Nav: Home

Hepatitis B vaccination in preadolescents lowered the disease incidence rate in Catalonia

March 13, 2019

Introducing Hepatitis B vaccine in preadolescents meant a decline in the disease incidence rate by 52 % according to a study in which the University of Barcelona (UB) took part. The study analysed the efficiency and impact of the vaccination program set in Catalonia (Spain) twenty-one years ago. The results show that after introducing the program, the incidence rate in general population went from 2.5 per 100,000 people in 1991 to 1.2 per 100,000 people in 2014.

The study, published in the scientific journal Vaccine, counts on the participation of experts from the Research Group on Epidemiology, Prevention and Control of Communicable Diseases of the UB, the Public Health Agency of Catalonia and the Barcelona Public Health Agency, led by Professor Àngela Domínguez, from the Department of Medicine of the UB and the Epidemiology and Public Health Networking Biomedical Research Centre (CIBERESP, Institute of Health Carlos III).

Hepatitis B is a globally important viral disease due its morbidity, mortality and high chronicity in children. Chronicity increases the risk of cirrhosis and hepatocellular carcinoma, and patients with a chronic disease are permanent transmitters of the virus. In 1991, systematic vaccination for Hepatitis B was introduced in Catalonia in preadolescents. "So far, only risk groups were vaccinated, such as those working in the health sector or haemophiliac and haemodialytic patients. However, this type of vaccination was not enough to reduce the incidence", note the researchers.

An efficient program

Researchers studied retrospectively vaccinated and non-vaccinated cohorts, chosen according to their year of birth, as well as cases of Hepatitis B between 2000 and 2014 that were registered by the Sub-Directorate General for Epidemiological Surveillance and Public Health Emergency Response of the Public Health Agency of Catalonia. During that period, they notified about 388 cases of Hepatitis B infection, 232 in the non-vaccinated cohort and 156 in the vaccinated cohort.

The incidence rate was 4.1 per 100,000 people per year in the non-vaccinated group and 0.03 per 100,000 people per year in the vaccinated group. Therefore, the efficiency of the program was 99.30 % and the associated benefit to estimate the prevented fraction was of 64.56 %. According to the researchers, these results show that "efficiency and impact of the vaccination program for Hepatitis B in preadolescents are high, benefiting the community".

Vaccination in preadolescents was suspended in July 2014, when the first kids who had been vaccinated as children (vaccinated in 2002, aged one) reached preadolescence, so they did not need the vaccine again.
-end-


University of Barcelona

Related Hepatitis Articles:

Hepatitis C increasing among pregnant women
Hepatitis C infections among pregnant women nearly doubled from 2009-2014, likely a consequence of the country's increasing opioid epidemic that is disproportionately affecting rural areas of states including Tennessee and West Virginia.
WHO's Global Hepatitis Report sets baseline to eliminate viral hepatitis by 2030
The World Hepatitis Alliance today welcomes the publication of the first-ever Global Hepatitis Report by the World Health Organization (WHO), which includes new data on the prevalence and global burden of viral hepatitis.
Elimination of viral hepatitis by 2030: What's needed and how do we get there?
This first European Action Plan provides an important driver to aid countries in their fight against viral hepatitis, to which ECDC had the opportunity to contribute directly.
Discovery of new Hepatitis C virus mechanism
Researchers at Osaka University, Japan uncovered the mechanisms that suppress the propagation of the hepatitis C virus with the potential of improving pathological liver conditions.
Is Europe ready to eliminate viral hepatitis?
Currently, Europe records around 57,000 newly diagnosed acute and chronic cases of hepatitis B and C each year.
Why baby boomers need a hepatitis C screening
Hepatitis C affects a disproportionate amount of older Americans, born between 1945 and 1965.
Counterattack of the hepatitis B virus
The hepatitis B virus (HBV) infects liver cells. Drugs are available to treat HBV, but they rarely cure the infection, and so the virus typically returns after the treatment ends.
Hepatitis C tied to increased risk of Parkinson's
The hepatitis C virus may be associated with an increased risk of developing Parkinson's disease, according to a study published in the Dec.
The hepatitis A virus is of animal origin
The hepatitis A virus can trigger acute liver inflammation which generally has a mild course in small children but which can become dangerous in adults.
Modeling the helicase to understand hepatitis C
NS3 is an enzyme specific to the hepatitis C virus.

Related Hepatitis Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#529 Do You Really Want to Find Out Who's Your Daddy?
At least some of you by now have probably spit into a tube and mailed it off to find out who your closest relatives are, where you might be from, and what terrible diseases might await you. But what exactly did you find out? And what did you give away? In this live panel at Awesome Con we bring in science writer Tina Saey to talk about all her DNA testing, and bioethicist Debra Mathews, to determine whether Tina should have done it at all. Related links: What FamilyTreeDNA sharing genetic data with police means for you Crime solvers embraced...