Genetic markers play role in who benefits from aspirin, NSAIDs to lower colon cancer risk

March 17, 2015

INDIANAPOLIS - An Indiana University cancer researcher and her colleagues have identified genetic markers that may help determine who benefits from regular use of aspirin and other nonsteroidal anti-inflammatory drugs for lowering one's risk of developing colorectal cancer.

Previous studies have shown that regular use of aspirin and NSAIDs lower one's risk of colorectal cancer, but their use is not recommended as a way to prevent the disease because of uncertainty about the risks and benefits. Thus, the researchers set out to examine the interrelationship between genetic markers and the use of aspirin and NSAIDs to learn who actually benefits from their use. They did so by conducting a genome-wide analysis of gene by environment interactions.

Hongmei Nan, M.D., Ph.D., research associate professor in the Department of Epidemiology at the Richard M. Fairbanks School of Public Health at IUPUI and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and her colleagues found that colorectal cancer risk differed according to genetic variation at two single nucleotide polymorphisms -- more commonly known as SNPs -- at chromosomes 12 and 15. Interestingly, for the SNP at chromosome 12, they found that aspirin and/or NSAID use was associated with a lower risk of colorectal cancer among individuals with a specific genotype, while a higher risk was found among those with other genotypes.

Their study was published March 17 in the Journal of the American Medical Association.

"These novel findings have substantial clinical significance," Dr. Nan, the lead author, said. "Our findings, if validated in additional populations, may facilitate targeted colorectal cancer prevention strategies and contribute to precision medicine."

This study is the first and largest genome-wide analysis of gene by environment interactions between SNPs and regular use of aspirin and/or NSAIDs in relation to colorectal cancer risk. In this case-control study using the Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium, the authors included 8,634 colorectal cancer cases and 8,553 non-cancerous controls.

Colorectal cancer is the second leading cause of cancer death in the United States, according to the National Cancer Institute. In 2014, it was estimated that there would be 136,830 new cases of colorectal cancer and an estimated 50,310 people would die from the disease.
-end-
Collaborators included Ulrike Peters, Ph.D., M.P.H., and Li Hsu, Ph.D., both of the Fred Hutchinson Cancer Research Center; and Andrew Chan, M.D., M.P.H., of the Massachusetts General Hospital.

This study was supported, in part, by the National Institutes of Health under grant numbers CA137088, CA059045, CA122839, CA097735, CA074783, CA074794, CA48998, CA055075, CA167552, CA137178, CA151993, CA127003, DK098311, CA074783, CA076366, and CA154337.

Indiana University

Related Colorectal Cancer Articles from Brightsurf:

Colorectal cancer treatment: the winning combinations
Chemotherapy has distressing side effects for patients and increases the risk of developing resistance to the treatment.

A new model to predict survival in colorectal cancer
This signature could be useful in clinical practice, especially for colorectal cancer diagnosis and therapy.

Roadmap to reducing colorectal cancer deaths
The American Gastroenterological Association has outlined a strategy to increase the number of people screened via tests that are more convenient, accurate and less expensive and tailored to people's individual cancer risks.

Study provides new insight on colorectal cancer growth
A new study by researchers at the University of Kentucky identifies a novel function of the enzyme spermine synthase to facilitate colorectal cancer growth.

Researchers ID target for colorectal cancer immunotherapy
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy.

Colorectal cancer partner-in-crime identified
A protein that helps colorectal cancer cells spread to other parts of the body could be an effective treatment target.

Cancer cell reversion may offer a new approach to colorectal cancer treatment
A novel approach to reverse the progression of healthy cells to malignant ones may offer a more effective way to eradicate colorectal cancer cells with far fewer side effects, according to a KAIST research team based in South Korea.

A novel pathway to target colorectal cancer
Survival rates for patients with late-stage colorectal cancer are dismal, and new therapeutic strategies are needed to improve outcomes.

Colorectal cancer rates in Canada
The incidence of colorectal cancer among younger adults increased in recent years in this analysis of data from Canadian national cancer registries that included about 688,000 new colorectal cancers diagnosed over more than 40 years.

Cancer drugs promote stem cell properties of colorectal cancer
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells.

Read More: Colorectal Cancer News and Colorectal Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.