Nav: Home

An intricate interaction: dietary fatty acid intake influences hypertension risk

February 20, 2019

Kanazawa, Japan - Hypertension is an important public health problem that can lead to life-threatening cardiovascular events, including heart attack and stroke. Many studies have attempted to understand the complex relationship between dietary factors and hypertension; none have provided a clear explanation of the interaction between hypertension and dietary intake of n-6 fatty acids (a building block of fat), until now.

In a new study published in Nutrients, a research team from Kanazawa University investigated the relationship between dietary intake of n-6 fatty acids and hypertension, using blood pressure measurement and a diet history questionnaire, and found that the relationship between dietary intake of n-6 fatty acids and hypertension was influenced by diabetes status.

"There have been conflicting reports of the relationship between dietary intake of n-6 fatty acids and risk of hypertension," says Hiroyuki Nakamura, corresponding author on the study. "Metabolites of n-6 fatty acids can lower blood pressure in a manner influenced by blood glucose levels. Therefore, we suspected that the relationship between dietary intake of n-6 fatty acids and risk of hypertension might be affected by glucose tolerance, which is impaired in patients with diabetes."

In the study, the researchers found that the relationship between dietary intake of n-6 fatty acids and hypertension differed according to whether subjects had diabetes; in healthy subjects, high intake of n-6 fatty acids was significantly associated with hypertension, whereas high intake of n-6 fatty acids was inversely associated with hypertension in subjects with diabetes.

"Our analyses revealed a relationship between dietary intake of n-6 fatty acids and glycated hemoglobin in the blood (our definition of diabetes), which has not been previously established," says Haruki Nakamura, lead author on the study. "A previous meta-analysis showed that higher intake of a diet rich in linoleic acid (the main fatty acid in the n-6 fatty acids class) was significantly associated with higher risks of death from all causes, cardiovascular disease, and coronary heart disease in subjects with cardiovascular disease. Therefore, our results indicate that n-6 fatty acid intake may have no cardiovascular benefit in subjects who are at risk for cardiovascular disease or diabetes."

In addition to the reduction of hypertension associated with increased dietary intake of n-6 fatty acids by healthy individuals, the researchers showed no benefit, and possible hypertension-related harm, from increased dietary intake of n-6 fatty acids by patients with diabetes.

Hypertension is an important risk factor for a variety of destructive cardiovascular injuries. This study showed that increased dietary intake of n-6 fatty acids could positively impact the risk of hypertension, but that this benefit is limited to individuals who do not have impaired glucose tolerance.
-end-


Kanazawa University

Related Diabetes Articles:

The role of vitamin A in diabetes
There has been no known link between diabetes and vitamin A -- until now.
Can continuous glucose monitoring improve diabetes control in patients with type 1 diabetes who inject insulin
Two studies in the Jan. 24/31 issue of JAMA find that use of a sensor implanted under the skin that continuously monitors glucose levels resulted in improved levels in patients with type 1 diabetes who inject insulin multiple times a day, compared to conventional treatment.
Complications of type 2 diabetes affect quality of life, care can lead to diabetes burnout
T2D Lifestyle, a national survey by Health Union of more than 400 individuals experiencing type 2 diabetes (T2D), reveals that patients not only struggle with commonly understood complications, but also numerous lesser known ones that people do not associate with diabetes.
Type 2 diabetes and obesity -- what do we really know?
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world.
A better way to predict diabetes
An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.
The Lancet Diabetes & Endocrinology: Older Americans with diabetes living longer without disability, US study shows
Older Americans with diabetes born in the 1940s are living longer and with less disability performing day to day tasks than those born 10 years earlier, according to new research published in The Lancet Diabetes & Endocrinology journal.
Reverse your diabetes -- and you can stay diabetes-free long-term
A new study from Newcastle University, UK, has shown that people who reverse their diabetes and then keep their weight down remain free of diabetes.
New cause of diabetes
Although insulin-producing cells are found in the endocrine tissue of the pancreas, a new mouse study suggests that abnormalities in the exocrine tissue could cause cell non-autonomous effects that promotes diabetes-like symptoms.
The Lancet Diabetes & Endocrinology: Reducing sugar content in sugar-sweetened drinks by 40 percent over 5 years could prevent 1.5 million cases of overweight and obesity in the UK and 300,000 cases of diabetes
A new study published in The Lancet Diabetes & Endocrinology journal suggests that reducing sugar content in sugar sweetened drinks (including fruit juices) in the UK by 40 percent over five years, without replacing them with any artificial sweeteners, could prevent 500,000 cases of overweight and 1 million cases of obesity, in turn preventing around 300,000 cases of type 2 diabetes, over two decades.
Breastfeeding lowers risk of type 2 diabetes following gestational diabetes
Women with gestational diabetes who consistently and continuously breastfeed from the time of giving birth are half as likely to develop type 2 diabetes within two years after delivery, according to a study from Kaiser Permanente published today in Annals of Internal Medicine.

Related Diabetes Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#529 Do You Really Want to Find Out Who's Your Daddy?
At least some of you by now have probably spit into a tube and mailed it off to find out who your closest relatives are, where you might be from, and what terrible diseases might await you. But what exactly did you find out? And what did you give away? In this live panel at Awesome Con we bring in science writer Tina Saey to talk about all her DNA testing, and bioethicist Debra Mathews, to determine whether Tina should have done it at all. Related links: What FamilyTreeDNA sharing genetic data with police means for you Crime solvers embraced...