prior cancer. Interestingly, while radiation exposure is a known risk factor for lung cancer, it is not clear whether treatment with radiation therapy (RT) for breast cancer increases the risk of developing SPLC.

Taiwanese researchers conducted a study to evaluate whether breast cancer patients treated with RT are at greater risk for developing SPLC. The Taiwan Longitudinal Health Insurance Database (LHID), which is randomly abstracted from the National Health Insurance Research Database, was used to collect 986,713 patients with medical events from 2000 to 2010 for cohort analysis. All women with newly diagnosed invasive breast cancer, aged 18 years or older, and without other types of malignancy before 2000 or in the follow-up periods were enrolled in the study. Eligible patients were assigned to the radiation or non-radiation cohorts. Age, comorbidities, insurance premium, urbanization level, location, date of event and hospital care level were analyzed. Kaplan-Meier curve analysis and the log-rank test were used to demonstrate the cumulative risk for subsequent lung cancer. The hazard ratios of parameters were calculated by Cox regression analysis.

The results of the study published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), reported that of the 986,713 patients identified in the LHID, 7,408 female patients with breast cancer were eligible for the study. Among these, 5,696 patients underwent radiotherapy and 1,713 did not. At the end of the follow-up period, lung cancer had been diagnosed in 128 patients in the radiotherapy cohort (2.25%) and 4 patients in the non-radiation cohort (0.23%). Cox regression analysis showed that the adjusted hazard ratio was 10.08 times higher in the radiotherapy cohort than in the non-radiation cohort.

The authors comment that, "Treatment choices for breast cancer are multidisciplinary and include a combination of surgical resection, radiation, chemotherapy, hormone therapy and targeted therapy. This study investigated whether radiation, a frequently used therapeutic option for multidisciplinary treatment of breast cancer, subjected patients to a greater risk for SPLC in an East Asian country. The results of this study showed that radiation for breast cancer, which is an important treatment option, was correlated with a significant increase in the incidence of SPLC, particularly among older women or those with advanced-stage breast cancer. Regardless of the clinical or pathological stage, radiation for breast cancer also significantly increased the risk in the non-radiation cohort. Patients who undergo radiation for multidisciplinary treatment of breast cancer should be carefully monitored to detect potential SPLC."
-end-
About the IASLC

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 5,000 lung cancer specialists in over 100 countries. Visit http://www.iaslc.org for more information.

Written by: Jacinta Wiens, PhD, 720-598-1941; jacinta.wiens@iaslc.org

Media Contact: Becky Bunn, 720-254-9509; Becky.Bunn@iaslc.org

International Association for the Study of Lung Cancer

Related Breast Cancer Articles:

Does MRI plus mammography improve detection of new breast cancer after breast conservation therapy?
A new article published by JAMA Oncology compares outcomes for combined mammography and MRI or ultrasonography screenings for new breast cancers in women who have previously undergone breast conservation surgery and radiotherapy for breast cancer initially diagnosed at 50 or younger.
Blood test offers improved breast cancer detection tool to reduce use of breast biopsy
A Clinical Breast Cancer study demonstrates Videssa Breast can inform better next steps after abnormal mammogram results and potentially reduce biopsies up to 67 percent.
Surgery to remove unaffected breast in early breast cancer increases
The proportion of women in the United States undergoing surgery for early-stage breast cancer who have preventive mastectomy to remove the unaffected breast increased significantly in recent years, particularly among younger women, and varied substantially across states.
Breast cancer patients with dense breast tissue more likely to develop contralateral disease
Breast cancer patients with dense breast tissue have almost a two-fold increased risk of developing disease in the contralateral breast, according to new research from The University of Texas MD Anderson Cancer.
Some early breast cancer patients benefit more from breast conservation than from mastectomy
Breast conserving therapy (BCT) is better than mastectomy for patients with some types of early breast cancer, according to results from the largest study to date, presented at ECC2017.
One-third of breast cancer patients not getting appropriate breast imaging follow-up exam
An annual mammogram is recommended after treatment for breast cancer, but nearly one-third of women diagnosed with breast cancer aren't receiving this follow-up exam, according to new findings presented at the 2016 Annual Clinical Congress of the American College of Surgeons.
Low breast density worsens prognosis in breast cancer
Even though dense breast tissue is a risk factor for breast cancer, very low mammographic breast density is associated with a worse prognosis in breast cancer patients.
Is breast conserving therapy or mastectomy better for early breast cancer?
Young women with early breast cancer face a difficult choice about whether to opt for a mastectomy or breast conserving therapy (BCT).
Breast density and outcomes of supplemental breast cancer screening
In a study appearing in the April 26 issue of JAMA, Elizabeth A.
Full dose radiotherapy to whole breast may not be needed in early breast cancer
Five years after breast-conserving surgery, radiotherapy focused around the tumor bed is as good at preventing recurrence as irradiating the whole breast, with fewer side effects, researchers from the UK have found in the large IMPORT LOW trial.

