Nav: Home

Scientists have synthesized new molecules with anticancer and antioxidant activity

March 14, 2016

A group of scientists from Moscow universities led by Yan Ivanenkov, the head of Laboratory of Medical Chemistry and Bioinformatics in MIPT, has succeeded in synthesizing a set of novel selenohydantoins with anticancer and antioxidant activity. The corresponding paper has been published in the scientific journal Bioorganic & Medicinal Chemistry.

It was found that synthesized molecules could potentially be used as anticancer agents with good selectivity index. Hydantoin moiety and its derivatives can be found in many drug molecules, including nilutamide, which is used in chemotherapy for prostate cancer, and dantrolene, which helps to relax skeletal muscles and prevent cramps.

Selenohydantoins are derivatives of hydantoins in which one of the oxygen atoms is replaced by selenium. It was found that drug molecules containing selenium possess anticancer activity and can be used as effective antioxidants. Selenium can be found in a number of known drug molecules, such as Ebselen - an antioxidant with a broad spectrum of therapeutic activity.

In the study, the scientists have synthesized novel selenium-containing hydantoin derivatives. The structures of the molecules obtained were confirmed by NMR (Nuclear Magnetic Resonance) spectroscopy, high resolution mass spectrometry, and X-ray analysis. It was found that in the presence of Cu2+ copper cations, a spatial transformation is observed and a stable isomer is formed.

Isomers are molecules with the same atomic composition, but different spatial structure. The interest lies in the fact that the isomers differ in terms of their properties and activity. The scientists used quantum-chemical calculations to explain the mechanism of the transformation they had discovered.

The results of electromechanical studies showed that the synthesized molecules possess antioxidant activity, which means they are able to slow down the process of oxidation. They are also able to bind to receptors that protect the body from oxidation.

"We have examined the effect of selenium on the activity of the synthesized molecules. The next step is to investigate the pharmacological potential of the most active molecules in vivo and in vitro," said Yan Ivanenkov, the head of the Laboratory of Medical Chemistry and Bioinformatics, when commenting on the prospects of the research.

The results of the study highlighted the important role of selenium in the structure of hydantoin derivatives. Structural modification such as this has a significant influence on the spectrum of biological activity and properties of the molecules.
-end-


Moscow Institute of Physics and Technology

Related Selenium Articles:

Vitamin E, selenium supplements did not prevent dementia
Antioxidant supplements vitamin E and selenium -- taken alone or in combination -- did not prevent dementia in asymptomatic older men, according to a study published online by JAMA Neurology.
Selenium deficiency promoted by climate change
As a result of climate change, concentrations of the trace element selenium in soils are likely to decrease.
Coal ash selenium found in fish in N.C. lakes
A new Duke study has found high levels of selenium in the tissues of fish in North Carolina lakes that receive coal ash effluents from power plants.
Vitamin E and selenium don't prevent polyps that can lead to colorectal cancer
A SWOG review of ancillary SELECT results definitively shows that two antioxidants, vitamin E and selenium, don't prevent colorectal adenomas -- polyps that are the premalignant precursors to most colorectal cancers.
UA Cancer Center team questions safety, efficacy of selenium and colorectal cancer risk
Selenium has been a popular nutritional supplement for decades, touted for its antioxidant properties and its role in stopping free radicals from damaging cells and DNA.
Researchers discover how selenium is incorporated into proteins
Researchers at the University of Illinois at Chicago have discovered exactly how selenium is incorporated into selenoproteins.
Selenium status influence cancer risk
As a nutritional trace element, selenium forms an essential part of our diet.
ORNL optimizes formula for cadmium-tellurium solar cells
Solar cells could move closer to theoretical levels of efficiency because of findings by researchers at Oak Ridge National Laboratory.
Mechanical engineering team gets $200K to study increasing capacity of lithium batteries
The National Science Foundation has awarded $200,022 to a research team led by Likun Zhu, an associate professor of mechanical engineering with the School of Engineering and Technology at Indiana University-Purdue University Indianapolis, to overcome problems with one approach to increasing the capacity of lithium ion batteries.
Queen's researcher leads study on using selenium to aid recovery from cardiac surgery
SodiUm SeleniTe Administration IN Cardiac Surgery (SUSTAIN) study will test the effect of high-dose selenium on patient recovery, occurrence of post-surgical complications.

Related Selenium Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#513 Dinosaur Tails
This week: dinosaurs! We're discussing dinosaur tails, bipedalism, paleontology public outreach, dinosaur MOOCs, and other neat dinosaur related things with Dr. Scott Persons from the University of Alberta, who is also the author of the book "Dinosaurs of the Alberta Badlands".