Nav: Home

Neutrophils 'vacuum' microbes away from the brain

March 01, 2016

Researchers from the University of Maryland, College Park, and Nanjing Medical University, China, have discovered a new way that white blood cells (neutrophils) defend our brains from infection--they move the microbes from our brains' blood vessels or vasculature so they can be disposed elsewhere instead of just killing them at the site of infection. The final version of the report appears in the March 2016 issue of the Journal of Leukocyte Biology.

"We hope our study opens a new field by using in vivo imaging to investigate how white blood cells interact with microbes in the brain, providing the scientific basis for targeting white blood cells as preventive and therapeutic interventions in brain infections," said Meiqing Shi, D.V.M., Ph.D., a researcher involved in the work from the Division of Immunology, Virginia-Maryland Regional College of Veterinary Medicine at the University of Maryland in College Park, Maryland.

To make their discovery, the University of Maryland and Nanjing Medical University scientists used a form of microscopy, known as intravital microscopy, to visualize in mice the dynamic interactions of neutrophils with C. neoformans arrested in the brain microvasculature. This process enabled the observance of events in real time in living animals. They found that a therapeutic strategy aimed at enhancing the accumulation of neutrophils could help prevent cryptococcal meningoencephalitis.

"New technologies, including the ability to microscopically visualize and watch the behavior of germs and immune cells in living tissues, are revolutionizing our understanding of infections and other diseases," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "These new studies that demonstrate the ability to neutrophils to move dangerous germs away from the brain makes us rethink the coordination in the immune response since these cells were previously thought to simply be soldiers killing germs wherever they found them."
-end-
The Journal of Leukocyte Biology publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.

Details: Mingshun Zhang, Donglei Sun, Gongguan Liu, Hui Wu, Hong Zhou, and Meiqing Shi. Real-time in vivo imaging reveals the ability of neutrophils to remove Cryptococcus neoformans directly from the brain vasculature. J. Leukoc. Biol. 99:467-473; doi:10.1189/jlb.4AB0715-281R ; http://www.jleukbio.org/content/99/3/467.abstract

Early Online Version: October 1, 2015. Final Version: March 1, 2016,

Federation of American Societies for Experimental Biology

Related Blood Vessels Articles:

Flexible and biodegradable electronic blood vessels
Researchers in China and Switzerland have developed electronic blood vessels that can be actively tuned to address subtle changes in the body after implantation.
Lumpy proteins stiffen blood vessels of the brain
Deposits of a protein called ''Medin'', which manifest in virtually all older adults, reduce the elasticity of blood vessels during aging and hence may be a risk factor for vascular dementia.
Cancer cells take over blood vessels to spread
In laboratory studies, Johns Hopkins Kimmel Cancer Center and Johns Hopkins University researchers observed a key step in how cancer cells may spread from a primary tumor to a distant site within the body, a process known as metastasis.
Novel function of platelets in tumor blood vessels found
Scientists at Uppsala University have discovered a hitherto unknown function of blood platelets in cancer.
Blood vessels can make you fat, and yet fit
IBS scientists have reported Angiopoietin-2 (Angpt2) as a key driver that inhibits the accumulation of potbellies by enabling the proper transport of fatty acid into general circulation in blood vessels, thus preventing insulin resistance.
Brothers in arms: The brain and its blood vessels
The brain and its surrounding blood vessels exist in a close relationship.
Feeling the pressure: How blood vessels sense their environment
Researchers from the University of Tsukuba discovered that Thbs1 is a key extracellular mediator of mechanotransduction upon mechanical stress.
Human textiles to repair blood vessels
As the leading cause of mortality worldwide, cardiovascular diseases claim over 17 million lives each year, according to World Health Organization estimates.
How high levels of blood fat cause inflammation and damage kidneys and blood vessels
Viral and bacterial infections are not the only causes of inflammation of body tissue.
3D printing, bioinks create implantable blood vessels
A biomimetic blood vessel was fabricated using a modified 3D cell printing technique and bioinks.
More Blood Vessels News and Blood Vessels Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.