Nav: Home

High uric acid levels in young children may result in higher blood pressure later on

March 15, 2017

A new article published in the American Journal of Hypertension finds that very young children with increased uric acid levels had higher blood pressure at 3 years of age.

Recent studies suggest that high levels of serum uric acid of very early life are a result of the in-utero environment and may lead to elevated blood pressure in adulthood. However, serum uric acid levels can change throughout life. Researchers investigated the effect of serum uric acid levels in childhood on the blood pressure tracking and analyzed blood pressure according to changes in serum uric acid levels in early life.

Uric acid is a chemical produced when the body breaks down foods that contain organic compounds called purines. Foods and beverages with high purine contents include liver, anchovies, mackerel, dried beans, beer, and wine. High levels of uric acid have the potential to lead to gout, diabetes, and chronic kidney disease.

The prevalence of pediatric hypertension is increasing, and high blood pressure in children and adolescents is an increasingly important health problem. Recent longitudinal studies have reported the tracking of blood pressure from infancy to adolescence. High blood pressure in childhood can lead to hypertension in adulthood.

Over the past few years, increasing evidence has supported a role for uric acid in pediatric hypertension. Uric acid might play a role in the intrauterine environment, leading to increased blood pressure in later life. Preterm birth and low placental weight are significantly associated with increased serum uric acid concentration.

Researchers here measured the uric acid levels of 449 children in Seoul, South Korea, and performed at least two follow-up examinations between 2001 and 2006. The cohort was composed of mothers who visited hospitals for prenatal care between 24 and 28 weeks of gestation. The first follow-up examination was carried out when their children were 3 years of age from November 2005 to July 2010.

Data was collected across three check-up cycles. Serum uric acid levels, blood pressure, and anthropometric characteristics were assessed at 3, 5, and 7 years of age.

Baseline serum uric acid levels measured at 3 years of age, significantly affected subsequent blood pressure in the sex and body mass index adjusted longitudinal data analysis. Considering the changing pattern of serum uric acid over time, subjects with high uric acid levels at both 3 and 5 years of age had the highest systolic blood pressure at 7 years of age.

Exposure to risk factors that threaten someone's health begins during the prenatal period. However, the level of exposure can be modified while living. Therefore, although children are born with adverse birth conditions (such as preterm or low birth weight), appropriate management to control high blood pressure during childhood may help in later life.

These findings suggest the importance of maintaining appropriate levels of serum uric acids from the early life. Appropriate monitoring and intervention of uric acid levels in a high-risk group can potentially reduce the risk of a future increased blood pressure.

"Many studies have shown that early-life health can affect adulthood," said the study's lead author, Hyesook Park. "We think that along with childhood health monitoring, early intervention in childhood is the most effective way to prevent future disease."
-end-
Contact Information:

Hyesook Park, MD, Ph.D.
Department of Preventive Medicine
Ewha Womans University, Seoul, South Korea
1071 Anyangcheon-ro, Yangcheon-Ku, Seoul 158-710
hpark@ewha.ac.kr

The Article, "Association between Serum Levels of Uric Acid and Blood Pressure Tracking in Childhood" is available at https://academic.oup.com/ajh/article-lookup/doi/10.1093/ajh/hpx037

To request a copy of the study, please contact: Daniel Luzer- daniel.luzer@oup.com or 212-743-6113

Sharing on social media? Find Oxford Journals online at @OxfordJournals

Oxford University Press USA

Related Blood Pressure Articles:

Arm cuff blood pressure measurements may fall short for predicting heart disease risk in some people with resistant high blood pressure
A measurement of central blood pressure in people with difficult-to-treat high blood pressure could help reduce risk of heart disease better than traditional arm cuff readings for some patients, according to preliminary research presented at the American Heart Association's Hypertension 2019 Scientific Sessions.
Heating pads may lower blood pressure in people with high blood pressure when lying down
In people with supine hypertension due to autonomic failure, a condition that increases blood pressure when lying down, overnight heat therapy significantly decreased systolic blood pressure compared to a placebo.
The Lancet Neurology: High blood pressure and rising blood pressure between ages 36-53 are associated with smaller brain volume and white matter lesions in later years
A study of the world's oldest, continuously-studied birth cohort tracked blood pressure from early adulthood through to late life and explored its influence on brain pathologies detected using brain scanning in their early 70s.
Blood pressure control is beneficial, is it not?
Until recently, physicians had generally assumed that older adults benefit from keeping their blood pressure below 140/90 mmHg.
The 'blue' in blueberries can help lower blood pressure
A new study published in the Journal of Gerontology Series A has found that eating 200g of blueberries every day for a month can lead to an improvement in blood vessel function and a decrease in systolic blood pressure in healthy people.
More Blood Pressure News and Blood Pressure Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...