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New formula can predict professional football players' long-term concussion damages

March 01, 2016

LOS ANGELES - Amid the heightened awareness of concussion-related brain damage among professional football players, a new study reports that researchers can predict cognitive outcomes long after the players have retired by reviewing the players' concussion histories, game-related data and their overall mental abilities.

Researchers studied the severity and frequency of game-related concussions among 40 former professional football players, many of whom had suffered cognitive deficits. The researchers combined this data with the estimates of each player's cognitive reserve, a mechanism which helps protect the brain from injury.

Cognitive reserve is developed through mentally enriching experiences, such as education and reading. The researchers concluded that a unique combination of the harmful and the protective factors can predict cognitive outcomes in players who had suffered concussions during their football careers and have been retired from American professional football for an average of 20 years.

"The most important factor in determining the potential cognitive deficits from sports-related concussions was the football players' cognitive reserve" said Matthew J. Wright, PhD, an LA BioMed lead researcher and lead author of the paper published online in the Journal of Clinical and Experimental Psychology. "We also found that post-traumatic amnesia after a concussion was a more significant predictor of later cognitive deficits than the loss of consciousness."

The research was conducted at LA BioMed, the John Wayne Cancer Institute and the University of North Carolina at Chapel Hill. To determine cognitive reserve, the researchers utilized test, questionnaire and interview data. The researchers also surveyed other studies, which have found cognitive reserve is protective in other forms of brain injury and disease, including Alzheimer's disease.

The study's findings are significant because, after motor vehicle accidents, sports-related injuries are the second-most common cause of traumatic brain injuries. Sports-related injuries account for as many as 3.8 million traumatic brain injuries per year in the U.S., according to researchers. Young men, aged 10-19 years, tend to have the highest rates of sports concussions, and 5% to 10% of high school and college American football players are at risk of suffering a concussion each year.

"While further study is needed, our findings open the door to the possibility that professional football could use individual indices to predict the potential for long-term cognitive losses in determining when, or if, a player should return to the field after suffering a concussion," Dr. Wright said.
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Also participating in the research were Ellen Woo, J. Brandon Birath, Craig A. Siders, Daniel F. Kelly, Christina Wang, Ronald Swerdloff, Elizabeth Romero, Claudia Kernan, Robert C. Cantu and Kevin Guskiewicz. Funding was provided by the National Operating Committee on Standards for Athletic Equipment and the National Center for Research Resources, USA (Grant No. M01 RR 19975).

About LA BioMed

Founded in 1952, LA BioMed is one of the country's leading nonprofit independent biomedical research institutes. It has approximately 100 principal researchers conducting studies into improved treatments and therapies for cancer, inherited diseases, infectious diseases, illnesses caused by environmental factors and more. It also educates young scientists and provides community services, including prenatal counseling and childhood nutrition programs. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA and located on the campus of Harbor-UCLA Medical Center. For more information, please visit http://www.LABioMed.org

LA BioMed

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