Related Breast Cancer Reading:

Chicken Soup for the Soul: Hope & Healing for Your Breast Cancer Journey: Surviving and Thriving During and After Your Diagnosis and Treatment
by Dr. Julie Silver (Author)

Chicken Soup for the Soul: Hope & Healing for Your Breast Cancer Journey will encourage comfort and encourage breast cancer patients and survivors with its inspiring stories and helpful medical information.

A support group from breast cancer diagnosis through treatment to rehabilitation and recovery, this book combines inspiring Chicken Soup for the Soul stories written just for this book and accessible leading-edge medical information from Dr. Julie Silver of Harvard Medical School. Patients and survivors will find comfort, strength and hope. View Details


Dear Friend: Letters of Encouragement, Humor, and Love for Women with Breast Cancer
by Gina L Mulligan (Author)

This beautiful collection of handwritten letters offers strength, encouragement, and comfort to women living with breast cancer. Written by compassionate strangers—many of whom have gone through their own health battles—these heartfelt letters were gathered by Girls Love Mail, an organization that provides support to people diagnosed with breast cancer as seen on NBC Nightly News. Presented in an elegant package with metallic endpapers, and a ribbon marker, and brimming with warm messages of empathy, inspiration, and humor, Dear Friend delivers words of wisdom when they're needed... View Details


Let Me Get This Off My Chest: A Breast Cancer Survivor Over-Shares
by Margaret Lesh (Author)

Tamoxifen hot flashes, mastectomy, reconstruction, breast cancer etiquette, Frankenboobs, bras with special attachments—Margaret Lesh shares all in her funny, heartfelt collection of essays, anecdotes, and life lessons from the perspective of a two-time breast cancer survivor. She’ll tell you when it’s okay to play the cancer card, what you should take to the hospital, and gives suggestions on how to cope in those dark moments of the soul. With practical tips sprinkled throughout, LET ME GET THIS OFF MY CHEST explores how breast cancer changed her outlook on life, offering honest... View Details


The Breast Cancer Survival Manual, Sixth Edition: A Step-by-Step Guide for Women with Newly Diagnosed Breast Cancer
by John Link M.D. (Author), James Waisman M.D. (Author), Nancy Link R.N. (Author)

One of the most comprehensive and bestselling books on breast cancer treatment and survival, completely revised and updated

The sixth edition of Breast Cancer Survival Manual provides essential updates on treatment and care, enhancing the basic information that has made this the most trusted guide for women diagnosed with breast cancer for the past two decades. This edition includes the most current advice on:
· The new genomic classification of breast cancer and its importance in treatment planning
· Cancer gene testing, which determines if a woman will benefit... View Details


Dr. Susan Love's Breast Book (A Merloyd Lawrence Book)
by Susan M. Love (Author), Karen Lindsey (Contributor), Elizabeth Love (Contributor)

