New study reports activated B. infantis EVC001 improves health outcomes in preterm infants

February 16, 2021

DAVIS, Calif., Feb 16, 2021 - Researchers publishing in the peer-review journal Frontiers in Pediatrics report that pre-term infants fed Bifidobacterium longum subsp. infantis (activated B. infantis EVC001) experienced significantly lower level of intestinal inflammation, 62% less diaper rash, and required 62% fewer antibiotics- all of which are critical health indicators in neonatal care.

The study, Impact of probiotic B. infantis EVC001 feeding in premature infants on the gut microbiome, nosocomially acquired antibiotic resistance, and enteric inflammation, is the first to quantify the impact of feeding B. infantis EVC001 on key health indicators specifically in pre-term infants. The work was conducted at two neonatal intensive care units (NICU) in Southern California.

"Neonatologists, neonatal nurses and other hospital-based clinical staff are acutely focused on affecting the factors that positively impact quality of care and length of stay among pre-term infants," said Dr. Karl Sylvester, Pediatric Surgeon, Stanford, California. "This study provides compelling evidence that feeding B. infantis EVC001 to preterm infants, along with human milk, yields meaningful reduction in gut dysbiosis, antibiotic resistant gene abundance and enteric inflammation - all leading health indicators that are linked to key health outcomes."

The study included 77 infants born before 39 weeks gestational age. One group of infants, born at less than 32 weeks, was fed B. infantis EVC001. The other group, born after 32 weeks, did not receive the probiotic. Researchers gathered fecal samples from each infant over the duration of stay in the NICU to assess gut microbial composition and development, as well as enteric inflammation.

The infants who received B. infantis EVC001 experienced far lower levels of pathogenic bacteria, including Escherichia and Staphylococcus epidermidis, known to cause enteric inflammation. The B. infantis EVC001 group also experienced substantially lower levels of IL-8 and TNF-α, both of which are proinflammatory cytokines; as well as a 1.5-fold lower level of fecal calprotectin.

The study group who received B. infantis EVC001 also experienced 62 percent less diaper rash and 62 percent less antibiotic exposure than those who did not; and they experienced an 81% percent reduction in antibiotic resistant genes, the majority of which are known to be present in Enterobacteria such as Klebsiella and E. coli. These species of bacteria are associated with necrotizing enterocolitis (NEC), the leading cause of death from gastrointestinal disease in preterm infants.

"EVC001 and breastmilk combine to restore a healthy microbiome, create a protective environment in the preterm infant gut and improve clinical outcomes," said David Kyle, PhD, Chairman and Chief Scientific Officer, Evolve BioSystems, Inc. "We've observed significant benefits with EVC001 in term infants both in clinical studies and at home use. These new data in preterm infants is unequivocal, and we believe should be considered for widespread acceptance as Standard of Care in the NICU."
About Evolve BioSystems, Inc.


Related Activated Articles from Brightsurf:

Shape matters for light-activated nanocatalysts
Points matter when designing nanoparticles that drive important chemical reactions using the power of light, according research from Rice University's Laboratory for Nanophotonics.

Development of a novel approach 'Tracing Retrogradely the Activated Cell Ensemble'
The neural circuitry teams at DANDRITE and PROMEMO introduce a novel approach in their latest publication, which selectively labels sensory inputs that are activated by a defined stimulus and directed to a region of interest in the brain.

Bacteria killed by new light-activated coating
A new coating that activates in low intensity light to kill bacteria such as Staphylococcus aureus and Escherichia coli has been developed by a UCL-led team of researchers.

Pathogenic Alzheimer's disease cascade is activated by faulty norepinephrine signaling
Preclinical experiments have revealed a key missing piece of the Alzheimer's disease puzzle.

Pioneering red light-activated anti-tumor prodrug reduces side effects
Phorbiplatin, a new anti-cancer prodrug that can be controllably activated by red light was developed by a research team from City University of Hong Kong.

Light-activated metal catalyst destroys cancer cells' vital energy source
A space-age metal that formed part of the asteroid that destroyed the dinosaurs could provide a new method of treating cancer tumors selectively using light.

High magnetic field of 10T during activated carbon production improves micropore capacity by 35%
Carbon materials such as nanotubes, graphene, activated carbon and graphite are in high demand.

Key acid-activated protein channel identified
Johns Hopkins researchers have discovered a long-sought protein, the proton-activated chloride channel (PAC), that is activated in acidic environments and could protect against the tissue-damaging effects of stroke, heart attack, cancer and inflammation.

A light-activated remote control for cells
What if doctors had a remote control that they could use to steer a patient's own cells to a wound to speed up the healing process?

Pitt bioengineers create ultrasmall, light-activated electrode for neural stimulation
In a recently published paper, the University of Pittsburgh's Takashi D.

Read More: Activated News and Activated Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to