Short kids may have higher future stroke risk

February 15, 2018

DALLAS, Feb. 15, 2018 - Being a short kid is associated with increased risk of having a stroke in adulthood, according to Danish research published in Stroke, an American Heart Association journal.

A prospective study examined data on more than 300,000 Danish schoolchildren - born between 1930-1989 who were examined at ages 7, 10 and 13. Researchers noted that boys and girls who were 2 to 3 inches shorter than average for their age were at increased risk of clot-related (ischemic) stroke in adult men and women and of bleeding stroke in men.

While adult height is genetically determined, it is also influenced by factors such as maternal diet during pregnancy, childhood diet, infection and psychological stress. Several of these factors are modifiable and all are thought to affect the risk of stroke.

Researchers noted that a decline in stroke incidence and mortality rates in most high-income countries, primarily in women, occurred simultaneously with a general increase in attained adult height. Taken together, this suggests the involvement of shared underlying mechanisms for height and stroke development.

Researchers say these results have implications for understanding disease origin rather than for clinical risk prediction and future studies should focus on the mechanisms underlying the relationship between childhood height and later stroke.

"Our study suggests that short height in children is a possible marker of stroke risk and suggests these children should pay extra attention to changing or treating modifiable risk factors for stroke throughout life to reduce the chances of having this disease," said senior study author Jennifer L. Baker, Ph.D., associate professor in the Center for Clinical Research and Prevention at Bispebjerg and Frederiksberg Hospital and Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, at the University of Copenhagen, in Denmark.
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Funding sources and author disclosures are detailed in the manuscript.

Additional Resources: Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at http://www.heart.org/corporatefunding.

About the American Heart Association

The American Heart Association is devoted to saving people from heart disease and stroke - the two leading causes of death in the world. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat these diseases. The Dallas-based association is the nation's oldest and largest voluntary organization dedicated to fighting heart disease and stroke. To learn more or to get involved, call 1-800-AHA-USA1, visit heart.org or call any of our offices around the country. Follow us on Facebook and Twitter.

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