For a woman faced with a diagnosis of breast cancer, the information available today is vast, uneven, and confusing. For more than two decades, readers have relied on Dr. Susan Love's Breast Book to guide them through this frightening thicket of research and opinion to find the best possible options for their particular situations. This sixth edition explains exciting advances in targeted treatments, hormonal therapies, safer chemotherapy, and immunologic approaches as well as new forms of surgery and radiation. There is extensive guidance for the increasing number of women living for... View Details


Breast Cancer Smoothies: 100 Delicious, Research-Based Recipes for Prevention and Recovery
by Daniella Chace (Author)

The statistics are staggering. Breast cancer is the most common type of cancer among women--About 1 in 8 U.S. women (about 12%) will develop invasive breast cancer over the course of her lifetime. Second only to heart disease by a mere one percent, every ounce of prevention and every window of opportunity for healing is critical. In order to reduce the risk of developing this common disease, you need a targeted plan to protect yourself from common breast toxins and to strengthen your immune defenses.

In her delightful new book, Daniella breaks down the complex topic of... View Details


Heal Breast Cancer Naturally: 7 Essential Steps to Beating Breast Cancer
by Dr. Veronique Desaulniers (Author)

One out of eight women will be diagnosed with Breast Cancer. One out of 3 women will experience some form of cancer in their life time.

I was one of those statistics even though I was living a healthy lifestyle that consisted of organic foods, regular exercise, massage, Chiropractic care and colonics. How could somebody like me develop Breast Cancer?

That very question led to thousands of hours of research, study, soul-searching and prayer. It all came together as The 7 Essentials – 7 basic steps that are necessary for preventing and healing cancer, or any dis-ease for... View Details


Getting Things Off My Chest: A Survivor's Guide to Staying Fearless and Fabulous in the Face of Breast Cancer
by Melanie Young (Author)

Charge head on into the battle with breast cancer, armed with these outstanding survivors' tips on how to stay sane, focused, and in charge. Written by a breast cancer survivor with expert insights, handy checklists and helpful questions to ask your doctors, all geared toward streamlining your new life. This detailed, upbeat book helps you make informed decisions, eat and exercise to stay strong, look and feel your best, eliminate stress and boost your spirits with positive thinking and a dose of humor. Don't let your cancer control you; empower yourself and ease the transition with this... View Details


Breast Cancer Husband: How to Help Your Wife (and Yourself) during Diagnosis, Treatment and Beyond
by Marc Silver (Author)

A unique guide, like none other on the market-packed with medical information, practical tips, psychological insight, and coping strategies-to help men help the women they love through this trying time.

When Marc Silver became a breast cancer husband three years ago, he learned firsthand how frightened and helpless the breast cancer husband feels. He searched in vain for a book that would give him the information and advice he so desperately sought. Now this award-winning journalist has compiled just the kind of emotionally supportive and useful resource that he wished he had been... View Details


Beat Breast Cancer: 19 Actions to Help You Through Diagnosis, Surgery and Beyond
by M.K. Caldwell (Author)

I am a cancer survivor. This book is for those who are facing the news of cancer, or for someone who knows someone who is fighting this fight and wants to give this book to them as a gift. A diagnosis of cancer is overwhelmingly terrible. However, the outcome can be a very successful one. Surprisingly, conquering cancer can positively change your future life for the better.What? Yes. In the darkest of hours, there is a silver lining, always. I think you will find this book to be true to life. While the news is devastating, attitude and action are everything! After I cried, I ended up... View Details

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Peering Deeper Into Space
The past few years have ushered in an explosion of new discoveries about our universe. This hour, TED speakers explore the implications of these advances — and the lingering mysteries of the cosmos. Guests include theoretical physicist Allan Adams, planetary scientist Sara Seager, and astrophysicists Natasha Hurley-Walker and Jedidah Isler.
Now Playing: Science for the People

#461 Adhesives
This week we're discussing glue from two very different times. We speak with Dr. Jianyu Li about his research into a new type of medical adhesive. And Dr. Geeske Langejans explains her work making and investigating Stone Age and Paleolithic glues.