Cystic Fibrosis Foundation Launches Innovative Therapeutics Development Centers

March 16, 1998

BETHESDA, Maryland, March 16, 1998: The Cystic Fibrosis Foundation has just selected seven top (CF) care centers to be part of an innovative Therapeutics Development Center network. Through this model clinical research center network, CF researchers will more quickly translate discoveries in the laboratory about CF into new therapies.

The seven CF Therapeutics Development Centers that will serve as "hubs" for clinical trials are located at: The Johns Hopkins Hospital, Baltimore; Children’s Hospital, Boston; the University of North Carolina at Chapel Hill; Children’s Hospital Medical Center, Cincinnati; Rainbow Babies & Children's Hospital, Cleveland; Children's Hospital, Denver; and Children’s Hospital and Regional Medical Center and the University of Washington in Seattle. Each will be awarded $750,000 by the CF Foundation over a five-year period.

The CF Therapeutics Development Center network was created to capitalize on the increasing wealth of information uncovered by Foundation-supported scientists about the basic defect in CF. By establishing specialized clinical centers, researchers can seize these opportunities to intervene in the disease process through promising new CF treatments. The clinical research will also build upon early phase trials already underway in CF gene therapy, protein-assist therapy, as well as studies to test anti-infective drugs.

"Progress toward our goal * to move all promising discoveries about CF from the test tube to the bedside * will be accelerated through this program," says Robert J. Beall, Ph.D., president, CEO and medical director of the Foundation. "These centers are building the infrastructure to conduct clinical research as efficiently and quickly as possible."

Specifically, the Therapeutics Development Centers will expedite the early phases of clinical trials that evaluate safety and dosing regimens for new drugs. The final phase, which assesses the drug’s effectiveness in a large population of patients, will involve the CF Foundation’s full network of 113 accredited care centers across the country.

Cystic fibrosis is a complex, fatal genetic disease that affects about 30,000 children and adults in this country. Despite the increasing lifespan for individuals with CF, now up to 31.3 years, CF remains fatal. Therefore, life-saving therapeutics must be developed.

 The mission of the Cystic Fibrosis Foundation is to assure the development of the means to cure and control cystic fibrosis and to improve the quality of life for those with the disease.
-end-


Cystic Fibrosis Foundation

Related Cystic Fibrosis Articles from Brightsurf:

Treating cystic fibrosis with mRNA therapy or CRISPR
The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation.

Cystic fibrosis: why so many respiratory complications?
Cystic fibrosis, one of the most common genetic diseases in Switzerland, causes severe respiratory and digestive disorders.

A newly discovered disease may lead to better treatment of cystic fibrosis
Cystic fibrosis is the most frequent severe inherited disorder worldwide.

New treatment kills off infection that can be deadly to cystic fibrosis patients
The findings, which are published in the journal Scientific Reports, show that scientists from Aston University, Mycobacterial Research Group, combined doses of three antibiotics -- amoxicillin and imipenem-relebactam and found it was 100% effective in killing off the infection which is usually extremely difficult to treat in patients with cystic fibrosis.

Cystic fibrosis carriers are at increased risk for cystic fibrosis-related conditions
A University of Iowa study challenges the conventional wisdom that having just one mutated copy of the cystic fibrosis (CF) gene has no effects on a person's health.

Rare mutations drive cystic fibrosis in Caribbean
Cystic Fibrosis (CF) in the Caribbean is dominated by unusual gene mutations not often observed in previously studied CF populations, according to comprehensive genome sequencing led by physician-scientists at UC San Francisco and Centro de Neumología Pediátrica in San Juan.

Cystic fibrosis carriers at increased risk of digestive symptoms
Researchers have found that carriers of the most common genetic variant that causes cystic fibrosis experience some symptoms similar to those of people with cystic fibrosis.

In cystic fibrosis, lungs feed deadly bacteria
A steady supply of its favorite food helps a deadly bacterium thrive in the lungs of people with cystic fibrosis, according to a new study by Columbia researchers.

Cibio knocks out cystic fibrosis
The fight against cystic fibrosis continues, targeting in particular some of the mutations that cause it.

Hypertonic saline may help babies with cystic fibrosis breathe better
Babies with cystic fibrosis may breathe better by inhaling hypertonic saline, according to a randomized controlled trial conducted in Germany and published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Read More: Cystic Fibrosis News and Cystic Fibrosis Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.