Study puts drug-eluting stents to test in heart attack patients

March 12, 2006

ATLANTA, GA (March 12, 2006) -- Research presented today at the American College of Cardiology's inaugural Innovation in Intervention: i2 Summit 2006 in Atlanta, Ga., offers new insight into whether medicated stents can prevent late complications in patients with the most serious form of heart attack. Innovation in Intervention: i2 Summit is an annual meeting for practicing cardiovascular interventionalists sponsored by the American College of Cardiology in partnership with the Society for Cardiovascular Angiography and Interventions.

Drug-eluting stents--which slowly release medication into the artery wall--prevent a build-up of scar tissue inside the stent, a complication known as in-stent restenosis. These devices have only been rigorously tested in patients with stable cardiovascular disease. The Randomized Comparison of Paclitaxel Eluting Stent Versus Conventional Stent in ST-segment Elevation Myocardial Infarction (PASSION) study has taken the next step, focusing on patients with the most serious form of heart attack, ST-segment elevation myocardial infarction (STEMI).

"We wanted to know whether a paclitaxel-eluting stent could decrease restenosis and limit repeat coronary interventions in patients with acute STEMI," said Mauritis T. Dirksen, M.D., one of the investigators of the PASSION study. Dr. Dirksen and his colleagues from the Amsterdam Department of Interventional Cardiology, OLVG, The Netherlands, randomly assigned 620 patients with acute STEMI to artery-opening treatment with either a conventional bare-metal stent (the BSX Express2 or Liberté) or a paclitaxel-eluting (BSX Taxus) stent. After one year, they compared the combined rates of death, repeat MI, and repeat catheter-based intervention or bypass surgery on the heart-attack-related artery. A preliminary six-month follow-up showed that the paclitaxel-eluting stent reduced the rate of repeat procedures in or near the stent to just 1 percent, as compared to 3.6 percent with the bare-metal stent. The drug-eluting did not improve other clinical outcomes, however.

Dr. Dirksen will present one-year follow-up results at a Late Breaking Clinical Trials session on Sunday, March 12, at 9:20 a.m. ET and at a press conference on Monday, March 12, at 8 a.m. ET.
-end-
The American College of Cardiology (www.acc.org) represents the majority of board certified cardiovascular physicians in the United States. Its mission is to advocate for quality cardiovascular care through education, research, promotion, development and application of standards and guidelines- and to influence health care policy. ACC.06 and the ACC inaugural i2 Summit, the first-ever meeting for interventional cardiologists, will bring together more than 30,000 cardiologists and cardiovascular specialists to share the newest discoveries in treatment and prevention, while helping the ACC achieve its mission to address and improve issues in cardiovascular medicine.

Innovation in Intervention: i2 Summit is an annual meeting for those practicing coronary and non-coronary interventions. Sponsored by the American College of Cardiology, in partnership with the Society for Cardiovascular Angiography and Interventions and other professional associations, i2 Summit 2006 offers late-breaking interventional clinical trials, peripheral, vascular, coronary and valvular education, live cases from Europe, Asia and the United States, emerging technology / state-of-the-art lectures, expert simulation demonstrations, interactive Laptop Learning and general cardiovascular education at ACC.06, held concurrently with i2 Summit, for a dynamic, complete cardiovascular educational experience. i2 Summit consolidates all clinical, educational, practical and community needs into one event and delivers unsurpassed needs-based learning with true objectivity.

American College of Cardiology

Related Heart Attack Articles from Brightsurf:

Top Science Tip Sheet on heart failure, heart muscle cells, heart attack and atrial fibrillation results
Newly discovered pathway may have potential for treating heart failure - New research model helps predict heart muscle cells' impact on heart function after injury - New mass spectrometry approach generates libraries of glycans in human heart tissue - Understanding heart damage after heart attack and treatment may provide clues for prevention - Understanding atrial fibrillation's effects on heart cells may help find treatments - New research may lead to therapy for heart failure caused by ICI cancer medication

Molecular imaging identifies link between heart and kidney inflammation after heart attack
Whole body positron emission tomography (PET) has, for the first time, illustrated the existence of inter-organ communication between the heart and kidneys via the immune system following acute myocardial infarction.

Muscle protein abundant in the heart plays key role in blood clotting during heart attack
A prevalent heart protein known as cardiac myosin, which is released into the body when a person suffers a heart attack, can cause blood to thicken or clot--worsening damage to heart tissue, a new study shows.

New target identified for repairing the heart after heart attack
An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage.

Heart cells respond to heart attack and increase the chance of survival
The heart of humans and mice does not completely recover after a heart attack.

A simple method to improve heart-attack repair using stem cell-derived heart muscle cells
The heart cannot regenerate muscle after a heart attack, and this can lead to lethal heart failure.

Mount Sinai discovers placental stem cells that can regenerate heart after heart attack
Study identifies new stem cell type that can significantly improve cardiac function.

Fixing a broken heart: Exploring new ways to heal damage after a heart attack
The days immediately following a heart attack are critical for survivors' longevity and long-term healing of tissue.

Heart patch could limit muscle damage in heart attack aftermath
Guided by computer simulations, an international team of researchers has developed an adhesive patch that can provide support for damaged heart tissue, potentially reducing the stretching of heart muscle that's common after a heart attack.

How the heart sends an SOS signal to bone marrow cells after a heart attack
Exosomes are key to the SOS signal that the heart muscle sends out after a heart attack.

Read More: Heart Attack News and Heart Attack Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.