Nav: Home

Scientists find functioning amyloid in healthy brain

March 02, 2020

Scientists from St Petersburg University worked with their colleagues from the St Petersburg branch of the Vavilov Institute of General Genetics. They conducted experiments on laboratory rats and showed that the FRX1 protein in the brains of young and healthy animals functions in an amyloid form. The previously published reports indicate that this protein controls long term memory and emotions: mice that have the FRX1 gene "off" quickly remember even complex mazes, and animals that have too much of this protein do not suffer from depression even after severe stress. In addition, in humans, a failure in the gene encoding FRX1 is linked to autism and schizophrenia.

'Our findings clearly show that developing a universal remedy that will destroy all amyloids in the brain is totally futile. Instead, we need to look for a cure for each specific pathology. The healthy brain was previously known to store only a few protein hormones in amyloid form. They are stored in secretory granules in the hypophysis, but when the time comes, the secretory granules burst and the proteins function in a normal, monomeric form,' said Alexey Galkin, Professor of the Department of Genetics, Doctor of Biology. 'We have initially proved that the protein can actually function in the brain in amyloid form, both as oligomers and as insoluble aggregates. Also, the amyloid form FRX1 can bind RNA molecules and protect them from degradation.'

The research was conducted by the Research Park of St Petersburg University with equipment provided by the resource centres "Chromas Core Facility" and "The Centre for Molecular and Cell Technologies". The amyloid form of FXR1 protein was discovered by scientists using the amyloid proteome screening method developed by a research team in 2016. Amyloids generally play an important role in many organisms: for example, one of these proteins is found in human pigment cells and affects skin tanning. However, today, scientists are interested in amyloids primarily due to the need to find a cure for neurodegenerative diseases, where these proteins play a key role.
-end-


St. Petersburg State University

Related Brain Articles:

Human brain size gene triggers bigger brain in monkeys
Dresden and Japanese researchers show that a human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.
Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers from the University of Copenhagen have designed a model of an early embryonic brain.
An optical brain-to-brain interface supports information exchange for locomotion control
Chinese researchers established an optical BtBI that supports rapid information transmission for precise locomotion control, thus providing a proof-of-principle demonstration of fast BtBI for real-time behavioral control.
Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.
Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.
Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.
Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.
BRAIN Initiative tool may transform how scientists study brain structure and function
Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions.
Wiring diagram of the brain provides a clearer picture of brain scan data
In a study published today in the journal BRAIN, neuroscientists led by Michael D.
Blue Brain Project releases first-ever digital 3D brain cell atlas
The Blue Brain Cell Atlas is like ''going from hand-drawn maps to Google Earth'' -- providing previously unavailable information on major cell types, numbers and positions in all 737 brain regions.
More Brain News and Brain Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Warped Reality
False information on the internet makes it harder and harder to know what's true, and the consequences have been devastating. This hour, TED speakers explore ideas around technology and deception. Guests include law professor Danielle Citron, journalist Andrew Marantz, and computer scientist Joy Buolamwini.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.