Nav: Home

Thirdhand smoke linked to type 2 diabetes

March 02, 2016

RIVERSIDE, Calif. - Thirdhand smoke (THS) results when exhaled smoke gets on surfaces - clothing, hair, homes and cars. THS has been shown, in mice, to damage the liver and lungs, complicate wound-healing and cause hyperactivity. Add to this list now type 2 diabetes, the most common form of the disease.

Research published today in PLOS ONE by a team led by scientists at the University of California, Riverside shows, in mice, that THS exposure causes insulin resistance, a precursor to type 2 diabetes.

Video

"If confirmed in humans, our study could greatly impact how people view exposure to environmental tobacco toxins," said Manuela Martins-Green, a professor of cell biology and neuroscience at UC Riverside and the lead author of the study. "Children and the elderly are especially vulnerable to THS and its impact on health. Because infants frequently crawl on carpets and touch objects exposed to exhaled smoke, they are at high risk for THS exposure. The elderly are at high risk simply because older organs are more susceptible to disease."

Martins-Green explained that THS consists of tobacco smoke toxins that linger on surfaces and in dust after tobacco has been smoked.

"This includes toxins that become increasingly toxic with age and are re-emitted into the air or react with other chemicals in the environment to produce new pollutants," she said. "Some of these pollutants are carcinogenic."

Her research team found that cellular oxidative stress (arising because of reactive oxygen species) increases in mice exposed to THS, damaging proteins, fats and DNA, and leading to hyperglycemia (excess glucose in the blood stream) and insulinemia (excess insulin in the blood) - a condition also called insulin resistance. When the THS-exposed mice in her lab were treated with antioxidants, the oxidative stress, the molecular damage and the insulin resistance reversed, confirming that THS exposure increased oxidative stress.

"Dr. Martins-Green has a unique animal model for human exposure to THS, especially in small children. This mechanistic study gives us more evidence about the connection between exposure to THS and human health," said Anwer Mujeeb, a biomedical and environmental sciences program officer at the Tobacco-Related Disease Research Program (TRDRP), which funded the study.

The pancreas makes insulin in the body. This hormone lets cells turn sugar - or glucose - from the food we eat into energy. To use and store blood glucose, the pancreas releases more insulin with each meal we eat. In type 1 diabetes, the pancreas no longer makes insulin. Patients are therefore given insulin to boost levels in the body. In type 2 diabetes, the pancreas makes insulin, but cells are not able to respond to it.

"In type 2 diabetes, glucose does not enter the cells and increased levels of insulin, resulting from an overburdened pancreas, do nothing to facilitate glucose entry into cells for producing energy," Martins-Green said. "This is what we saw in 49 percent of the mice we exposed to THS in the lab."

In the United States, nearly 88 million nonsmokers, ages three and older, live in homes where they are exposed to THS as well as secondhand smoke (smoke exhaled by a smoker). As a result of this exposure children have significant blood levels of carcinogens that result when nicotine deposited on the surfaces reacts with nitrous oxide in the environment. THS remains in houses, apartments and hotel rooms even after smokers move out.

"To rid the house of THS, you have to strip the home of everything - furniture, appliances, paint, clothes, ducts, ventilation - that could have THS," Martins-Green said. "It would be more effective to simply move. Yes, there are cleaners we can use, but that would mean exposure to other strong chemicals."

Little is known about the specific health implications of human exposure to THS. The current study, and studies like it that use animal models, could contribute to determining human health risks and developing policies leading to a reduction in both exposure to THS and disease.

To do their experiments, Martins-Green and her team first exposed cages (used for housing the mice) to secondhand smoke using a smoking machine. This smoke landed and accumulated on materials (commonly found in homes) in the cages, and turned into THS. Mice were then introduced into the cages. A control group of mice was not exposed to any THS. The THS-exposed mice were either fed a standard chow diet or a "western diet" - a modified chow diet similar to a high-fat diet people eat.

The THS-exposed mice fed with the western diet showed increased oxidative stress, developed more severe insulin resistance, and gained less weight than the control group of mice, perhaps explaining why humans exposed to firsthand and secondhand smoke lose weight. While nicotine decreases appetite by affecting the brain and some hormone levels, it results also in increased oxidative stress.

"Our findings have direct implications for humans because tobacco toxins are often present in human habitats," Martins-Green said. "We hope our study will influence public policy towards controlling the exposure of nonsmokers - especially infants, children and the elderly - to THS toxins."

Caused by a combination of lifestyle and genetic factors, type 2 diabetes is typically a chronic disease. Symptoms include frequent urination, increased thirst and hunger, and weight loss. Long-term complications (due to high blood sugar) include heart disease, stroke, eyesight problems, and kidney failure. More common in adults, type 2 diabetes is increasingly affecting children as childhood obesity increases. There is no cure; people with the disease manage the condition by eating well, exercising and maintaining a healthy weight.

