Bipolar disorder -- an understudied condition

March 15, 2007

Despite a prevalence of about 5% in the community and 50% in depressed outpatients, the treatment of bipolar II disorder* and related disorders is understudied. Recent advances in this area, which have mainly been related to these conditions, are discussed in a Seminar in this week's issue of The Lancet. Franco Benazzi (Hecker Psychiatry Research Center, Forli, Italy) reviews the concepts, definitions, and classifications of bipolar and related disorders, with a focus on bipolar II disorder and mixed depression. He notes that the apparent increase in prevalence of bipolar spectrum might be related to several changes in diagnostic criteria, including improved probing for history of hypomania, lower minimum duration of hypomania, and inclusion of unipolar depressions with bipolar signs such as family history of bipolar disorder and mixed depression. He recommends caution in the treatment of mixed depression, for which some symptoms can be worsened by antidepressants and might be better controlled by initial treatment with mood stabilisers, although further evidence is needed.

Franco Benazzi concludes: "Bipolar disorders, especially bipolar II and the related bipolar spectrum disorders, are much more common than previously reported, and treatment...is much understudied. Controlled pharmacological studies are greatly needed, and should stratify samples taking into account the frequently mixed profile of bipolar disorders".
-end-
EMBARGO: 00:01H (UK time) Friday March 16, 2007.

Notes to Editors
*Bipolar II Disorder-- is characterized by one or more major depressive episodes accompanied by at least one hypomanic episode. The key difference between Bipolar I and Bipolar II is that Bipolar II has hypomanic but not manic episodes.

Dr Franco Benazzi, Hecker Psychiatry Research Center, Flori, Italy. T) +39 335 6191 852 francobenazzi@fbenazzi.it

Lancet

Related Bipolar Disorder Articles from Brightsurf:

Amygdala changes in male patients with schizophrenia and bipolar disorder
Researchers in Japan have revealed that DNA methylation occurs in the serotonin transporter gene that regulates neurotransmitter transmission in schizophrenia and bipolar patients.

Effect of high-deductible insurance use in bipolar disorder
A new study led by the Department of Population Medicine finds that individuals with bipolar disorder who switched to high-deductible health plans (HDHPs) experienced a moderate decrease in nonpsychiatrist mental health outpatient visits, but rates of psychiatrist visits, medication use, emergency department visits, and hospitalizations did not change.

Is bipolar disorder associated with increased risk of Parkinson's disease?
This study, called a systematic review and meta-analysis, combined the results of seven studies with 4.3 million participants to examine a potential association between bipolar disorder with a later diagnosis of Parkinson's disease of unknown cause.

Bipolar disorder may be linked to Parkinson's disease
People who have bipolar disorder may be more likely to later develop Parkinson's disease than people who do not have bipolar disorder, according at a study published in the May 22, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Probiotics could help millions of patients suffering from bipolar disorder
About 3 million people in the US are diagnosed every year with bipolar disorder, a psychiatric condition characterized by dramatic shifts in mood from depression to mania.

Novel intervention for anxiety symptoms among people with Bipolar Disorder
Psychologists at Lancaster University have devised a novel psychological intervention to address Anxiety in Bipolar Disorder (AIBD).

Mutation links bipolar disorder to mitochondrial disease
Mutations in the gene ANT1 may confer a risk for bipolar disorder through a complex interplay between serotonin and mitochondrial signaling in the brain.

A new path into bipolar disorder comes to light
A new article authored by an international group of researchers reveals a novel potential drug target for bipolar disorder and offers new insights into the underlying biology of this lifelong and devastating mental illness.

After searching 12 years for bipolar disorder's cause, U-M team concludes it has many
Nearly 6 million Americans have bipolar disorder, and most have probably wondered why.

Simple EKG can determine whether patient has depression or bipolar disorder
A groundbreaking Loyola Medicine study suggests that a simple 15-minute electrocardiogram could help a physician determine whether a patient has major depression or bipolar disorder.

Read More: Bipolar Disorder News and Bipolar Disorder Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.