Nav: Home

Aggression disorder linked to greater risk of substance abuse

February 28, 2017

People with intermittent explosive disorder (IED)--a condition marked by frequent physical or verbal outbursts--are at five times greater risk for abusing substances such as alcohol, tobacco and marijuana than those who don't display frequent aggressive behavior, according to a new study by researchers from the University of Chicago.

In the study, published Feb. 28, 2017 in the Journal of Clinical Psychiatry, Emil Coccaro, MD, and colleagues analyzed data from more than 9,200 subjects in the National Comorbidity Survey, a national survey of mental health in the United States. They found that as the severity of aggressive behavior increased, so did levels of daily and weekly substance use. The findings suggest that a history of frequent, aggressive behavior is a risk factor for later substance abuse, and effective treatment of aggression could delay or even prevent substance abuse in young people.

IED affects as many as 16 million Americans, more than bipolar disorder and schizophrenia combined. It is often first diagnosed in adolescents, some of whom are as young as 11, years before substance abuse problems usually develop. IED runs in families and is thought to have a significant genetic component, although Coccaro said people tend to treat it as a social-behavioral issue instead of as a true neurobiological disorder.

"People don't see this as a medical problem. They think of it as simply bad behavior they have developed over the course of their lives, but it isn't. It has significant biology and neuroscience behind it," said Coccaro, who is the Ellen C. Manning Professor of Psychiatry and Behavioral Neuroscience at UChicago.

Previous research has implied that aggressive behavior in IED is due to the presence of other psychiatric disorders, such as anxiety or depression. But the new UChicago study found no such relationship. While substance abuse, like excessive drinking, can clearly make aggressive behavior worse, the onset of IED almost always precedes the development of chronic substance abuse. Coccaro and his team found that IED preceded substance abuse in 92.5 percent of the cases where subjects developed both disorders.

Coccaro emphasized that early psychological intervention, medication and cognitive therapy are the most effective treatments to prevent, or at least delay, substance abuse problems in adolescents diagnosed with IED.

"What you're really treating is the emotional dysregulation that leads to aggression," Coccaro said. "The earlier you treat this dysregulation, the more likely you are to offset other disorders that come later down the road."
-end-
The study, "Intermittent Explosive Disorder and Substance Use Disorder: Analysis of the National Comorbidity Survey Replication Sample," was supported by the National Institute of Mental Health. Additional authors include Jennifer Fanning, PhD, and Royce Lee, MD, both from the University of Chicago.

About the University of Chicago Medicine

The University of Chicago Medicine & Biological Sciences is one of the nation's leading academic medical institutions. It comprises the Pritzker School of Medicine, a top 10 medical school in the nation; the University of Chicago Biomedical Sciences Division; and the University of Chicago Medical Center, which recently opened the Center for Care and Discovery, a $700 million specialty medical facility. Twelve Nobel Prize winners in physiology or medicine have been affiliated with the University of Chicago Medicine.

Visit our research blog at sciencelife.uchospitals.edu and our newsroom at uchospitals.edu/news.

Twitter @UChicagoMed, @ScienceLife
Facebook.com/UChicagoMed

University of Chicago Medical Center

Related Mental Health Articles:

Food insecurity can affect your mental health
Food insecurity (FI) affects nearly 795 million people worldwide. Although a complex phenomenon encompassing food availability, affordability, utilization, and even the social norms that define acceptable ways to acquire food, FI can affect people's health beyond its impact on nutrition.
Climate change's toll on mental health
When people think about climate change, they probably think first about its effects on the environment, and possibly on their physical health.
Quantifying nature's mental health benefits
The BioScience Talks podcast features discussions of topical issues related to the biological sciences.
Sexism may be harmful to men's mental health
Men who see themselves as playboys or as having power over women are more likely to have psychological problems than men who conform less to traditionally masculine norms, according to research published by the American Psychological Association.
Mental health matters
UCSB researchers study the effectiveness of an innovative program designed to help youth learn about mental health.
Could mental math boost emotional health?
Engaging the brain's dorsolateral prefrontal cortex (DL-PFC) while doing mental math may be connected with better emotional health, according to Duke researchers.
Program will train mental health providers, improve health care in rural Missouri
A new graduate education program at the University of Missouri has received nearly $700,000 from the Health Resources and Services Administration in the US Department of Health and Human Services to train psychology doctoral candidates in integrated, primary health care settings, in an effort to improve health care for underserved populations with mental health and physical disorders.
Loss of employer-based health insurance in early retirement affects mental, physical health
The loss of private health insurance from an employer can lead to poorer mental and physical health as older adults transition to early retirement, according to a study by Georgia State University.
Ocean views linked to better mental health
Here's another reason to start saving for that beach house: new research suggests that residents with a view of the water are less stressed.
New study shows electronic health records often capture incomplete mental health data
This study compares information available in a typical electronic health record (EHR) with data from insurance claims, focusing on diagnoses, visits, and hospital care for depression and bipolar disorder.

Related Mental Health Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Changing The World
What does it take to change the world for the better? This hour, TED speakers explore ideas on activism—what motivates it, why it matters, and how each of us can make a difference. Guests include civil rights activist Ruby Sales, labor leader and civil rights activist Dolores Huerta, author Jeremy Heimans, "craftivist" Sarah Corbett, and designer and futurist Angela Oguntala.
Now Playing: Science for the People

#520 A Closer Look at Objectivism
This week we broach the topic of Objectivism. We'll be speaking with Keith Lockitch, senior fellow at the Ayn Rand Institute, about the philosophy of Objectivism as it's taught through Ayn Rand's writings. Then we'll speak with Denise Cummins, cognitive scientist, author and fellow at the Association for Psychological Science, about the impact of Objectivist ideology on society. Related links: This is what happens when you take Ayn Rand seriously Another Critic Who Doesn’t Care What Rand Thought or Why She Thought It, Only That She’s Wrong Quote is from "A Companion to Ayn Rand"