Towards A Local Stimulation Of Natural Bypass Growth - Max Planck Scientists Developed New Treatment For Ischemic Heart Disease

February 23, 1998

Enhancing the bodies ability to create its own natural bypasses may soon become an alternative to baloon dilatation or bypass surgery. As reported in the February edition of Nature Biotechnology, scientists at the Max Planck Institute for Physiological and Clinical Research in Bad Nauheim/Germany have recently developed a non-invasive method to supply the diseased heart with vessel growth promoting factors making use of the property of microscopic beads to lodge in the peripheral vasculature. These beads are made to slowly release the growth factor without causing any damage.

Different growth factors have already been shown to promote the growth of new vessels. In particular Vascular Endothelial Growth Factor and Fibrobroblast Growth Factors have been subject to extensive research. However, whereas genes or proteins of these growth factors can simply be injected into peripheral tissues this is not possible in case of the heart. A systemic injection may also be deleterious since all of these growth factors have been shown to cause acute vascodilatation and may also promote tumor vessel growth. Attempts of vessel growth promoting therapies in the heart have therefore mainly been limited to cardiac surgery where the gene of a growth factor was given as adjunct to bypass surgery. The new method developed by Arras and collegues on the contrary requires only a routine catheterization procedure. Microscopic beads are injected into the vessel supplying the diseased territory and lodge in the peripheral capillary system whithout causing any damage. At this site they release the growth factor over a period of 7 days.

The major drawback of this method is that the growth factor will only be released within the diseased heart but not at the interface between healthy and diseased heart where large natural bypasses grow from smallest preexisting connections which are however large enough for the microscopic beads to pass through. The current method therefore is mainly suitable for situation in which many small vessels are diseased but not for bypassing a large stenosing coronary vessel.

The scientists at the Max Planck Instiute for Physiological and Clinical Research are currently directing their research efforts in deciphering the mechanism by which specialized blood cells locally adhere, release growth factors to preexisting connections between diseased and healthy areas of the heart, and thus stimulate the growth of true natural bypasses at exactly the location where it is needed.
-end-


Max-Planck-Gesellschaft

Related Bypass Surgery Articles from Brightsurf:

Strict diet explains metabolic effect of gastric bypass surgery
In many studies, bariatric surgery has been highlighted as an almost magical method for weight loss and reversing type 2 diabetes.

Opium linked with more deaths after bypass surgery
The largest study on opium use and outcomes after bypass surgery has found that - in contrast to widely held beliefs - it is linked with more deaths and heart attacks.

Use of radial artery in heart bypass surgery improves patient outcomes
Patients undergoing heart bypass surgery lived longer and had better outcomes when surgeons used a segment of an artery from their arm, called the radial artery, instead of a vein from their leg, called the saphenous vein, to create a second bypass, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).

Gastric bypass surgery may benefit muscle strength more than previously thought
Gastric bypass surgery improves relative muscle strength and physical performance in people with obesity, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Gastric bypass surgery associated with greater weight loss in adults
Adults with severe obesity had greater initial and sustained weight loss with gastric bypass surgery than either sleeve gastrectomy or adjustable gastric banding, according to a new study published today in the Annals of Internal Medicine.

Benefits of gastric bypass surgery linked to changes in sweet taste preference
Worldwide, the number of patients struggling with obesity is rapidly increasing in both adults and children.

Could drugs replace gastric bypass surgery?
Gastric bypass surgery is one of the most successful treatments for obesity and related disorders; however, some patients may not want to undergo surgery.

Diabetes reversal after bypass surgery linked to changes in gut microorganisms
Studies have shown that bariatric surgery can lead to remission of type 2 diabetes mellitus (T2DM) in rodents and humans, but this beneficial effect cannot be explained solely by weight loss.

Gastric bypass surgery at ages older than 35 years associated with improved survival
Lance E. Davidson, Ph.D., of Brigham Young University, Provo, Utah, and colleagues examined whether gastric bypass surgery is equally effective in reducing mortality in groups undergoing surgery at different ages.

High rate of symptoms, hospitalization following gastric bypass surgery for obesity
Although the vast majority of patients reported improved well-being after Roux-en-Y gastric bypass (RYGB) surgery, the prevalence of symptoms such as abdominal pain and fatigue were high and nearly one-third of patients were hospitalized, according to a study published online by JAMA Surgery.

Read More: Bypass Surgery News and Bypass Surgery Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.