Protein linked to development of asthma

February 20, 2015

Researchers at the Medical College of Wisconsin (MCW) have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children.

The findings are published in the Journal of Biological Chemistry.

Brian F. Volkman, PhD, professor of biochemistry; and Mitchell H. Grayson, MD, associate professor of allergy and immunology; are the lead researchers on the study.

Asthma is a chronic disease of the airways that affects more than 300 million people worldwide. It is the number one illness leading to school absences in children, and accounts for more than 1.8 million emergency room visits annually. There is no cure; all current therapies focus on providing symptomatic relief and reducing the number and severity of attacks.

"Understanding the molecular mechanisms by which asthma develops and establishes itself as a chronic disease is key to elucidating alternative and potentially curative therapies," said Dr. Grayson.

The researchers previously found evidence linking a human chemokine (protein) called CCL28 to the development of chronic asthma. This study is the first, however, that examines structural analysis and its impact on disease development.

"We found that even in the absence of a viral infection, CCL28 can play a role in the induction of asthma pathology--when the protein is natively folded. If unfolded, it does not," explained Dr. Volkman. "We propose that by exploiting the unique structural features of CCL28, potent and specific CCL28 inhibitors may be developed. This work is the first step in generating a novel type of asthma therapy that may have the power to prevent development of post-viral asthma in young children."
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Additional authors of the paper are Monica A. Thomas, medical scientist training student; Becky Buelow, MD, allergist; Amanda Nevins, graduate student in biochemistry; Stephanie Jones, medical student; Francis Peterson, PhD, associate professor of biochemistry; and Rebekah Gundry, PhD, assistant professor of biochemistry; all of MCW.

Medical College of Wisconsin

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