Nav: Home

Mayo Clinic researchers identify therapy

March 08, 2017

PHOENIX -- Mayo Clinic researchers have found that an experimental drug, LCL161, stimulates the immune system, leading to tumor shrinkage in patients affected by multiple myeloma. The findings are published in Nature Medicine.

Multiple myeloma is a blood cancer that affects plasma cells - white blood cells that normally produce antibodies to fight infection. Rather than produce helpful antibodies, the cancer cells, as they grow, secrete large amounts of a single antibody that accumulate in the body, causing kidney problems and infections.

"The drug, LCL161, was initially developed to promote tumor death," says Marta Chesi, Ph.D., a Mayo Clinic biochemist and lead author of the study of 25 Multiple Myeloma patients. "However, we found that the drug does not kill tumor cells directly. Rather, it makes them more visible to the immune system that recognizes them as foreigner invaders and eliminates them."

Mayo Clinic researchers will conduct a follow-up clinical trial of LCL161 in combination with an inhibitor of immune checkpoints that has been widely used in many cancer treatments to evaluate if LCL161 could represent a potential new treatment option.

"The model for preclinical studies to predict with great accuracy which drugs would work in the clinic was developed a decade ago," says Dr. Chesi. "And it has been instrumental in the prioritization of which experimental therapeutics should be tested in patients with multiple myeloma."

The research highlights the importance of studying the effects of drugs not only on the tumor cells in a culture plate, but also on the interaction of the tumor cells with their own microenvironment. The finding that LCL161 is active against multiple myeloma suggests that similar drugs may have broader clinical activity than previously thought.
-end-
The work of Dr. Chesi and her team reflects Mayo Clinic's focus to bridge basic science discoveries into clinical trials through collaboration, beginning with unmet patient needs.

Study co-authors are:
    * Ilseyar Akhmetzyanova, Albert Einstein College of Medicine
    * Gregory Ahmann, Mayo Clinic
    * Sikander Ailawadhi, M.D., Mayo Clinic
    * Yan Asmann, Ph.D., Mayo Clinic
    * Leif Bergsagel, M.D., Mayo Clinic, David F. and Margaret T. Grohne Professor of Novel Therapeutics for Cancer Research
    * Francis Buadi, M.D., Mayo Clinic
    * Arianna Calcinotto, Ph.D., Mayo Clinic Asher Chanan-Khan, M.D., Mayo Clinic
    * David Dingli, M.D., Ph.D., Mayo Clinic
    * Angela Dispenzieri, M.D., Mayo Clinic, Serene M. and Frances C. Durling Professor
    * Amylou Dueck, Ph.D., Mayo Clinic
    * Rafael Fonseca, M.D., Mayo Clinic, Getz Family Professor of Cancer
    * David Fooksman, Ph.D., Albert Einstein College of Medicine
    * Victoria Garbitt, Mayo Clinic
    * Morie Gertz, M.D., Mayo Clinic, Roland Seidler, Jr., Professor of the Art of Medicine in Honor of Michael D. Brennan, M.D.
    * Niamh Keane, M.B., Ch.B., Mayo Clinic Heidi Kosiorek, Mayo Clinic
    * Shaji Kumar, M.D., Mayo Clinic
    * Martha Lacy, M.D., Mayo Clinic
    * Yi Lin, M.D., Ph.D., Mayo Clinic
    * Kevin Morrison, Mayo Clinic
    * Noweeda Mirza, Ph.D., Mayo Clinic
    * Craig Reeder, M.D., Mayo Clinic
    * Daniel Riggs, Ph.D., Mayo Clinic
    * Meaghen Sharik, Mayo Clinic
    * Keith Stewart, M.D., Ch.B., Mayo Clinic, Vasek and Anna Maria Polak Professor of Cancer Research, Carlson and Nelson Endowed Director, Center for Individualized Medicine


About Mayo Clinic


Mayo Clinic is a nonprofit organization committed to clinical practice, education and research, providing expert, whole-person care to everyone who needs healing. For more information, visit http://www.mayoclinic.org/about-mayo-clinic or http://newsnetwork.mayoclinic.org/.

Mayo Clinic

Related Immune System Articles:

Using the immune system as a defence against cancer
Research published today in the British Journal of Cancer has found that a naturally occurring molecule and a component of the immune system that can successfully target and kill cancer cells, can also encourage immunity against cancer resurgence.
First impressions go a long way in the immune system
An algorithm that predicts the immune response to a pathogen could lead to early diagnosis for such diseases as tuberculosis
Filming how our immune system kill bacteria
To kill bacteria in the blood, our immune system relies on nanomachines that can open deadly holes in their targets.
Putting the break on our immune system's response
Researchers have discovered how a tiny molecule known as miR-132 acts as a 'handbrake' on our immune system -- helping us fight infection.
Decoding the human immune system
For the first time ever, researchers are comprehensively sequencing the human immune system, which is billions of times larger than the human genome.
Masterswitch discovered in body's immune system
Scientists have discovered a critical part of the body's immune system with potentially major implications for the treatment of some of the most devastating diseases affecting humans.
How a fungus can cripple the immune system
An international research team led by Professor Oliver Werz of Friedrich Schiller University, Jena, has now discovered how the fungus knocks out the immune defenses, enabling a potentially fatal fungal infection to develop.
How the immune system protects us against bowel cancer
Researchers from Charité - Universitätsmedizin Berlin have discovered a protective mechanism which is used by the body to protect intestinal stem cells from turning cancerous.
How herpesviruses shape the immune system
DZIF scientists at the Helmholtz Zentrum München have developed an analytic method that can very precisely detect viral infections using immune responses.
The immune system's fountain of youth
Helping the immune system clear away old cells in aging mice helped restore youthful characteristics.
More Immune System News and Immune System Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#538 Nobels and Astrophysics
This week we start with this year's physics Nobel Prize awarded to Jim Peebles, Michel Mayor, and Didier Queloz and finish with a discussion of the Nobel Prizes as a way to award and highlight important science. Are they still relevant? When science breakthroughs are built on the backs of hundreds -- and sometimes thousands -- of people's hard work, how do you pick just three to highlight? Join host Rachelle Saunders and astrophysicist, author, and science communicator Ethan Siegel for their chat about astrophysics and Nobel Prizes.