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Chemoselective acetalization by a bifuncional cerium phosphate catalyst

February 27, 2017

Acid-base bifunctional catalysts exhibit wide applicability for atom-efficient functional group transformation, tandem reactions, and asymmetric synthesis. In heterogeneous catalysis, the acid-base properties of metal-oxide-based materials have been extensively studied. Nevertheless, it is difficult to construct uniform acid-base sites with controlled electrical and structural properties, which in turn restrains the fine-tuning and reactivity of catalysts. Although oxide surfaces can be readily modified with organic acids or bases, organic functional groups are susceptible to oxidation or thermal degradation, limiting the utility of such catalysts. Thus, it is imperative to design novel high-performance inorganic heterogeneous acid-base catalysts, especially for the manufacture of high value-added products from renewable biomass as a sustainable feedstock.

In this regard, a team of scientists led by Michikazu Hara (Tokyo Institute of Technology) has reported the highly chemoselective acetalization of biomass-derived 5-hydroxymethylfurfural (HMF) with alcohols using a monoclinic CePO4. CePO4, corresponding to rare earth (RE) orthophosphates, are expected to be suitable bifunctional acid-base catalysts, where the synergistic promotion of electrophilicity and nucleophilicity in reactive partners could be achieved.

Mechanistic studies indicated that CePO4 most probably serves as a bifunctional catalyst via the interaction of uniform Lewis acid and weak base sites with HMF and alcohol molecules, respectively, leading to high catalytic performance. Activation of HMF and methanol by CePO4 facilitates the nucleophilic attack of OH in methanol on the carbon atom of C=O, affording the hemiacetal derivative. Next, the reaction between the derivative and methanol by the assistance of CePO4 leads to the acetal. The effectiveness of the bifunctional properties of CePO4 was evidenced by the wide applicability to various acetals including industrially important solketal.

This study discusses a promising strategy employing highly efficient heterogeneous catalysts via the non-dissociative activation of electrophiles and nucleophiles under extremely mild conditions.

Tokyo Institute of Technology

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