App detects harsh side effect of breast cancer treatment

March 16, 2020

Some 20 percent of breast cancer survivors will suffer from lymphedema, a potentially severe side effect of treatment that makes arms swell with lymph. The disease is often overlooked, but commercially available app-based technology now makes early detection easier, allowing for proactive treatment.

The lymphedema monitoring technology originated through research at the Georgia Institute of Technology and was further developed for market by the company LymphaTech, which also emerged from Georgia Tech. Now, a new study has benchmarked the technology, finding that it effectively detects early arm swelling associated with lymphedema in breast cancer patients.

The detection technology is intended to improve not only patients' physical health but also their peace of mind and finances.

Severe depression

"The most immediate awful consequence of lymphedema is seen in mental health. Severe depression is very high," said Brandon Dixon, who co-led the study and is an associate professor in Georgia Tech's George W. Woodruff School of Mechanical Engineering. "If you detect it early, managing it could cost as little as $2,500 in a patient's lifetime. If you catch it too late, the costs can rise as high as $200,000."

"Lymphedema is under-researched, so we don't know directly how it may lead to deadly health conditions, but there are more cases than AIDS, Parkinson's disease, and Alzheimer's disease combined, and it diminishes patients' health," Dixon said.

The researchers published the detector's test results in the journal Physical Therapy on February 10, 2019. Dixon and Georgia Tech graduates founded LymphaTech through the initiative TI:GER, Technology Innovation: Generating Economic Results at Georgia Tech's Scheller College of Business. The startup received early funding from the Georgia Research Alliance.

No cure

Lymphedema can strike breast cancer survivors if surgery includes the removal of a lymph node, slowing the flow of lymph. The liquid waste can congest the arm, at first subtly but later so drastically that patients may no longer fit into their clothing.

"It makes the stigma of cancer stick out," Dixon said. "And it is a very underappreciated disorder in medical treatment, so patients can feel stuck with it with no way out."

A German device called a perometer accurately detects arm swelling caused by lymphedema, but perometers are seldom available in the U.S. The research team could find only one in metropolitan Atlanta to benchmark the LymphaTech system against. It was located at TurningPoint Breast Cancer Rehabilitation, a non-profit center that co-led the new study in collaboration with Dixon.

The advantages of the new technology over perometers are cost and convenience. Perimeters are bulky, costly machines, while the LymphaTech system runs on iPhone or iPad and requires only a $400 camera attachment and a paid smartphone app. Both devices simply determine total volume of the arm for swelling diagnosis.

The new system performed comparably in its accuracy to the perometer in the study.

Awareness barriers

Developing LymphaTech has faced a more challenging component - spreading lymphedema awareness - and a less challenging component - arriving at the technology to accomplish this.

"In the past 20 years, depth-sensor cameras have become significantly cheaper and better. Video games, self-driving cars, robotics - they have all required better depth sensors, and we took advantage of that by using a commercially available lens attachment," Dixon said.

The camera attachment creates point clouds, 3D representations of objects, in this case of human arms, which the app uses to calculate the total arm volume. Usually, only one arm is afflicted with lymphedema, allowing clinicians to compare it with the unaffected arm for easier gauging of disease severity.

As with perometers, the LymphaTech technology avoids human error that creeps in when recording arm volume with a tape measure, a current method to assess lymphedema.

"The real battle has been to convince a medical market that has not much cared about lymphedema in the past or sought solutions to care," Dixon said. "Hopefully, the high accessibility of our solution will make it easier to care."

In a separate study involving the LymphaTech system, a research team traveled to Sri Lanka to measure lymphedema in legs, Dixon said. And in Germany, the technology is catching on with medical garment manufacturers to help them custom-fit compression sleeves to treat lymphedema.
These researchers and clinicians co-authored the study: Jill Binkley and Lauren Bober from TurningPoint Breast Cancer Rehabilitation, and LymphaTech's Michael Weiler and Nathan Frank, both of whom graduated from Georgia Tech. Paul Stratford from McMaster University also co-authored the study. Disclosures: B. Dixon owns equity in LymphaTech and may benefit financially from the technology. J.B. Dixon is affiliated with LymphaTech Inc and serves as a scientific advisor. Georgia Institute of Technology has licensed to LymphaTech technology that is related to this study and that is covered by patent applications for which J.B. Dixon is an inventor. In addition, J.B. Dixon is eligible to receive royalties under the license agreement for LymphaTech.

Georgia Institute of Technology

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