Nav: Home

Targeting pathway may reduce cocaine's cardiovascular harms

February 26, 2018

DALLAS, Feb. 26, 2018 - Scientists have discovered a potential new pathway to treat the harmful effect of cocaine on the cardiovascular system, according to new research in the American Heart Association's journal Hypertension.

Researchers found that excess levels of reactive oxygen species (ROS), molecules known to be found in the aortas of hypertensive animals and humans, are also involved in cocaine-related cardiovascular disease. Reactive oxygen species is a type of unstable molecule that contains oxygen and that easily reacts with other molecules in a cell. A buildup of reactive oxygen species in cells may cause damage to DNA, RNA and proteins and may cause cell death.

The team determined that cocaine activates the molecule microRNA (miR)-30c-5p, increasing ROS levels in the cardiovascular system. But, blocking activation of miR-30c-5p dramatically reduced cocaine-induced cardiovascular impacts.

"The biggest surprise to us was that the modulation of a single miRNA-mRNA pathway could have such a profound effect on cardiovascular function," says Chunming Dong, M.D., study senior author and professor of medicine at University of Miami School of Medicine. "This also suggests that targeting this one pathway may have significant therapeutic benefit, which is an exciting possibility."

In the study, mice injected with cocaine had high blood pressure, stiff blood vessels and excess levels of ROS -- all indications of cardiovascular disease. Cocaine exposure also increased levels of the miR-30c-5p molecule in the mice. When the researchers treated the mice to block the increase in miR-30c-5p, the mice did not show high blood pressure, stiffer blood vessels or elevated ROS levels when given cocaine.

This study is the first to identify the role of miR-30c-5p in cocaine-related cardiovascular disease, Dong says. While the results are promising, the study has limitations as it was conducted in mice, Dong notes. The team plans to test the findings to see if they are observed in patients to determine the viability of this targeted pathway.
-end-
Co-authors are Wei Zhu, Ph.D.; Huilan Wang, Ph.D.; Jianqin Wei, M.D.; Gregory C. Sartor, Ph.D.; Michelle Meiqi Bao; Clay T. Pierce; Claes R. Wahlestedt, M.D., Ph.D.; and Derek M. Dykxhoorn, Ph.D. Author disclosures are on the manuscript.

A seed grant from the Miami Heart Research Institute supported this study.

Additional Resources:
  • After February 26, view the manuscript and editorial online.
  • Follow AHA/ASA news on Twitter @HeartNews
  • For the updates and new science from the Hypertension journal follow @HyperAHA
Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at http://www.heart.org/corporatefunding.

About the American Heart Association

The American Heart Association is devoted to saving people from heart disease and stroke - the two leading causes of death in the world. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat these diseases. The Dallas-based association is the nation's oldest and largest voluntary organization dedicated to fighting heart disease and stroke. To learn more or to get involved, call 1.800.AHA.USA1, visit heart.org or call any of our offices around the country. Follow us on Facebook and Twitter.

American Heart Association

Related Cardiovascular Disease Articles:

A talk with your GP may prevent cardiovascular disease
Having a general practitioner (GP) who is trained in motivational interviewing may reduce your risk of getting cardiovascular disease.
Dilemma of COVID-19, aging and cardiovascular disease
Whether individuals should continue to take angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the context of coronavirus disease 2019 (COVID-19) is discussed in this article.
Air pollution linked to dementia and cardiovascular disease
People continuously exposed to air pollution are at increased risk of dementia, especially if they also suffer from cardiovascular diseases, according to a study at Karolinska Institutet in Sweden published in the journal JAMA Neurology.
New insights into the effect of aging on cardiovascular disease
Aging adults are more likely to have - and die from - cardiovascular disease than their younger counterparts.
Premature death from cardiovascular disease
National data were used to examine changes from 2000 to 2015 in premature death (ages 25 to 64) from cardiovascular disease in the United States.
Ultrasound: The potential power for cardiovascular disease therapy
In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp.
Despite the ACA, millions of Americans with cardiovascular disease still can't get care
Cardiovascular disease (CVD) is the leading cause of death for Americans, yet millions with CVD or cardiovascular risk factors (CVRF) still can't access the care they need, even years after the implementation of the Affordable Care Act (ACA).
Excess weight and body fat cause cardiovascular disease
In the first Mendelian randomization study to look at this, researchers have found evidence that excess weight and body fat cause a range of heart and blood vessel diseases (rather than just being associated with it).
Enzyme may indicate predisposition to cardiovascular disease
Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1's specific interactions in cancer.
Cardiovascular disease in China
This study analyzed data from the Global Burden of Disease Study to look at the rate of cardiovascular disease (CVD) in China along with death and disability from CVD from 1990 to 2016.
More Cardiovascular Disease News and Cardiovascular Disease Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.