Nav: Home

Study examines prevalence of rheumatic heart disease in developing country

March 02, 2016

Thomas Pilgrim, M.D., of Bern University Hospital, Bern, Switzerland, and colleagues conducted a study to determine the prevalence and incidence of clinically silent and manifest rheumatic heart disease in Eastern Nepal. The study was published online by JAMA Cardiology.

Three in 4 children grow up in parts of the world where rheumatic heart disease (RHD) is endemic. Nearly eradicated in high-income countries, RHD ranks among the important noncommunicable diseases in low- and middle­ income countries. It is a sentinel of social inequality and a physical manifestation of poverty and continues to be a substantial health care challenge in less privileged regions of the world. This study included 5,178 children, 5 to 15 years of age, from Eastern Nepal. A focused medical history was followed by a brief physical examination. Cardiac auscultation (listening to the heart with a stethoscope) and transthoracic echocardiography were performed by 2 independent physicians.

The prevalence of borderline or definite rheumatic heart disease was 10.2 per 1,000 children and increased with advancing age from 5.5 per 1,000 children 5 years of age to 16.0 in children 15 years of age, whereas the average incidence remained stable at 1.1 per 1,000 children per year. Children with rheumatic heart disease were older than children without rheumatic heart disease and more often female. Silent disease (n = 44) was 5 times more common than manifest disease (n = 9).

"Early detection of silent disease may help prevent progression to severe valvular damage," the authors write.
-end-
(JAMA Cardiology. Published online March 2, 2016; doi:10.1001/jamacardio.2015.0292. This study is available pre-embargo at the For The Media website.)

Editor's Note: The study was funded by research grants from the UBS Optimus Foundation and the Foundation Coeur de la Tour from Switzerland. All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Note: An accompanying commentary, "Screening for Rheumatic Heart Disease in Eastern Nepal," by Bongani M. Mayosi, D.Phil., F.C.P.(S.A.), of Groote Schuur Hospital and University of Cape Town, South Africa, is available pre-embargo at the For The Media website.

The JAMA Network Journals

Related Children Articles:

Do children inherently want to help others?
A new special section of the journal Child Development includes a collection of ten empirical articles and one theoretical article focusing on the predictors, outcomes, and mechanisms related to children's motivations for prosocial actions, such as helping and sharing.
Children need conventional CPR; black and Hispanic children more likely to get Hands-Only
While compressions-only or Hands-Only CPR is as good as conventional CPR for adults, children benefit more from the conventional approach that includes rescue breaths.
Cohen Children's Medical Center study: Children on autism spectrum more likely to wander, disappear
A new study by researchers at Cohen Children's Medical Center of New York suggests that more than one-quarter million school-age children with autism spectrum disorder or other developmental disorders wander away from adult supervision each year.
The importance of children at play
Research highlights positive strengths in developmental learning for Latino children in low-income households based on their interactive play skills.
Racial disparities in pain children of children with appendicitis in EDs
Black children were less likely to receive any pain medication for moderate pain and less likely to receive opioids for severe pain than white children in a study of racial disparities in the pain management of children with appendicitis in emergency departments, according to an article published online by JAMA Pediatrics.
UofL offers vaccine trial for children with relapsed tumors at Kosair Children's Hospital
Children with relapsed tumors and their parents are finding hope in a Phase I research study led by Kenneth G.
Dana-Farber/Boston Children's opens immunotherapy trial for children with leukemia
Dana-Farber/Boston Children's Cancer and Blood Disorders Center has joined a clinical trial of immunotherapy for children with relapsed or treatment-resistant acute lymphoblastic leukemia (ALL).
Children less likely to come to the rescue when others are available
Children as young as 5 years old are less likely to help a person in need when other children are present and available to help, according to new research published in Psychological Science, a journal of the Association for Psychological Science.
IPT for children with anaemia
Researchers from Tanzania and South Africa, who are part of the Cochrane Infectious Disease Group, hosted at LSTM, have conducted an independent review to assess the effect of intermittent preventive antimalarial treatment for children with anaemia living in malaria endemic regions.
Safety first, children
Children are experts at getting into danger. So, how can parents help prevent the consequences?

Related Children Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Changing The World
What does it take to change the world for the better? This hour, TED speakers explore ideas on activism—what motivates it, why it matters, and how each of us can make a difference. Guests include civil rights activist Ruby Sales, labor leader and civil rights activist Dolores Huerta, author Jeremy Heimans, "craftivist" Sarah Corbett, and designer and futurist Angela Oguntala.
Now Playing: Science for the People

#521 The Curious Life of Krill
Krill may be one of the most abundant forms of life on our planet... but it turns out we don't know that much about them. For a create that underpins a massive ocean ecosystem and lives in our oceans in massive numbers, they're surprisingly difficult to study. We sit down and shine some light on these underappreciated crustaceans with Stephen Nicol, Adjunct Professor at the University of Tasmania, Scientific Advisor to the Association of Responsible Krill Harvesting Companies, and author of the book "The Curious Life of Krill: A Conservation Story from the Bottom of the World".