TRDRP played no role in the study design, data collection and analysis, or in the preparation of the research paper.

"The TRDRP-funded statewide consortium on THS research is a distinctive effort focusing on unraveling this potential public health issue. It is rewarding to see that research by Dr. Martins-Green is contributing to the body of scientific evidence that may support tobacco-control policies in California," said Bart Aoki, the director of TRDRP.

Martins-Green was joined in the study by graduate students Neema Adhami (first author of the research paper) and Cristina Flores at UCR; and Dr. Shelley R. Starck at UC San Francisco.

Next, her team plans to identify THS-induced biomarkers that correlate with liver damage.

"If a person's urine or blood has THS chemicals and biomarkers of liver damage, one can imagine identifying a number of these markers that can be arranged on, say, a strip or a chip which could be used in the physician's office to indicate liver damage allowing for early diagnosis and potential treatment," Martins-Green said.
-end-
The University of California, Riverside is a doctoral research university, a living laboratory for groundbreaking exploration of issues critical to Inland Southern California, the state and communities around the world. Reflecting California's diverse culture, UCR's enrollment has exceeded 21,000 students. The campus opened a medical school in 2013 and has reached the heart of the Coachella Valley by way of the UCR Palm Desert Center. The campus has an annual statewide economic impact of more than $1 billion. A broadcast studio with fiber cable to the AT&T Hollywood hub is available for live or taped interviews. UCR also has ISDN for radio interviews. To learn more, call (951) UCR-NEWS.

University of California - Riverside

Related Diabetes Articles:

The role of vitamin A in diabetes
There has been no known link between diabetes and vitamin A -- until now.
Can continuous glucose monitoring improve diabetes control in patients with type 1 diabetes who inject insulin
Two studies in the Jan. 24/31 issue of JAMA find that use of a sensor implanted under the skin that continuously monitors glucose levels resulted in improved levels in patients with type 1 diabetes who inject insulin multiple times a day, compared to conventional treatment.
Complications of type 2 diabetes affect quality of life, care can lead to diabetes burnout
T2D Lifestyle, a national survey by Health Union of more than 400 individuals experiencing type 2 diabetes (T2D), reveals that patients not only struggle with commonly understood complications, but also numerous lesser known ones that people do not associate with diabetes.
Type 2 diabetes and obesity -- what do we really know?
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world.
A better way to predict diabetes
An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.
The Lancet Diabetes & Endocrinology: Older Americans with diabetes living longer without disability, US study shows
Older Americans with diabetes born in the 1940s are living longer and with less disability performing day to day tasks than those born 10 years earlier, according to new research published in The Lancet Diabetes & Endocrinology journal.
Reverse your diabetes -- and you can stay diabetes-free long-term
A new study from Newcastle University, UK, has shown that people who reverse their diabetes and then keep their weight down remain free of diabetes.
New cause of diabetes
Although insulin-producing cells are found in the endocrine tissue of the pancreas, a new mouse study suggests that abnormalities in the exocrine tissue could cause cell non-autonomous effects that promotes diabetes-like symptoms.
The Lancet Diabetes & Endocrinology: Reducing sugar content in sugar-sweetened drinks by 40 percent over 5 years could prevent 1.5 million cases of overweight and obesity in the UK and 300,000 cases of diabetes
A new study published in The Lancet Diabetes & Endocrinology journal suggests that reducing sugar content in sugar sweetened drinks (including fruit juices) in the UK by 40 percent over five years, without replacing them with any artificial sweeteners, could prevent 500,000 cases of overweight and 1 million cases of obesity, in turn preventing around 300,000 cases of type 2 diabetes, over two decades.
Breastfeeding lowers risk of type 2 diabetes following gestational diabetes
Women with gestational diabetes who consistently and continuously breastfeed from the time of giving birth are half as likely to develop type 2 diabetes within two years after delivery, according to a study from Kaiser Permanente published today in Annals of Internal Medicine.

Related Diabetes Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Climate Crisis
There's no greater threat to humanity than climate change. What can we do to stop the worst consequences? This hour, TED speakers explore how we can save our planet and whether we can do it in time. Guests include climate activist Greta Thunberg, chemical engineer Jennifer Wilcox, research scientist Sean Davis, food innovator Bruce Friedrich, and psychologist Per Espen Stoknes.
Now Playing: Science for the People

#527 Honey I CRISPR'd the Kids
This week we're coming to you from Awesome Con in Washington, D.C. There, host Bethany Brookshire led a panel of three amazing guests to talk about the promise and perils of CRISPR, and what happens now that CRISPR babies have (maybe?) been born. Featuring science writer Tina Saey, molecular biologist Anne Simon, and bioethicist Alan Regenberg. A Nobel Prize winner argues banning CRISPR babies won’t work Geneticists push for a 5-year global ban on gene-edited babies A CRISPR spin-off causes unintended typos in DNA News of the first gene-edited babies ignited a firestorm The researcher who created CRISPR twins defends...