Nav: Home

Lower costs associated with late-preterm steroid therapy, NIH-funded analysis finds

March 12, 2019

WHAT:

An analysis of a previous study has found more evidence to support giving the steroid betamethasone to pregnant women at risk of late-preterm delivery (between 34 and 36 weeks of gestation), according to a network funded by the National Institutes of Health. Hospital stays for infants whose mothers received the drug cost less on average, compared to stays for infants whose mothers did not take the drug. The study appears in JAMA Pediatrics.

Prenatal steroids are a standard treatment for women at risk of giving birth before 34 weeks of pregnancy. The drugs improve survival by helping the fetal lungs to mature. Originally, researchers thought that steroid treatment was not needed for late-preterm infants, but a 2016 randomized trial conducted by the Maternal-Fetal Medicine Units (MFMU) Network, a group of clinical sites funded by NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), suggested that the practice could provide some benefit. That study found that late preterm infants whose mothers received betamethasone during pregnancy had fewer lung complications and less need for respiratory treatments, compared to those whose mothers had not received the drug. Side effects of steroids include sepsis (blood infection), blood clots and bone fracture.

For the current study, MFMU researchers estimated costs for 1,426 mother-infant pairs in the original study based on Medicaid rates and costs for newborn intensive care, hospital stays and outpatient visits. The average cost for the betamethasone group was $4,681, while the cost for those who did not receive the drug was $5,379.
-end-
NIH's National Heart, Lung, and Blood Institute also provided funding for the study.

WHO:

Caroline Signore, M.D., of the NICHD Pregnancy and Perinatology Branch, is available for comment.

ARTICLE:

Gyamfi-Bannerman, C, et al. Cost-effectiveness of antenatal corticosteroid therapy vs no therapy in women at risk of late preterm delivery: a secondary analysis of a randomized clinical trial. JAMA Pediatrics. Doi:10.1001/jamapediatrics.2019.0032

About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD conducts and supports research in the United States and throughout the world on fetal, infant and child development; maternal, child and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visit NICHD's website.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Related Infants Articles:

Premature infants at greater risk of SIDS
Premature infants still have a greater risk compared to full-term babies of dying of SIDS and other sleep-related infant deaths despite recommendations from the American Academy of Pediatrics that hospital NICU's provide more safe infant sleep education to parents before they go home.
Detecting autism in infants before symptoms emerge
According to the results of a new study, a brain scan can detect functional changes in babies as young as six months of age that predicts later diagnosis with autism spectrum disorder (ASD).
Rotavirus vaccination in infants and young children
Rotaviruses (RV) are the commonest cause of diarrhea in infants and young children worldwide.
A mother's voice may help stabilize preterm infants
A recent review of published research indicates that hearing their mother's voice can benefit the health of preterm infants.
Healthy weight gain in infants
With nearly 10 percent of infants considered 'high weight for length,' University of Delaware researcher Jillian Trabulsi wants to help babies achieve a healthy weight starting with their first months of life.
Mothers and infants connect through song
Research from UM Frost School of Music provides insight into the importance of song for infants and mothers.
Infants use prefrontal cortex in learning
A group of 8-month-olds has provided evidence that, contrary to conventional wisdom, the prefrontal cortex contributes to learning during infancy.
Very premature infants: Towards better care
Born too soon, very premature infants are particularly vulnerable and need appropriate care.
Maternal vaccination again influenza associated with protection for infants
How long does the protection from a mother's immunization against influenza during pregnancy last for infants after they are born?
Infants much less likely to get the flu if moms are vaccinated while pregnant
Babies whose moms were vaccinated against the flu while pregnant had a 70 percent reduction in confirmed flu cases compared with infants whose moms weren't immunized, study finds.

Related Infants Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#529 Do You Really Want to Find Out Who's Your Daddy?
At least some of you by now have probably spit into a tube and mailed it off to find out who your closest relatives are, where you might be from, and what terrible diseases might await you. But what exactly did you find out? And what did you give away? In this live panel at Awesome Con we bring in science writer Tina Saey to talk about all her DNA testing, and bioethicist Debra Mathews, to determine whether Tina should have done it at all. Related links: What FamilyTreeDNA sharing genetic data with police means for you Crime solvers embraced...