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Screening for heart disease may lead to prevention, better treatments

March 06, 2017

Through computed tomography (CT) images of the heart and other types of imaging, build-up of dangerous coronary plaques--which restrict the flow of blood to the heart--can be detected, even before a person develops symptoms of heart disease. Because of this, there is increasing interest in using these imaging techniques to screen for heart disease. According to a review published today in JACC: Cardiovascular Imaging, a simple CT imaging technique called a coronary artery calcium (CAC) scan--often referred to as a "calcium scan"--may be particularly useful when screening for coronary artery disease.

People are screened for many types of diseases, such as breast, colon and lung cancer, even when no symptoms are present. However, there is currently no consensus among physician groups regarding when to use cardiac imaging to screen for heart disease--even though heart disease is the leading cause of death in the U.S. Instead, a patient is typically assessed using a combination of historical data and a standard blood test to measure serum lipids and blood glucose levels to arrive at a risk score to help determine if they will have heart disease in the future. While these risk scores have been proven to be somewhat useful, increasing data indicates that a CAC scan is far more accurate for this purpose.

Coronary calcium builds up at the site of coronary plaque, so a CAC scan can be effective in detecting even minute amounts of CAC. The scan results are then recorded using a "CAC score," which represents the total amount of CAC in the coronary arteries. The higher the CAC score, the greater the risk for future heart disease.

"The CAC scan can detect heart disease even decades before the symptoms of heart disease may first appear," said the study's lead author, Alan Rozanski, MD, chief academic officer and director of the cardiology fellowship training program for the division of cardiology at Mount Sinai St. Lukes Hospital in New York. "Additionally, using current state-of-the-art scanners, CAC scans are associated with only very low radiation exposure, similar to that of a mammogram, and they are less costly than all other types of imaging. Given these advantages, there is increasing interest in determining whether the use of CAC scanning could lead to earlier and more effective treatment of heart disease."

Research has shown that in approximately 40-60 percent of cases, the first time heart disease is discovered is when a heart attack or death occurs.

"By using imaging for screening, we can detect problems early on, which gives the patient an opportunity to make lifestyle changes to help avoid developing heart disease--such as by improving nutrition, starting to exercise or quitting smoking," Rozanski said. "We believe this will not only help improve and save lives but that it can ultimately contribute to lower health costs since the earlier adoption of positive health habits can reduce patients clinical risk and potentially eliminate the need for more costly interventions later on."

To help understand the best type and methods of imaging to use for screening to prevent cardiac disease and learn more about the clinical outcomes related to screening, the researchers evaluated five clinical trials with 4,615 participants who were not showing signs of heart disease: one trial involved cardiac stress imaging, three involving CAC scanning and one involved non-invasive coronary CT angiography.

Collectively, the trials showed an important hurdle: because modern therapies have markedly reduced the frequencies for developing the most serious consequences of heart disease, such as heart attacks and sudden death, it may be difficult to prove that the use of imaging techniques reduce cardiac death, per se, in clinical trials. Instead, investigators may be increasingly interested to determine if CAC scanning and other screening techniques can improve the overall cardiac risk profile of patients without increasing medical costs. In one of the trials that were reviewed, the EISNER trial, the use of CAC scanning was shown to improve cardiac risk profiles without increasing overall medical costs, but more studies in this area are needed.

"There is now sufficient evidence to support the routine use of CAC scanning for screening in clinical practice" Rozanski said. "Importantly, the CAC score has become one of our most robust predictors of patient risk. Patients are at very low risk when the CAC score is zero and at high risk when the CAC score is highly elevated. Any degree of CAC abnormality, however, even a CAC score of one or above, is sufficient reason for patients to adopt more heart-healthy behaviors."
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The American College of Cardiology is a 52,000-member medical society that is the professional home for the entire cardiovascular care team. The mission of the College is to transform cardiovascular care and to improve heart health. The ACC leads in the formation of health policy, standards and guidelines. The College operates national registries to measure and improve care, offers cardiovascular accreditation to hospitals and institutions, provides professional medical education, disseminates cardiovascular research and bestows credentials upon cardiovascular specialists who meet stringent qualifications. For more, visit acc.org.

The Journal of the American College of Cardiology is the most widely read cardiovascular journal in the world and is the top ranked cardiovascular journal for its scientific impact. JACC is the flagship for a family of journals that publish peer-reviewed research on all aspects of cardiovascular disease. JACC: Cardiovascular Interventions, JACC: Cardiovascular Imaging and JACC: Heart Failure also rank among the top ten cardiovascular journals for impact. JACC: Clinical Electrophysiology and JACC: Basic to Translational Science are the newest journals in the JACC family. Learn more at JACC.org.

American College of Cardiology

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