Nav: Home

Reduced stress changes profile of various lipid compounds

February 25, 2020

Reduced stress is linked to changes in the profile of plasma metabolites, a new study from the University of Eastern Finland shows. According to the researchers, the findings can shed light on the associations of psychological well-being with metabolism and the risk of disease. The study was published in Scientific Reports.

Psychological stress is known to be associated with obesity, low-grade inflammation and metabolic disorders, but the underlying mechanisms remain poorly understood. In the newly published study, the researchers used metabolite profiling to study whether improved psychological well-being is associated with measurable changes in metabolism. The study is a sub-study of Elixir, a large multi-centre lifestyle intervention study conducted by the Universities of Helsinki, Eastern Finland and Jyväskylä, and the Finnish Institute of Occupational Health.

The study participants were obese individuals with perceived psychological stress symptoms at the onset of the study. They were divided into two groups: one group to undergo a psychological lifestyle intervention (60 individuals) and a control group (64 individuals). Both groups managed to lose weight, but reduced stress and improved psychological well-being were reported by the intervention group in particular. Using metabolomics techniques, the researchers performed an extensive analysis of fasting metabolites in all study participants at beginning of the study and again nine months later, after the intervention had ended. Stress and psychological well-being were assessed by surveys and heart rate variability measurements.

Changes in the plasma levels of many phosphatidylcholines were associated with improved psychological well-being, and to some degree also with weight loss. Reduced stress and weight loss were associated with lower levels of certain lysophosphatidylcholines, and with higher levels of some plasmalogens. Obesity and the inflammatory marker interleukin-1 receptor antagonist, on the other hand, were inversely associated with these levels. The researchers also discovered previously unknown lipids that correlated with stress levels.

The observed associations of psychological well-being and weight loss with changes in the plasma lipid profile suggest that the lipids in question play a role in molecular-level mechanisms that interlink psychological and metabolic health.
-end-
For further information, please contact:

Research Director, Kati Hanhineva, University of Eastern Finland, tel. +358403552364, kati.hanhineva (a) uef.fi

Professor Marjukka Kolehmainen, University of Eastern Finland, tel. +358403553617, marjukka.kolehmainen (a) uef.fi

Research article:

Noerman, S., Klåvus, A., Järvelä-Reijonen, E., Karhunen, L., Auriola, S., Korpela, R., Lappalainen, R., Kujala, U.M., Puttonen, S., Kolehmainen, M. & Hanhineva, K. Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms. Sci Rep 10, 2143 (2020). https://doi.org/10.1038/s41598-020-59051-x

University of Eastern Finland

Related Obesity Articles:

Changing the debate around obesity
The UK's National Health Service (NHS) needs to do more to address the ingrained stigma and discrimination faced by people with obesity, says a leading health psychologist.
Study links longer exposure to obesity and earlier development of obesity to increased risk of type 2 diabetes
Cumulative exposure to obesity could be at least as important as actually being obese in terms of risk of developing type 2 diabetes (T2D), concludes new research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).
How much do obesity and addictions overlap?
A large analysis of personality studies has found that people with obesity behave somewhat like people with addictions to alcohol or drugs.
Should obesity be recognized as a disease?
With obesity now affecting almost a third (29%) of the population in England, and expected to rise to 35% by 2030, should we now recognize it as a disease?
Is obesity associated with risk of pediatric MS?
A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.
Women with obesity prior to conception are more likely to have children with obesity
A systematic review and meta-analysis identified significantly increased odds of child obesity when mothers have obesity before conception, according to a study published June 11, 2019 in the open-access journal PLOS Medicine by Nicola Heslehurst of Newcastle University in the UK, and colleagues.
Obesity medicine association announces major updates to its adult obesity algorithm
The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity.
Systematic review shows risk of a child developing overweight or obesity is more than trebled by maternal obesity prior to pregnancy
New research presented at this year's European Congress on Obesity (ECO) in Glasgow, Scotland (April 28- May 1) reveals that the risk of a child becoming overweight or obese is more than trebled by maternal obesity prior to getting pregnant.
Eating later in the day may be associated with obesity
Eating later in the day may contribute to weight gain, according to a new study to be presented Saturday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.
How obesity affects vitamin D metabolism
A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.
More Obesity News and Obesity Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Our Relationship With Water
We need water to live. But with rising seas and so many lacking clean water – water is in crisis and so are we. This hour, TED speakers explore ideas around restoring our relationship with water. Guests on the show include legal scholar Kelsey Leonard, artist LaToya Ruby Frazier, and community organizer Colette Pichon Battle.
Now Playing: Science for the People

#569 Facing Fear
What do you fear? I mean really fear? Well, ok, maybe right now that's tough. We're living in a new age and definition of fear. But what do we do about it? Eva Holland has faced her fears, including trauma and phobia. She lived to tell the tale and write a book: "Nerve: Adventures in the Science of Fear".
Now Playing: Radiolab

Uncounted
First things first: our very own Latif Nasser has an exciting new show on Netflix. He talks to Jad about the hidden forces of the world that connect us all. Then, with an eye on the upcoming election, we take a look back: at two pieces from More Perfect Season 3 about Constitutional amendments that determine who gets to vote. Former Radiolab producer Julia Longoria takes us to Washington, D.C. The capital is at the heart of our democracy, but it's not a state, and it wasn't until the 23rd Amendment that its people got the right to vote for president. But that still left DC without full representation in Congress; D.C. sends a "non-voting delegate" to the House. Julia profiles that delegate, Congresswoman Eleanor Holmes Norton, and her unique approach to fighting for power in a virtually powerless role. Second, Radiolab producer Sarah Qari looks at a current fight to lower the US voting age to 16 that harkens back to the fight for the 26th Amendment in the 1960s. Eighteen-year-olds at the time argued that if they were old enough to be drafted to fight in the War, they were old enough to have a voice in our democracy. But what about today, when even younger Americans are finding themselves at the center of national political debates? Does it mean we should lower the voting age even further? This episode was reported and produced by Julia Longoria and Sarah Qari. Check out Latif Nasser's new Netflix show Connected here. Support Radiolab today at Radiolab.org/donate.