Solid-pseudopapillary neoplasm of the pancreas or pancreatic endocrine tumor?

March 17, 2010

Solid-pseudopapillary neoplasm (SPN) of the pancreas is relatively rare. There are some similarities between SPN and pancreatic endocrine tumor (PET), especially the non-functioning ones, in clinical and pathological manifestations. Even the results of immunohistochemistry reported in the literature showed that the expression profiles of the two tumors overlapped, which sometimes results in difficulty distinguishing the two entities. In recent years, studies have shown that the vast majority of SPN harbor a point mutation on exon 3 of β-catenin gene, which has not yet been discovered in other pancreas tumors.

A research article published on February 28, 2010 in the World Journal of Gastroenterology addresses this question. A total of 24 cases pathologically diagnosed as SPN or PET, including 10 SPN and 14 PET, were reviewed.

Their results showed SPN of the pancreas, compared with PET, is a cystic-solid or cystic tumor with a larger size mostly seen in young women, and has the morphological features of hemorrhage and necrosis on the cut surface and exclusive pseudopapillary structures on light microscopy caused by cellular dyscohesive degeneration. If necessary, immunostaining of b-catenin and E-cadherin is quite helpful to make the differential diagnosis.
-end-
Reference: Liu BA, Li ZM, Su ZS, She XL. Pathological differential diagnosis of solid-pseudopapillary neoplasm and endocrine tumors of the pancreas. World J Gastroenterol 2010; 16(8): 1025-1030

http://www.wjgnet.com/1007-9327/16/1025.asp

Correspondence to: Bao-An Liu, Professor, Department of Pathology, Xiangya Basic Medical School, Central-south University, 110# Tongzipo Road, Changsha 410013, Hunan Province, China. lba118@yahoo.com.cn

Telephone: +86-731-82651410 Fax: +86-731-82651410

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H. pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

World Journal of Gastroenterology

Related Pancreas Articles from Brightsurf:

Diabetes researchers spot dangerous T cells in the pancreas -- even in healthy people
It's long been thought that having 'autoreactive' T cells in the pancreas was a sure sign of type 1 diabetes.

Artificial pancreas effectively controls type 1 diabetes in children age 6 and up
A clinical trial at four pediatric diabetes centers in the United States has found that a new artificial pancreas system -- which automatically monitors and regulates blood glucose levels -- is safe and effective at managing blood glucose levels in children as young as age six with type 1 diabetes.

The first mouse model of human pancreas cancer subtypes
Organoids power the first mouse model of two pancreas cancer subtypes, identifying genes influencing a lethal transformation of one subtype to the other.

New approach to pain treatment in diseases of the pancreas
One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain.

Fungal invasion of pancreas creates cancer risk
Certain fungi move from the gut to the pancreas, expand their population more than a thousand-fold, and encourage pancreatic cancer growth, a new study finds.

Pancreas on a chip
'Islet-on-a-chip' offers continuous monitoring of insulin-producing cells, indicating whether they have therapeutic value and are suitable for transplant.

Human pancreas on a chip opens new possibilities for studying disease
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD.

Rare genetic change provides clues to pancreas development
Researchers have discovered a key clue into the development of the pancreas and brain by studying rare patients born without a pancreas.

Researchers reveal new molecular mechanism involved in pancreas repair
Ramón Muñoz-Chápuli and Rita Carmona, researchers of the UMA Department of Animal Biology, have identified a new molecular mechanism involved in pancreas repair.

Oral bacteria in pancreas linked to more aggressive tumours
The presence of oral bacteria in so-called cystic pancreatic tumours is associated with the severity of the tumour, a study by researchers at Karolinska Institutet in Sweden published in the journal Gut reports.

Read More: Pancreas News and Pancreas Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.