Nav: Home

How obesity affects vitamin D metabolism

February 21, 2019

A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.

The study reveals that obese mice have very low levels of the enzyme in the liver that converts vitamin D into 25-hydroxyvitamin D (calcidiol), which is the major form of vitamin D in the blood. Therefore, it may be more effective to treat vitamin D insufficiency in obese individuals with calcidiol rather than with other forms of vitamin D.

"Low circulating levels of 25-hydroxyvitamin D are common in obesity and have been attributed to sequestration of vitamin D in fat cells. Here we propose a second mechanism with greater biological implications: obesity reduces the ability of the liver to convert vitamin D into 25-hydroxyvitamin D," said lead author Dr. Jeffrey Roizen, of The Children's Hospital of Philadelphia. "Our observations show that this early step in activating vitamin D is influenced by obesity, and suggest that obesity-related effects on the liver can have clinically important systemic effects on bone and mineral metabolism. Further, while we often think of low vitamin D causing obesity, this work shows that an illness or pathology (like obesity) can cause low vitamin D."
-end-


Wiley

Related Obesity Articles:

Obesity is in the eye of the beholder
Doctors have a specific definition of what it means to be overweight or obese, but in the social world, gender, race and generation matter a lot for whether people are judged as 'thin enough' or 'too fat.'
Type 2 diabetes and obesity -- what do we really know?
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world.
Three in 4 don't know obesity causes cancer
Three out of four (75 percent) people in the UK are unaware of the link between obesity and cancer, according to a new Cancer Research UK report published today.
Obesity on the rise in Indonesia
Obesity is on the rise in Indonesia, one of the largest studies of the double burden of malnutrition in children has revealed.
Obesity rates are not declining in US youth
A clear and significant increase in obesity continued from 1999 through 2014, according to an analysis of data on United States children and adolescents age 2 to 19 years.
How does the environment affect obesity?
Researchers will be examining how agricultural and food processing practices may affect brown fat activity directly or indirectly.
Obesity Day to highlight growing obesity epidemic in Europe
The growing obesity epidemic, which is predicted to affect more than half of all European citizens by 2030, will be the focus of European Obesity Day to be held on May 21.
Understanding obesity from the inside out
Researchers developed a new laboratory method that allowed them to identify GABA as a key player in the complex brain processes that control appetite and metabolism.
Epigenetic switch for obesity
Obesity can sometimes be shut down.
Immunological Aspects of Obesity
This FASEB Conference focuses on the interactions between obesity and immune cells, focusing in particular on how inflammation in various organs influences obesity and obesity-related complications.

Related Obesity Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#530 Why Aren't We Dead Yet?
We only notice our immune systems when they aren't working properly, or when they're under attack. How does our immune system understand what bits of us are us, and what bits are invading germs and viruses? How different are human immune systems from the immune systems of other creatures? And is the immune system so often the target of sketchy medical advice? Those questions and more, this week in our conversation with author Idan Ben-Barak about his book "Why Aren't We Dead Yet?: The Survivor’s Guide to the Immune System".