Nav: Home

Delivery strategies of chemotherapy to the central nervous system

March 09, 2016

The research thoroughly reviews the importance of the blood-brain barrier (BBB) and the blood-tumor barrier (BTB) along with the current status and future perspectives of interesting physical and surgical strategies to circumvent these central nervous system (CNS) barriers in the treatment of malignant brain tumors.

In this paper, the authors particularly focus on assessing the development of a selected number of strategies that enhance the distribution of therapeutic agents to the CNS in the context of neuro-oncology. This review is unique in the sense that it concentrates on surgical and physical delivery methods that are of present-day interest and in current development. The following strategies are discussed in this review: intra-arterial delivery, osmotic BBB disruption, intra-nasal delivery, convection-enhanced delivery, implanted polymers, magnetic microspheres and ultrasound BBB disruption. For each delivery method, un-biased and up to date information on the current technique, preclinical data and available clinical data is provided.

This detailed overview on the topic will raise great interest in the oncology community as it is shown to be a greatly prospering field of research. Finally, the authors also underline the importance of encouraging collaborations to allow greater progress in preclinical and clinical research with the overall goal to find ways to better impact patient outcomes and survival.
-end-


Bentham Science Publishers

Related Central Nervous System Articles:

Zika combats advanced-stage central nervous system tumors in dogs
The viral therapy was tested in three elderly animals with spontaneous brain tumors by a group affiliated with the FAPESP-funded Human Genome and Stem Cell Research Center.
Fewer scars in the central nervous system
Researchers have discovered the influence of the coagulation factor fibrinogen on the damaged brain.
Mayo Clinic discovers a molecular switch for repairing central nervous system disorders
A molecular switch has the ability to turn on a substance in animals that repairs neurological damage in disorders such as multiple sclerosis (MS), Mayo Clinic researchers discovered.
Discovery concerning the nervous system overturns a previous theory
It appears that when our nervous system is developing, only the most viable neurons survive, while immature neurons are weeded out and die.
Nanocapsule reaches cancer that has spread to central nervous system in mice
Researchers developed a drug delivery system that can break through the blood-brain barrier in mice.
Persistent HIV in central nervous system linked to cognitive impairment
Many people with HIV on antiretroviral therapy (ART) have viral genetic material in the cells of their cerebrospinal fluid, and these individuals are more likely to experience memory and concentration problems, according to a NIAID-funded study published in the Journal of Clinical Investigation.
First step to induce self-repair in the central nervous system
Injured axons instruct Schwann cells to build specialized actin spheres to break down and remove axon fragments, thereby starting the regeneration process.
First complete wiring diagram of an animal's nervous system
In a study published online today in Nature, researchers at Albert Einstein College of Medicine describe the first complete wiring diagram of the nervous system of an animal, the roundworm Caenorhabditis elegans, used by scientists worldwide as a model organism.
Scientists unlock new role for nervous system in regeneration
Biologists have developed a computational model of flatworm regeneration to answer an important question in regeneration research - what are the signals that determine the rebuilding of specific anatomical structures?
Microglia, immune cells of the central nervous system, shown to regulate neuroinflammation
A research team at Massachusetts Eye and Ear has shown that microglia, the immune cells of the central nervous system -- including the retina -- serve as 'gatekeepers' of neuroinflammation.
More Central Nervous System News and Central Nervous System Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Processing The Pandemic
Between the pandemic and America's reckoning with racism and police brutality, many of us are anxious, angry, and depressed. This hour, TED Fellow and writer Laurel Braitman helps us process it all.
Now Playing: Science for the People

#568 Poker Face Psychology
Anyone who's seen pop culture depictions of poker might think statistics and math is the only way to get ahead. But no, there's psychology too. Author Maria Konnikova took her Ph.D. in psychology to the poker table, and turned out to be good. So good, she went pro in poker, and learned all about her own biases on the way. We're talking about her new book "The Biggest Bluff: How I Learned to Pay Attention, Master Myself, and Win".
Now Playing: Radiolab

Invisible Allies
As scientists have been scrambling to find new and better ways to treat covid-19, they've come across some unexpected allies. Invisible and primordial, these protectors have been with us all along. And they just might help us to better weather this viral storm. To kick things off, we travel through time from a homeless shelter to a military hospital, pondering the pandemic-fighting power of the sun. And then, we dive deep into the periodic table to look at how a simple element might actually be a microbe's biggest foe. This episode was reported by Simon Adler and Molly Webster, and produced by Annie McEwen and Pat Walters. Support Radiolab today at Radiolab.org/donate.