Neuronal stimulation regulates appetite and glucose levels in mice

February 20, 2017

Drugs that target signaling by glucagon-like peptide (GLP-1) in the gut and pancreas are commonly used to regulate hypoglycemia in patients with type II diabetes. However, these drugs are associated with a number of unpleasant side effects that may be linked to other targets of GLP-1 signaling. A subset of neurons in the brain also produces GLP-1 and related peptides, but how brain-mediated GLP-1 signaling influences metabolism and appetite is not clear. This week in the JCI, a study led by Michael Scott at the University of Virginia explores how stimulation of GLP-1-producing neurons can control appetite and glucose levels in mice. The researchers selectively excited GLP-1 neurons in the hypothalamus of mice and found that the stimulation reduced animals' food intake and suppressed the generation of glucose from energy reserves. However, the stimulation's effects on glucose handling varied between lean and obese mice--in obese mice, exciting GLP-1 neurons suppressed appetite without changing glucose levels. The finding suggests that distinct pathways with different sensitivities to individual metabolic state may mediate the behavioral and physiological effects of GLP-1 signaling.
TITLE: Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight


Michael M. Scott
University of Virginia Health System

View this article at:


TITLE: DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain


David D'Alessio
Duke University

View this article at:

JCI Journals

Related Neurons Articles from Brightsurf:

Paying attention to the neurons behind our alertness
The neurons of layer 6 - the deepest layer of the cortex - were examined by researchers from the Okinawa Institute of Science and Technology Graduate University to uncover how they react to sensory stimulation in different behavioral states.

Trying to listen to the signal from neurons
Toyohashi University of Technology has developed a coaxial cable-inspired needle-electrode.

A mechanical way to stimulate neurons
Magnetic nanodiscs can be activated by an external magnetic field, providing a research tool for studying neural responses.

Extraordinary regeneration of neurons in zebrafish
Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

Dopamine neurons mull over your options
Researchers at the University of Tsukuba have found that dopamine neurons in the brain can represent the decision-making process when making economic choices.

Neurons thrive even when malnourished
When animal, insect or human embryos grow in a malnourished environment, their developing nervous systems get first pick of any available nutrients so that new neurons can be made.

The first 3D map of the heart's neurons
An interdisciplinary research team establishes a new technological pipeline to build a 3D map of the neurons in the heart, revealing foundational insight into their role in heart attacks and other cardiac conditions.

Mapping the neurons of the rat heart in 3D
A team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time.

How to put neurons into cages
Football-shaped microscale cages have been created using special laser technologies.

A molecule that directs neurons
A research team coordinated by the University of Trento studied a mass of brain cells, the habenula, linked to disorders like autism, schizophrenia and depression.

Read More: Neurons News and Neurons Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to