Breakthrough in organic chemistry: Asymmetric syntheses of useful, unique chiral compounds

February 16, 2021

Atropisomers are a class of stereoisomers (chemical compounds that differ in spatial arrangement of atoms) arising from restricted rotation around a single bond and have various applications in chemistry. To date, most research on atropisomers has focused on "biaryl atropisomers" (due to the rotational restriction around a carbon-carbon bond), but it is also possible for atropisomers to arise from rotational restrictions around a nitrogen-carbon (N-C) bond. These N-C axially chiral compounds are found in various natural products and bioactive compounds and thus have promising applications in medicine and agriculture. Furthermore, these are known to be useful as chiral building blocks and chiral ligands.

Of course, before researchers can take advantage of any such applications, they need to develop a feasible method for synthesizing it. "Although a number of bioactive compounds and natural products possessing an N-C axially chiral structure have recently been found, no efficient synthetic method was known," notes Professor Osamu Kitagawa from Shibaura Institute of Technology (SIT), Japan. To address this problem, Prof. Kitagawa and his team have spent the past few decades developing efficient methods for the synthesis of N-C axially chiral compounds. In a paper recently published in Accounts of Chemical Research, Prof Kitagawa summarizes his team's achievements since 2002.

In 2001, Prof. Kitagawa's group started investigating a never-before-attempted catalytic asymmetric synthesis of ortho-tert-butyl anilides and other N-C axially chiral compounds. In 2005, they found that reacting achiral secondary ortho-tert-butylanilides with 4-iodonitrobenzene in the presence of a chiral palladium (Pd) catalyst (catalytic enantioselective aromatic amination) resulted in the highly enantioselective (asymmetric) synthesis of N-C axially chiral N-arylated ortho-tert-butylanilides. They next experimented with adapting this intermolecular N-arylation reaction for use in intramolecular reactions, and their efforts led to the synthesis of compounds called "N-C axially chiral lactams" (which had high optical purities). Importantly, these reactions represented the first enantioselective syntheses of N-C axially chiral compounds with a chiral catalyst.

The investigators continued their work by using chiral Pd-catalyzed intramolecular N-arylations to achieve the enantioselective syntheses of N-C axially chiral quinoline-4-one and phenanthridin-6-one derivatives. They also used various chiral Pd-catalyzed reactions to prepare optically active N-C axially chiral compounds called N-(2-tert-butylphenyl)indoles, 3-(2-bromophenyl)quinazolin-4-ones, and N-(2-tert-butylphenyl)sulfonamides. Prof Kitagawa's research has led to the successful synthesis of potentially useful compounds, such as an N-C axially chiral mebroqualone that acts as an agonist of specific receptors present in the brain, called "GABA receptors" (and has potential therapeutic properties).

In fact, since 2005, the enantioselective synthesis of N-C axially chiral compounds has become a topic of considerable interest to chemists outside of Prof. Kitagawa's research team. For example, the literature on the synthesis of axially chiral anilides with catalytic enantioselective aromatic aminations dates back to 2005, with a research paper by Prof. Kitagawa's team, but since then, other research groups have published more than 70 original papers concerning highly enantioselective synthesis of various N-C axially chiral compounds using chiral catalysts. Further, the team's 2010 paper on the catalytic enantioselective synthesis of N-C axially chiral indoles represented an important contribution to the development of axially chiral indole chemistry, and various research groups have since developed catalytic asymmetric syntheses for various indole derivatives that include a C?C chiral axis or an N-C chiral axis. Prof. Kitagawa himself sees his laboratory's work as having important applications to "the synthesis of optically active drug compounds and natural products with N-C axial chirality."

In conclusion, Prof. Kitagawa's research team has succeeded in devising catalytic enantioselective syntheses of N-C axially chiral compounds. This work has inspired other research teams to make further contributions in the same field and has led to workable synthetic pathways for bioactive compounds with potential medicinal value. Prof Kitagawa predicts that the catalytic asymmetric synthesis of N-C axially chiral compounds will continue to draw attention, thanks to the potential uses of such compounds across a broad range of fields.
-end-
Reference

Title of original paper: Chiral Pd-Catalyzed Enantioselective Syntheses of Various N-C Axially Chiral Compounds and Their Synthetic Applications

Journal: Accounts of Chemical Research

DOI: 10.1021/acs.accounts.0c00767

About Shibaura Institute of Technology (SIT), Japan

Shibaura Institute of Technology (SIT) is a private university with campuses in Tokyo and Saitama. Since the establishment of its predecessor, Tokyo Higher School of Industry and Commerce, in 1927, it has maintained "learning through practice" as its philosophy in the education of engineers. SIT was the only private science and engineering university selected for the Top Global University Project sponsored by the Ministry of Education, Culture, Sports, Science and Technology and will receive support from the ministry for 10 years starting from the 2014 academic year. Its motto, "Nurturing engineers who learn from society and contribute to society," reflects its mission of fostering scientists and engineers who can contribute to the sustainable growth of the world by exposing their over 8,000 students to culturally diverse environments, where they learn to cope, collaborate, and relate with fellow students from around the world.

Website: https://www.shibaura-it.ac.jp/en/

About Professor Osamu Kitagawa from SIT, Japan

Dr. Osamu Kitagawa received his BS and PhD from the Tokyo University of Pharmacy and Life Science (then called the Tokyo College of Pharmacy) in 1984 and 1989, respectively. He worked as an assistant, a lecturer, and an associate professor at the same university before moving to Shibaura Institute of Technology in 2008. He was promoted to full professor in 2010. His research interests include the chemistry of novel stereoisomeric molecules and development of novel synthetic organic reactions. He has authored 100 articles and has received over 3250 citations.

Funding information

This study was funded by the Research Foundation for Pharmaceutical Sciences and the Japan Society for the Promotion of Science.

Shibaura Institute of Technology

Related Chemistry Articles from Brightsurf:

Searching for the chemistry of life
In the search for the chemical origins of life, researchers have found a possible alternative path for the emergence of the characteristic DNA pattern: According to the experiments, the characteristic DNA base pairs can form by dry heating, without water or other solvents.

Sustainable chemistry at the quantum level
University of Pittsburgh Associate Professor John A. Keith is using new quantum chemistry computing procedures to categorize hypothetical electrocatalysts that are ''too slow'' or ''too expensive'', far more thoroughly and quickly than was considered possible a few years ago.

Can ionic liquids transform chemistry?
Table salt is a commonplace ingredient in the kitchen, but a different kind of salt is at the forefront of chemistry innovation.

Principles for a green chemistry future
A team led by researchers from the Yale School of Forestry & Environmental Studies recently authored a paper featured in Science that outlines how green chemistry is essential for a sustainable future.

Sugar changes the chemistry of your brain
The idea of food addiction is a very controversial topic among scientists.

Reflecting on the year in chemistry
A lot can happen in a year, especially when it comes to science.

Better chemistry through tiny antennae
A research team at The University of Tokyo has developed a new method for actively controlling the breaking of chemical bonds by shining infrared lasers on tiny antennae.

Chemistry in motion
For the first time, researchers have managed to view previously inaccessible details of certain chemical processes.

Researchers enrich silver chemistry
Researchers from Russia and Saudi Arabia have proposed an efficient method for obtaining fundamental data necessary for understanding chemical and physical processes involving substances in the gaseous state.

The chemistry behind kibble (video)
Have you ever thought about how strange it is that dogs eat these dry, weird-smelling bits of food for their entire lives and never get sick of them?

Read More: Chemistry News and Chemistry Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.